The Wound-Healing Effect of Fibrin Glue for Tracheal Anastomosis in Experimental Pulmonary Surgery

Takagi, Masamichi; Akiba, Tadashi; Yamazaki, Yoji; Nariai, Koichi; Iwaki, Takamasa

doi:10.1007/s005950170063

Cited by 13 publications

(8 citation statements)

References 3 publications

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“…The use of fibrin sealants for topical hemostasis and tissue sealing is a traditional paradigm, wherein the sealant accelerates the healing of injured or grafted tissues and improves wound closure in conjunction with sutures treatments, as established in maxillofacial and periodontal surgery [57,105,106]. The beneficial effect of fibrin sealants has been well documented in a wide array of surgical applications, similar to the treatments where PRP has been used, such as colon surgery [107,108], biliary tract [109], hernia repair [110], urologic surgery [111], and thoracic surgery [112], among others. However, studies of the direct effect of fibrin sealants on bone repair and the effectiveness of sealants in augmenting bone graft healing have produced conflicting results (reviewed in [95]).…”

Section: Applications Of Fibrin Sealantsmentioning

confidence: 99%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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Section: Applications Of Fibrin Sealantsmentioning

confidence: 99%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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“…The reconstruction techniques applied for tracheal anastomoses after tracheal resection are similar to each other, but different tissues and materials are used to re-inforce the anastomoses. For example, strep muscles, fibrin glue, bovine pericardium, Polytetrafluoroethylene (PTFE), and PGA+fibrin glue are some of the materials and tissues used [9,21].…”

Section: Discussionmentioning

confidence: 99%

The effect of polyglycolic acid mesh application in tracheal anastomoses on pressure and tensile strength: an ex vivo experimental study

Kılıçgün¹,

Biçer²,

Kutluk³

et al. 2019

Curr Thorac Surg

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To cite this article: Kılıçgün A, Biçer YO, Kutluk AC, Seyhan S, Köybaşı Sanal S. The effect of polyglycolic acid mesh application in tracheal anastomoses on pressure and tensile strength: an ex vivo experimental study. Curr ABSTRACTBackground: This study aims to investigate the effect of polyglycolic acid (PGA) mesh application in tracheal anastomosis on the air-leakage and tension resistance. Materials and Methods:Tracheae were collected from freshly slaughtered healthy sheep weighing 25-30 kg (2-3 years old) that were acquired from the local slaughterhouse. Twenty-eight tracheae were transported to the laboratory within an hour of slaughter and then dissected to remove the esophagus before obtaining 20-cm long tracheae. All tracheae were transected at the midpoint. In Groups 1 and 2, the transected tracheae were anastomosed by using interrupted 3-0 Vicryl sutures. In Groups 3 and 4, after anastomosing the transected tracheae with interrupted 3-0 Vicryl, the sites of anastomosis were reinforced by using Polyglycolic acid mesh. Groups 1 and 3 were tested for tensile strength, while Groups 2 and 4 were tested for pressure resistance. Results:The median pressure was 49.00 ± 7.47 mmHg in the group anastomosed with only Vicryl, whereas it was measured as 70 ± 13.49 mmHg in the group on which the anastomoses were reinforced with PGA mesh. The median force needed to break anastomoses were 166.40 ± 24.28 Newton in the Vicryl-only group and 136.80 ± 34.93 newton in the PGA-reinforced group. The difference between the pressure resistance values of the Vicryl-only group and the PGA reinforced group was significant (p = 0.006). However, the difference with regard to the tensile strength was insignificant (p = 0.201). Conclusion:We found that the reinforcement of the anastomosis site with polyglycolic acid mesh significantly increases the pressure resistance but does not significantly affect tensile strength.

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“…Так, M. Takagi, А. Каскer и соавт. [29,30] провели эксперимент на крысах, которым проводили трахеотомию на 2 / 3 окружности с последующим ушиванием отдельными узловыми швами из рассасывающегося материала. После формирования анастомоза на линию швов наносили 0,5 мл фибринного клея.…”

Section: The Possibilities For the Prevention Of Incompetent Tracheorunclassified

The possibilities for the prevention of incompetent tracheorrhaphy

Иноземцев

Kurgansky

Лепехова

et al. 2018

Vestn. otorinolaringol.

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The present review of the literature is focused on the methods designed for the prevention of incompetent tracheorrhaphy. The main cause that dictates the necessity of strengthening the sutures is the risk of the development of the complications during the postoperative period following the surgical interventions. The incompetence of the tracheal anastomoses is known to occur in 3.6-26.3% of the patients which leads to the development of such complications as neck phlegmon, mediastinitis, and pleural empyema. The mortality rate amounts to 18.2%. The authors describe the methods employed for the prevention of incompetent tracheorrhaphy following the circular resections and suturing of the linear traumatic defects. The advantages and disadvantages of individual methods are discussed.

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The Wound-Healing Effect of Fibrin Glue for Tracheal Anastomosis in Experimental Pulmonary Surgery

Cited by 13 publications

References 3 publications

A review on endogenous regenerative technology in periodontal regenerative medicine

A review on endogenous regenerative technology in periodontal regenerative medicine

The effect of polyglycolic acid mesh application in tracheal anastomoses on pressure and tensile strength: an ex vivo experimental study

The possibilities for the prevention of incompetent tracheorrhaphy

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