The world of molecular cytopathology: Predictive testing and precision medicine: Highlights from the eighth International Molecular Cytopathology Meeting in Naples, Italy

Roy‐Chowdhuri, Sinchita; Rossi, Esther Diana

doi:10.1002/cncy.22317

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(2 citation statements)

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“…The high specificity of the present series supports the wide use of FNA upon suspicion of metastases, which might reduce the need for more invasive procedures (such as core biopsies) in cancer patients. In addition, cytological material is also ideal for molecular studies, for specific phenotyping and targeted therapy, and there have been several reports on the usefulness and superior quality of cytology for these assays 27,28 . This is of pivotal importance in cancer patients, especially those with advanced disease, for whom more invasive procedures might be clinically challenging.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, cytological material is also ideal for molecular studies, for specific phenotyping and targeted therapy, and there have been several reports on the usefulness and superior quality of cytology for these assays. 27,28 This is of pivotal importance in cancer patients, especially those with advanced disease, for whom more invasive procedures might be clinically challenging.…”

Section: This Is Probably Due To the Use Of Rose For All Cases Which ...mentioning

confidence: 99%

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Accuracy of fine‐needle aspiration of lymph nodes: A cancer center’s experience

et al. 2021

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Introduction Lymph node fine needle aspiration (LN‐FNA) is a minimally invasive method of evaluating lymphadenopathy. Nonetheless, its use is not widely accepted due to the lack of guidelines and a cytopathological categorisation that directly relates to management. We report our experience with LN FNA at a large Cancer Center in Latin America. Methods We retrospectively collected cytological cases of lymph node FNA from the department of pathology at AC Camargo Cancer Center performed over a 2‐year period. Data extracted included LN location, age, sex and final cytological diagnosis. Patients that had undergone neoadjuvant chemotherapy and/or cases for which the surgery specimen location was not clearly reported were excluded. For those cases with surgical reports, risk of malignancy was calculated for each diagnostic category, along with overall performance of cytology. False positive cases were reviewed to assess any possible misinterpretation or sampling errors. Results A total of 1730 LN‐FNA were distributed as follows: 62 (3.5%) non‐diagnostic (ND); 1123 (64.9%) negative (NEG), 19 (1.1%) atypical (ATY), 53 (3.1%) suspicious for malignancy (SUS), and 473 (27.3%) positive (POS). Surgical reports were available for 560 cases (32.4%). Risk of malignancy (ROM) for each category was 33.3% for ND, 29.9% for NEG, 25% for ATY, 74.2% for SUS and 99.6% for POS. Overall sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) were 78.5%, 99.4%, 70.2% and 99.6%, respectively. Conclusion Lymph node FNA is a very specific and accurate exam, which is reliable in the detection of lymph node metastasis and other causes of lymphadenopathy.

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Section: Discussionmentioning

confidence: 99%

Section: This Is Probably Due To the Use Of Rose For All Cases Which ...mentioning

confidence: 99%