The development of tourism routes often involves supply and demand drivers; however, the roles of both perspectives are not well understood. This study explores this approach from both perspectives using a systematic literature review. The review of these articles is associated with the scope of the development of tourism routes. Guided by the (PRISMA) method, 56 articles were retrieved for the analysis. A comprehensive review of the articles extracted six main elements – (supply perspective) – participation, route marketing, and promotion, government strategies, destination competitiveness (demand perspective), tourist motivation, tourist satisfaction, and loyalty. Several recommendations for future studies are highlighted that relate to the approach and subject of studies from other perspectives. Overall, the concept of developing a successful tourism route requires parties from both supply and demand perspectives.