Theoretical and experimental investigations of the optical waveguiding properties of on-chip microfabricated capillaries

Grewe, M.; Grosse, Axel; Fouckhardt, Henning

doi:10.1007/pl00021143

Cited by 19 publications

(11 citation statements)

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“…However, the size of core region was limited by thin-film deposition process and may not meet the requirement for larger flow channel applications. In addition, Grewe and co-workers reported an optical leaky waveguide device in fused silica using wet chemical etching and bonding techniques [7,8]. Nevertheless, surface roughness of the etched channel [9,10] and a small refraction index difference at the core/wall interface affected the performance of the device.…”

Section: Introductionmentioning

confidence: 99%

Micro flow cytometers with buried SU-8/SOG optical waveguides

Lee

Lin

Chang

2003

Sensors and Actuators A: Physical

108

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Section: Introductionmentioning

confidence: 99%

Micro flow cytometers with buried SU-8/SOG optical waveguides

Lee

Lin

Chang

2003

Sensors and Actuators A: Physical

108

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“…For most applications, it is favorable to achieve very smooth surfaces during wet or dry glass etching (see, e.g., [27,[36][37][38][39] for fused silica). But a paradigm change is taking place, since rough optical surfaces can act as quasilayers with new optical functions.…”

Section: Dry-etching Resultsmentioning

confidence: 99%

nm- andμm-Scale Surface Roughness on Glass with Specific Optical Scattering Characteristics on Demand

Fouckhardt

Steingoetter

Brinkmann

et al. 2007

Advances in OptoElectronics

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During maskless ion etching of amorphous glass, self-organization can arise in certain etch parameter ranges, which leads to dense-lying dots/cones with typical diameters and heights in the 30-300 nm range. Another phenomenon, which results in cone sizes around 1 μm or more, is self-masking especially in the case of heterogeneous glasses like borosilicate glass as used in this contribution. Thus, a wide range of characteristic sizes and shapes of individual scatterers on the glass surface, jointly acting as a defined roughness, can be achieved resulting in specific optical scattering characteristics. This contribution gives results on borosilicate thin-glass dry etching. Certain surface morphologies are reported together with experimental results on their optical scattering characteristics.

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“…Consequently, several studies have investigated the use of microdevices with integrated optical waveguides/fibers for the optical detection of biomolecules, such as proteins and DNA. For example, Grewe et al fabricated an optical leaky waveguide device in fused silica using wet chemical etching and bonding techniques [9,10]. However, the leaky operation mode of this device could result in optical losses in the waveguide.…”

Section: Introductionmentioning

confidence: 98%

A microfabricated capillary electrophoresis chip with multiple buried optical fibers and microfocusing lens for multiwavelength detection

2005

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We present a new microfluidic device utilizing multiwavelength detection for high-throughput capillary electrophoresis (CE). In general, different fluorescent dyes are only excited by light sources with appropriate wavelengths. When excited by an appropriate light source, a fluorescent dye emits specific fluorescence signals of a longer wavelength. This study designs and fabricates plastic micro-CE chips capable of performing multiple-wavelength fluorescence detection by means of multimode optic fiber pairs embedded downstream of the separation channel. For detection purposes, the fluorescence signals are enhanced by positioning microfocusing lens structures at the outlets of the excitation fibers and the inlets of the detection fibers, respectively. The proposed device is capable of detecting multiple samples labeled with different kinds of fluorescent dyes in the same channel in a single run. The experimental results demonstrate that various proteins, including bovine serum albumin and beta-casein, can be successfully injected and detected by coupling two light sources of different wavelengths to the two excitation optic fibers. Furthermore, the proposed device also provides the ability to measure the speed of the samples traveling in the microchannel. The developed multiwavelength micro-CE chip could have significant potential for the analysis of DNA and protein samples.

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Theoretical and experimental investigations of the optical waveguiding properties of on-chip microfabricated capillaries

Cited by 19 publications

References 0 publications

Micro flow cytometers with buried SU-8/SOG optical waveguides

Micro flow cytometers with buried SU-8/SOG optical waveguides

nm- andμm-Scale Surface Roughness on Glass with Specific Optical Scattering Characteristics on Demand

A microfabricated capillary electrophoresis chip with multiple buried optical fibers and microfocusing lens for multiwavelength detection

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