The Yin-Yang Regulation of Reactive Oxygen Species and MicroRNAs in Cancer

Babu, Kamesh R.; Tay, Yvonne

doi:10.3390/ijms20215335

Cited by 51 publications

(29 citation statements)

References 140 publications

(162 reference statements)

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“…Several studies showed that T 3 –THRs–TREs signaling affects miRNAs expression ( Dong et al, 2010 ; Janssen et al, 2014 ; Babu and Tay, 2019 ). For instance, T 3 –THRs–TREs binds to miR-17 promoter and decreases transcription and processing of mature miR-17, involved in cancer ( Lin Y. H. et al, 2013b ).…”

Section: Interplay Between Ths Wnt Pathway and Mirnas During Inflammentioning

confidence: 99%

Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome

Luca

Davis

Lin

et al. 2021

Front. Cell Dev. Biol.

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The interdependence between thyroid hormones (THs), namely, thyroxine and triiodothyronine, and immune system is nowadays well-recognized, although not yet fully explored. Synthesis, conversion to a bioactive form, and release of THs in the circulation are events tightly supervised by the hypothalamic–pituitary–thyroid (HPT) axis. Newly synthesized THs induce leukocyte proliferation, migration, release of cytokines, and antibody production, triggering an immune response against either sterile or microbial insults. However, chronic patho-physiological alterations of the immune system, such as infection and inflammation, affect HPT axis and, as a direct consequence, THs mechanism of action. Herein, we revise the bidirectional crosstalk between THs and immune cells, required for the proper immune system feedback response among diverse circumstances. Available circulating THs do traffic in two distinct ways depending on the metabolic condition. Mechanistically, internalized THs form a stable complex with their specific receptors, which, upon direct or indirect binding to DNA, triggers a genomic response by activating transcriptional factors, such as those belonging to the Wnt/β-catenin pathway. Alternatively, THs engage integrin αvβ3 receptor on cell membrane and trigger a non-genomic response, which can also signal to the nucleus. In addition, we highlight THs-dependent inflammasome complex modulation and describe new crucial pathways involved in microRNA regulation by THs, in physiological and patho-physiological conditions, which modify the HPT axis and THs performances. Finally, we focus on the non-thyroidal illness syndrome in which the HPT axis is altered and, in turn, affects circulating levels of active THs as reported in viral infections, particularly in immunocompromised patients infected with human immunodeficiency virus.

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Section: Interplay Between Ths Wnt Pathway and Mirnas During Inflammentioning

confidence: 99%

Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome

Luca

Davis

Lin

et al. 2021

Front. Cell Dev. Biol.

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“…Homogenous KRAS G12D mutant, a common mutation causing dysregulation of the MAPK pathway, has been reported to favor glucose fueled TCA cycling due to glucose metabolic reprogramming and reactive oxygen species (ROS) management, leading to increased malignancy [255]. The interplay between miRNA and ROS in cancer treatment response has been discussed in recent reviews [256,257]. Non-coding RNAs such as miR-21 and miR-30c have shown upregulation with KRAS G12D overexpression, which as a result enhance regulation of Ras downstream pathways [207].…”

Section: Ras/raf/mek/erk (Mapk)mentioning

confidence: 99%

Non-Coding RNAs in Lung Tumor Initiation and Progression

Santos

Moreno

Zhang

2020

IJMS

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Lung cancer is one of the deadliest forms of cancer affecting society today. Non-coding RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), through the transcriptional, post-transcriptional, and epigenetic changes they impose, have been found to be dysregulated to affect lung cancer tumorigenesis and metastasis. This review will briefly summarize hallmarks involved in lung cancer initiation and progression. For initiation, these hallmarks include tumor initiating cells, immortalization, activation of oncogenes and inactivation of tumor suppressors. Hallmarks involved in lung cancer progression include metastasis and drug tolerance and resistance. The targeting of these hallmarks with non-coding RNAs can affect vital metabolic and cell signaling pathways, which as a result can potentially have a role in cancerous and pathological processes. By further understanding non-coding RNAs, researchers can work towards diagnoses and treatments to improve early detection and clinical response.

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“…Moreover, it is interesting to note that different subtypes of BC have different levels of ROS production among which TNBC shows the highest level of ROS [136]. A recent review by Babu and Tay on ROS signaling in cancer progression mentions an excisting crosstalk between ROS and miRNA regulation [137]. ROS can affect the miRNA expression by different mechanisms, such as epigenetic modulation of miRNA or by modifying the expression of transcription factors involved in the miRNA biogenesis.…”

Section: Ros Sensing Mirnas and Tumor Angiogenesismentioning

confidence: 99%

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

et al. 2020

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Several phytochemicals have been identified for their role in modifying miRNA regulating tumor progression. miRNAs modulate the expression of several oncogenes and tumor suppressor genes including the genes that regulate tumor angiogenesis. Hypoxia inducible factor-1 alpha (HIF-1α) signaling is a central axis that activates oncogenic signaling and acts as a metabolic switch in endothelial cell (EC) driven tumor angiogenesis. Tumor angiogenesis driven by metabolic reprogramming of EC is crucial for tumor progression and metastasis in many different cancers, including breast cancers, and has been linked to aberrant miRNA expression profiles. In the current article, we identify different miRNAs that regulate tumor angiogenesis in the context of oncogenic signaling and metabolic reprogramming in ECs and review how selected phytochemicals could modulate miRNA levels to induce an anti-angiogenic action in breast cancer. Studies involving genistein, epigallocatechin gallate (EGCG) and resveratrol demonstrate the regulation of miRNA-21, miRNA-221/222 and miRNA-27, which are prognostic markers in triple negative breast cancers (TNBCs). Modulating the metabolic pathway is a novel strategy for controlling tumor angiogenesis and tumor growth. Cardamonin, curcumin and resveratrol exhibit their anti-angiogenic property by targeting the miRNAs that regulate EC metabolism. Here we suggest that using phytochemicals to target miRNAs, which in turn suppresses tumor angiogenesis, should have the potential to inhibit tumor growth, progression, invasion and metastasis and may be developed into an effective therapeutic strategy for the treatment of many different cancers where tumor angiogenesis plays a significant role in tumor growth and progression.

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The Yin-Yang Regulation of Reactive Oxygen Species and MicroRNAs in Cancer

Cited by 51 publications

References 140 publications

Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome

Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome

Non-Coding RNAs in Lung Tumor Initiation and Progression

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

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