Abstract. The zero-divisor graph of a noncommutative ring R, denoted by Γ(R), is a graph whose vertices are nonzero zero-divisors of R, and there is a directed edge from a vertex x to a distinct vertex y if and only if xy = 0. Let R = M 2 (Fq) be the 2 × 2 matrix ring over a finite field Fq. In this article, we investigate the automorphism group of Γ(R).