This study reports on a literature review of the leguminous tree Sesbania sesban (L.) Merr is found in the N'Djamena region, the Republic of Chad. The study focused on S. sesban’s medicinal and ethnomedicinal uses, biological features, and phytochemical constituents to assist in future evaluations. A literature review was conducted using academic websites, such as Science Direct and Springer, online international plant databases, and data from national herbaria. S. sesban is a perennial shrub or tree that measures 3–4 meters in height. This species is becoming rare in Ndjamena but can be found in the rainy season, while in winter, the species occurs mainly in ponds (called in the Chadian dialect "Bouta"), and in the shores of the Chari and Logone rivers. The local inhabitants in Chad use the species as medicine, livestock feed, fuelwood, and for improving soil fertility and repelling desert encroachment. Traditional healers use its leaves to treat breast cancer and edema. S. sesban is an essential species native to the Republic of Chad that needs conservation and valorization. Viewing its importance and rarity in N’Djamena, a strategy for replanting the species in gardens, homes, and fields around Ndjamena and other regions of Chad is recommended.