The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach

Royston, C. M. S.; Brew, D. St. J.; Garnham, J. R.; Stagg, B. H.; Polak, Julia M.

doi:10.1136/gut.13.8.638

Cited by 53 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Somewhat paradoxically, the stomach, which under physiological conditions contains most of the G cells of the organism, appears as a very rare site of origin for gastrinomas [7,14,16]. A review of the literature disclosed fewer than 20 reported gastric gastrinomas presenting as a mucosal polyp or as unique or multiple intramural nodules [9,12,13,14]. The possibility of a primary paraduodenal nodal gastrinoma, which might have been considered from the scintigraphic data, was positively ruled out by the finding of a parenchymal gastrin-producing neuroendocrine tumor and the involvement of multiple locoregional lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

et al. 2002

View full text Add to dashboard Cite

We report a unique case of a gastric collision tumor composed of an intramural gastrin-secreting tumor and a papillotubular adenocarcinoma of the intestinal type discovered at autopsy in a patient with Zollinger-Ellison syndrome. There was extensive metastatic dissemination of the neuroendocrine component to regional lymph nodes and to the liver. The unusual macroscopical, histological, and immunohistochemical features of this case and its specific clinical setting are discussed

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

et al. 2002

View full text Add to dashboard Cite

show abstract

“…It is well known that gastrin has a strong trophic effect on gastric mucosal cells, because this action has been found in patients with Zollinger-Ellison syndrome, 1 and in animals subjected to long-term gastric acid suppression, [2][3][4] in which serum gastrin levels are greatly elevated. This trophic effect was regarded as a nonspecific effect on the whole gastric mucosa, [5][6][7] but studies on rats treated with histamine H 2 receptor antagonists or proton pump inhibitors have shown that the trophic effect on enterochromaffin-like (ECL) cells was much greater than that on the other epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of a histamine H 1 receptor antagonist on gastric endocrine cell proliferation induced by chronic acid suppression in rats

Chen

Kashiwagi

Omura

et al. 2000

Journal of Gastroenterology

View full text Add to dashboard Cite

The effect of histamine on gastrin cells and enterochromaffin-like cells has not yet been clarified. We investigated the influence of pyrilamine (a histamine H1 receptor antagonist) on serum gastrin level, gastrin cells, and enterochromaffin-like cells in rats with or without 4 weeks of famotidine treatment. The rats were divided into six groups: a control group, two pyrilamine groups (2mg/kg, or 20mg/kg, p.o.), a famotidine group (20mg/kg twice/daily i.m.), and two pyrilamine + famotidine groups. The serum gastrin concentration was determined, and gastrin cells and enterochromaffin-like cells were identified by the labeled streptavidin biotin complex method and counted. Hypergastrinemia, gastrin cell hyperplasia, and enterochromaffin-like cell hyperplasia were found after 4 weeks of famotidine treatment. Four weeks of treatment with pyrilamine alone did not affect the gastrin level, gastrin cells, or enterochromaffin-like cells in the rat stomach. When combined with famotidine, pyrilamine enhanced famotidine-induced hypergastrinemia, but it did not affect gastrin cell hyperplasia, and it significantly inhibited enterochromaffin-like cell hyperplasia. These results suggest that gastrin secretion and enterochromaffin-like cell proliferation may be regulated by histamine via the H1 receptor during acid suppression.

show abstract

“…The Zollinger-Ellison syndrome has been reported in association with a gastrin-producing tumour of the stomach (Royston et al, 1972). A patient presenting with severe small and large intestinal stasis and marked villous hypertrophy of the jejunum had these symptoms reversed by removal of a renal tumour (Gleeson et al, 1971) shown to contain large amounts of enteroglucagon which would account satisfactorily for the symptoms (Bloom, 1972).…”

Section: Tumours Secreting Enterohormonesmentioning

confidence: 99%

Tests of Exocrine Pancreatic Function

Gowenlock

1977

Ann Clin Biochem

View full text Add to dashboard Cite

The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach

Cited by 53 publications

References 15 publications

Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Gastric collision between a papillotubular adenocarcinoma and a gastrinoma in a patient with Zollinger-Ellison syndrome

Effect of a histamine H 1 receptor antagonist on gastric endocrine cell proliferation induced by chronic acid suppression in rats

Tests of Exocrine Pancreatic Function

Contact Info

Product

Resources

About