The world health organization's histological classification of salivary gland tumors. A commentary on the second edition

Seifert, G.; Sobin, Leslie H.

doi:10.1002/1097-0142(19920715)70:2<379::aid-cncr2820700202>3.0.co;2-c

Cited by 315 publications

(179 citation statements)

References 72 publications

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“…These findings are similar to other publications 12 , although they are different from studies reporting the mucoepidermoid carcinoma as the most frequent malignant neoplasia 2,14 . However, in the present study, two cases represent the difference between the number of cystic adenoid carcinoma and of mucoepidermoid, which is not considered significant when compared to other series.…”

supporting

confidence: 85%

Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos

Lima¹,

Soares²,

Amorim³

et al. 2005

Rev. Bras. Otorrinolaringol.

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Aim:The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, Study design: Historic cohort. Material and method: in the state of Sergipe, during the period 1980-1999. The neoplasms were individualized by gender, age, race of the patients, anatomic localization of the lesions and histopathological diagnosis. Results: Out of 162,312 registered cases, 245 were salivary gland epithelial neoplasms and 187 (76.33%) were benign and 58 (23.67%) were malignant. Pleomorphic adenoma was the most frequent benign neoplasm (89.94%) and adenoid cystic carcinoma represented the most prevalent malignant neoplasm (22.41%). The benign neoplasms occurred mainly between the second and third decades of life and showed preference for female, while malignant neoplasms were diagnosed between the sixth and seventh decades of life and in women. Conclusion: The data demonstrated that epidemiology profile of the studied neoplasms corroborated most of the studied literature.

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supporting

confidence: 85%

Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos

Lima¹,

Soares²,

Amorim³

et al. 2005

Rev. Bras. Otorrinolaringol.

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“…Adjusted for each other, the ln (hazard ratios) are 0.73 (Ϯ 0.15) for PS2, 0.93 (Ϯ 0.35) for spill, and 1.01 (Ϯ 0.49) for clinical grade of malignancy according to the 1991 WHO classification. 9,10 Testing the proportional hazards assumption, no indication for a changing prognostic value of PS1 in time was found. We found no evidence of nonlinearity of the relation between PS1 and ln (hazard) (P ϭ 0.36).…”

Section: Consideration Of Other Variablesmentioning

confidence: 96%

“…We are not inclined to include in the model the variables tumor spill and clinical grade of malignancy according to the 1991 WHO classification. 9 We believe that the multiple comparisons phenomenon may well be responsible for the apparent significance of these variables. The multiple comparisons-corrected P values accompanying their addition were only 0.073 (9 ϫ 0.0081) and 0.387 (9 ϫ 0.043).…”

Section: Statistical Validationmentioning

confidence: 99%

Prognostic index for patients with parotid carcinoma

Poorten

Hart

Laan

et al. 2003

Cancer

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BACKGROUNDValidation of the prognostic indices for the recurrence‐free interval of patients with parotid carcinoma, the development of which was described in a previous report, is needed to be confident of their generalizability and justified prospective use.METHODSThe Dutch Cooperative Group on Head and Neck Cancer database contains 231 patients with parotid carcinoma from six tertiary referral centers who were seen between 1985–1994. This database was used to validate the predictive value of the prognostic indices, PS1 (pretreatment index predicting recurrence) and PS2 (posttreatment index predicting recurrence), in patients with parotid carcinoma. Validation methods included calculation of both indices for each patient, comparison of coefficients, construction of survival curves using the published cutoff points, and calculation of concordance measure C. Wald tests for optimization of scale and weights of the contributing variables, and for possible score improvement by including other variables, were also performed.RESULTSThe 5‐year disease‐free rate was 62% (standard error = 4%). PS1 was calculated for 183 patients. The previously set cutoff points resulted in 5‐year disease‐free rates that ranged from 92% (PS1 = 1) to 42% for the least favorable group (PS1 = 4). Concordance measure C was 0.74. The postoperative score, PS2, was calculated for 171 patients. Previous cutoff points resulted in 5‐year disease‐free rates that ranged from 90% (PS2 = 1) to 40% (PS2 = 4). Concordance measure C was 0.71. Both PS1 and PS2 did not improve using the findings in this independent material.CONCLUSIONSThe prognostic indices performed adequately in this validation sample. This finding demonstrates that the prognosis of a parotid carcinoma patient can be quantified by using a weighted combination of the parameters of age, pain, clinical T (cT) classification, clinical N (cN) classification, skin invasion, facial nerve dysfunction, perineural growth, and involved surgical margins. A quantified prognosis, in terms of the recurrence‐free interval, can be used to provide information to the patient, to perform clinical trials, and eventually to make clinical decisions. A user‐friendly translation and computerized calculation of the indices should be the next step toward generalized prospective use and repetitive evaluation of the indices. Cancer 2003;97:1453–63. © 2003 American Cancer Society.DOI 10.1002/cncr.11254

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“…[1][2][3] Local and distant metastases are common features of this entity, regardless of the histological features or the status of surgical margins. 4,5 Alterations of cell adhesion molecules or production of excessive matrix protein have been proposed as factors associated with the aggressive behavior in adenoid cystic carcinoma. 6,7 However, the underlying events for the aggressive nature and protracted course of this tumor are poorly understood.…”

mentioning

confidence: 99%

Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma

et al. 2004

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Adenoid cystic carcinoma, a relatively uncommon tumor of salivary glands, is characterized by a prolonged clinical course and a fatal outcome. The molecular events underlying their progression are unknown. In this study, we examined the methylation status of E-cadherin gene and its protein expression in 23 cases of adenoid cystic carcinoma and correlated the results with the clinicopathologic factors to determine its role in these tumors. We also analyzed the effect of 5-azacytidine on the re-expression in a methylated cell line of adenoid cystic carcinoma for this gene. In our study, E-cadherin immunoreactivity, although heterogeneous, showed a progressive reduction with high histological grade and in metastatic and recurrent lesions. Promoter methylation was detected in 16 of 23 cases (70%), but there was no correlation with the histological grade or patient prognosis. Microdissection of immuno-negative cells in heterogeneous tumors showed positive methlyation. In the cell line from salivary adenoid cystic carcinoma with methylated E-cadherin, 5-azacytidine restored the E-cadherin expression. Our results indicate that: (1) E-cadherin gene promoter is frequently methylated in adenoid cystic carcinoma, leading to reduced E-cadherin expression, (2) variable E-cadherin expression might result from the intratumoral heterogeneity, and (3) increased extent of methylated areas may be associated with progression and advancement of the disease.

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The world health organization's histological classification of salivary gland tumors. A commentary on the second edition

Cited by 315 publications

References 72 publications

Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos

Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos

Prognostic index for patients with parotid carcinoma

Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma

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