The yin and yang of viruses and interferons

Wang, Ben X.; Fish, Eleanor N.

doi:10.1016/j.it.2012.01.004

Cited by 103 publications

(94 citation statements)

References 86 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ribavirin, in combination with pegylated IFN-α, is the main treatment against Hepatitis C virus. However, IFN-α/β and ribavirin treatments are of relatively poor efficacy in vivo against most RNA viruses as they efficiently blunt IFN-α/β signaling through expression of virulence factors 5 and often escape ribavirin 3 . This added to the fact that ribavirin treatment is raising important toxicity issues, although it was recently approved against severe hRSV disease with controversial benefits 6 .…”

Section: Introductionmentioning

confidence: 99%

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Lucas‐Hourani

Munier‐Lehmann

Helynck

et al. 2014

JoVE

View full text Add to dashboard Cite

RNA viruses are responsible for major human diseases such as flu, bronchitis, dengue, Hepatitis C or measles. They also represent an emerging threat because of increased worldwide exchanges and human populations penetrating more and more natural ecosystems. A good example of such an emerging situation is chikungunya virus epidemics of [2005][2006] in the Indian Ocean. Recent progresses in our understanding of cellular pathways controlling viral replication suggest that compounds targeting host cell functions, rather than the virus itself, could inhibit a large panel of RNA viruses. Some broad-spectrum antiviral compounds have been identified with host target-oriented assays. However, measuring the inhibition of viral replication in cell cultures using reduction of cytopathic effects as a readout still represents a paramount screening strategy. Such functional screens have been greatly improved by the development of recombinant viruses expressing reporter enzymes capable of bioluminescence such as luciferase. In the present report, we detail a high-throughput screening pipeline, which combines recombinant measles and chikungunya viruses with cellular viability assays, to identify compounds with a broad-spectrum antiviral profile. Video LinkThe video component of this article can be found at

show abstract

Section: Introductionmentioning

confidence: 99%

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Lucas‐Hourani

Munier‐Lehmann

Helynck

et al. 2014

JoVE

View full text Add to dashboard Cite

show abstract

“…THs are able to enhance sensitivity of lymphocytes to interferons (IFN) and promote IFN-mediated cytotoxic activity of NK cells (Provinciali & Fabris, 1990;Provinciali et al, 1994). Interferons (i.e., , , and g) are small regulatory cytokines that were originally identified as anti-viral factors and play pivotal roles in immune responses to viral infection (Wang & Fish, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Data from recent studies have revealed that these hormones may also control the latency/reactivation and infectivity of viruses (HSV-1 in particular) via regulation of gene expression (Davis et al, 2011;Wang & Fish, 2012). Host immune responses to HSV-1 infection, like those to other viral infections, are complex.…”

Section: Introductionmentioning

confidence: 99%

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Varedi¹,

Shiri²,

Moattari³

et al. 2013

Journal of Immunotoxicology

View full text Add to dashboard Cite

Increasingly in recent years, thyroid hormones (THs) have been considered to be important regulators of the immune system. However, their roles in host defense against viral infections are not clearly established. Therefore, this study was undertaken to examine proliferative activity and cytokine production by lymphocytes isolated from hyperthyroid and euthyroid Balb/c mice in response to herpes simplex virus-1 (HSV-1). Lymphocytes of hyperthyroid animals showed a significantly higher rate of proliferation and interferon (IFN)-g production when compared with that by lymphocytes from euthyroid mice. In vitro thyroxine (T4) treatment was similarly effective in the potentiation of proliferation, but not IFNg production, by euthyroid lymphocytes. Furthermore, the hyperthyroid state significantly attenuated ConA-, but not HSV-1-, induced interleukin (IL)-10 release; in vitro T4 treatment synergized this effect. These findings suggest that supra-physiologic TH levels (i.e. as occur in hyper-thyroid states) or in vitro TH treatment modulate T-helper (T H )1/T H 2 lymphocyte responses and thereby amplifies host defenses against viral infections. One may also conclude that THs may have a potential application in viral immunization and/or treatment of viral infections.

show abstract

“…Optimal productions of type I IFNs are crucial for maintaining immune homeostasis and elimination of invading viruses (18,19). Thus, type I IFN secretion must be tightly controlled.…”

Section: Discussionmentioning

confidence: 99%

Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses

Huai

Song

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Type I IFNs (IFN-α/β) play crucial roles in the elimination of invading viruses. Multiple immune cells including macrophages recognize viral infection through a variety of pattern recognition receptors, such as Toll-like receptors (TLRs) and retinoic acid-inducible gene-I (RIG-I)-like receptors, and initiate type I IFN secretion and subsequent antiviral immune responses. However, the mechanisms by which host immune cells can produce adequate amounts of type I IFNs and then eliminate viruses effectively remain to be further elucidated. In the present study, we show that munc18-1-interacting protein 3 (Mint3) expression can be markedly induced during viral infection in macrophages. Mint3 enhances TLR3/4-and RIG-I-induced IRF3 activation and IFN-β production by promoting K63-linked polyubiquitination of TNF receptor-associated factor 3 (TRAF3). Consistently, Mint3 deficiency greatly attenuated antiviral immune responses and increased viral replication. Therefore, we have identified Mint3 as a physiological positive regulator of TLR3/4 and RIG-I-induced IFN-β production and have outlined a feedback mechanism for the control of antiviral immune responses.interferon | viral infection | TLR | RIG-I | TRAF3

show abstract

The yin and yang of viruses and interferons

Cited by 103 publications

References 86 publications

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens

Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses

Contact Info

Product

Resources

About

The yin and yang of viruses and interferons

Cited by 103 publications

References 86 publications

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Hyperthyroid state orin vitrothyroxine treatment modulates TH1/TH2 responses during exposure to HSV-1 antigens

Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses

Contact Info

Product

Resources

About

Hyperthyroid state orin vitrothyroxine treatment modulates T_H1/T_H2 responses during exposure to HSV-1 antigens