We present a combined experimental-theoretical study of the energy loss of C and O ions in Zn in the energy range 50-1000 keV/amu. This contribution has a double purpose, experimental and theoretical. On the experimental side, we present stopping power measurements that fill a gap in the literature for these projectiletarget combinations and cover an extended energy range, including the stopping maximum. On the theoretical side, we make a quantitative test on the applicability of various theoretical approaches to calculate the energy loss of heavy swift ions in solids. The description is performed using different models for valence and inner-shell electrons: a nonperturbative scattering calculation based on the transport cross section formalism to describe the Zn valence electron contribution, and two different models for the inner-shell contribution: the shellwise local plasma approximation (SLPA) and the convolution approximation for swift particles (CasP). The experimental results indicate that C is the limit for the applicability of the SLPA approach, which previously was successfully applied to projectiles from H to B. We find that this model clearly overestimates the stopping data for O ions. The origin of these discrepancies is related to the perturbative approximation involved in the SLPA. This shortcoming has been solved by using the nonperturbative CasP results to describe the inner-shell contribution, which yields a very good agreement with the experiments for both C and O ions. The study of the energy loss of ions in solids is a problem of interest for basic and applied research in many areas, such as ion implantation, radiation damage, and space research. Although a large number of experiments and calculations have been produced over the years, there is a demand for new data for various projectile-target combinations. Additionally, the development of a consistent theoretical framework is a subject of great current interest [1,2]. In recent years, we have performed a set of studies that combine experimental and theoretical research with the aim of providing a theoretical framework that could serve as a basis for more accurate predictions of the energy loss of swift ions in various solid materials. It is worthwhile to mention that for ions heavier than Li, the experimental stopping power data are scarce except for some particular materials (C, Al, Si, Ag, Au) [3]. In zinc, no energy loss measurements for C and O ions have been reported in the literature.In previous papers, we have studied in a systematic way the stopping coefficients for a series of ions of increasing atomic numbers: H, He, Li, Be, and B in zinc [4][5][6][7][8], and with our theoretical formulation, we have been able to explain changes in the stopping power curves, reaching a very good agreement between the experimental and theoretical results. This agreement was achieved by a detailed theoretical study of the contribution of each individual charge state of the projectile and each electronic shell of the target. This was made by separ...