The timing and mechanism of the closure of the Palaeo-Asian Ocean are problematic and controversial. To help resolve these problems, we report geochronological, geochemical, and isotopic data from mid-Triassic adakitic intrusions in the Eastern Tianshan, NW China. U-Pb dating shows that the adakitic intrusions formed at 243-234 Ma. These mid-Triassic adakitic intrusions are characterized by high Sr/Y and La/Yb ratios, low Yb and Y, and positive ε Nd (t) (+3.12 − +4.71) and low ( 87 Sr/ 86 Sr) i (0.703956-0.704487) values. However, they have high K and low A/NK values (1.16-1.71), relatively low MgO (0.43-1.81 wt%) contents, and Mg # (44-61), low abundances of compatible elements (Cr = 4.09-16.69 ppm, Ni = 2.02-8.03 ppm), which are different from the typical slab-melting adakites. These features indicate that they were derived from the partial melting of the relatively depleted thickened lower crust. Our new geochronological, geochemical, and isotopic data integrated with the established amalgamation of nearby arcs lead us to conclude that the adakitic intrusions were most likely generated by partial melting of the tectonically thickened (>40 km) juvenile Dananhu intra-oceanic arc and, therefore, the Kanguer branch of the Palaeo-Asian Ocean closed since ca. 234 Ma. K E Y W O R D S accretionary orogeny, adakite, Eastern Tianshan, new crustal growth, thickened arc crustal melting Drummond, 1990) are andesitic to rhyolitic, extrusive, and intrusive rocks generated by slab melting in subduction zones. However, the compositions of some adakitic rocks are controversial, leading to alternative mechanisms of generation, for example, partial melting of the tectonically thickened mafic lower crust