Theoretical and experimental approach to hydrophilic interaction dispersive solid-phase extraction of 2-aminothiazoline-4-carboxylic acid from human post-mortem blood

Giebułtowicz, Joanna; Sobiech, Monika; Ruzycka-Ayoush, Monika; Luliński, Piotr

doi:10.1016/j.chroma.2018.12.028

Cited by 26 publications

(7 citation statements)

References 27 publications

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“…To overcome existing problems, new analytical strategies that allow lower limits of quantification, improve accuracy, enhance selectivity, and minimize matrix effects are urgently needed. Here, molecularly imprinted polymers (MIPs) could be recognized as valuable selective sorbents because of their synthetic process, which proceeds in the presence of the template molecule. − Recently, Sobiech and co-workers designed a MIP sorbent for the extraction of hordenine from human urine samples after beer consumption. However, to elaborate the analytical method available for a more complex matrix as well as to facilitate the process and make it faster, new strategies have been considered.…”

Section: Introductionmentioning

confidence: 99%

Application of Magnetic Core–Shell Imprinted Nanoconjugates for the Analysis of Hordenine in Human Plasma-Preliminary Data on Pharmacokinetic Study after Oral Administration

Sobiech

Giebułtowicz

Luliński

2020

J. Agric. Food Chem.

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In this paper, we developed and validated a new analytical method to determine the pharmacokinetic profile of hordenine in plasma samples of human volunteers after oral administration of hordenine-rich dietary supplements. For this purpose, a magnetic molecularly imprinted sorbent was fabricated and characterized. The application of a magnetic susceptible material facilitates pretreatment step while working with a highly complex sample, reducing time and costs. An optimized, fast, and reliable separation step was combined with liquid chromatography tandem mass spectrometry, providing an analytical method for analysis of hordenine in human plasma after dietary supplement intake. The method was validated (lower limit of quantification of 0.05 μg/L), enabling the pharmacokinetic profile of hordenine to be determined. The highest concentration of hordenine was noted after 65 ± 14 min, reaching the value of 16.4 ± 7.8 μg/L. The average t 1/2 was 54 ± 19 min. The apparent volume of distribution was 6000 ± 2600 L (66 ± 24 L/kg when adjusted for weight).

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Section: Introductionmentioning

confidence: 99%

Application of Magnetic Core–Shell Imprinted Nanoconjugates for the Analysis of Hordenine in Human Plasma-Preliminary Data on Pharmacokinetic Study after Oral Administration

Sobiech

Giebułtowicz

Luliński

2020

J. Agric. Food Chem.

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“…Next, the template was removed and the adsorption process of different compounds was simulated prior to the analysis. In more complicated systems, the solvent molecules were taken into account during the modelling and the analysis of the interactions [40][41][42]. Another idea of computational modelling was the formation of a polymeric chain model and studying of the analyte-chain interactions.…”

Section: Overview Of the Imprinting Processmentioning

confidence: 99%

Imprinting Technology for Effective Sorbent Fabrication: Current State-of-Art and Future Prospects

2021

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In the last 10 years, we have witnessed an extensive development of instrumental techniques in analytical methods for determination of various molecules and ions at very low concentrations. Nevertheless, the presence of interfering components of complex samples hampered the applicability of new analytical strategies. Thus, additional sample pre-treatment steps were proposed to overcome the problem. Solid sorbents were used for clean-up samples but insufficient selectivity of commercial materials limited their utility. Here, the application of molecularly imprinted polymers (MIPs) or ion-imprinted polymers (IIPs) in the separation processes have recently attracted attention due to their many advantages, such as high selectivity, robustness, and low costs of the fabrication process. Bulk or monoliths, microspheres and core-shell materials, magnetically susceptible and stir-bar imprinted materials are applicable to different modes of solid-phase extraction to determine target analytes and ions in a very complex environment such as blood, urine, soil, or food. The capability to perform a specific separation of enantiomers is a substantial advantage in clinical analysis. The ion-imprinted sorbents gained interest in trace analysis of pollutants in environmental samples. In this review, the current synthetic approaches for the preparation of MIPs and IIPs are comprehensively discussed together with a detailed characterization of respective materials. Furthermore, the use of sorbents in environmental, food, and biomedical analyses will be emphasized to point out current limits and highlight the future prospects for further development in the field.

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“…The concentrations of six α-keto acids were between 1.55 and 316 pmol per 106 cells and LODs were within 1.3 and 5.4 nM, being three-fold higher than that of OPD. Quantification entailing OPD derivatization and fluorescence detection has been reported by several groups, wherein LODs were between 18 nM and 1 µM [70][71][72]. DMB was developed to improve the sensitivity of fluorescence detection, and has a structure similar to that of OPD.…”

Section: α-Keto Acids and Their Metabolitesmentioning

confidence: 99%

“…After investigation of the surface morphology, interferences were significantly reduced. A robust SPE was developed for hydrophilic interactions, allowing for a high accuracy of 96% [71]. Furthermore, it is environmentally benign and entails a simple procedure.…”

Section: Carboxylic Acids Containing a Thiazole Ringmentioning

confidence: 99%

Liquid-Chromatographic Methods for Carboxylic Acids in Biological Samples

et al. 2020

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Carboxyl-bearing low-molecular-weight compounds such as keto acids, fatty acids, and other organic acids are involved in a myriad of metabolic pathways owing to their high polarity and solubility in biological fluids. Various disease areas such as cancer, myeloid leukemia, heart disease, liver disease, and lifestyle diseases (obesity and diabetes) were found to be related to certain metabolic pathways and changes in the concentrations of the compounds involved in those pathways. Therefore, the quantification of such compounds provides useful information pertaining to diagnosis, pathological conditions, and disease mechanisms, spurring the development of numerous analytical methods for this purpose. This review article addresses analytical methods for the quantification of carboxylic acids, which were classified into fatty acids, tricarboxylic acid cycle and glycolysis-related compounds, amino acid metabolites, perfluorinated carboxylic acids, α-keto acids and their metabolites, thiazole-containing carboxylic acids, and miscellaneous, in biological samples from 2000 to date. Methods involving liquid chromatography coupled with ultraviolet, fluorescence, mass spectrometry, and electrochemical detection were summarized.

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Theoretical and experimental approach to hydrophilic interaction dispersive solid-phase extraction of 2-aminothiazoline-4-carboxylic acid from human post-mortem blood

Cited by 26 publications

References 27 publications

Application of Magnetic Core–Shell Imprinted Nanoconjugates for the Analysis of Hordenine in Human Plasma-Preliminary Data on Pharmacokinetic Study after Oral Administration

Application of Magnetic Core–Shell Imprinted Nanoconjugates for the Analysis of Hordenine in Human Plasma-Preliminary Data on Pharmacokinetic Study after Oral Administration

Imprinting Technology for Effective Sorbent Fabrication: Current State-of-Art and Future Prospects

Liquid-Chromatographic Methods for Carboxylic Acids in Biological Samples

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