Theoretical and experimental study of the effects of scale-up on mixing time for a stirred-tank bioreactor

Bonvillani, P.; Ferrari, Miriam; Ducrós, Edith; Orejas, Joaquín

doi:10.1590/s0104-66322006000100001

Cited by 30 publications

(13 citation statements)

References 6 publications

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“…Mixing Time Measurement. Mixing time was measured using the pH-response technique (Bonvillani et al, 2006;Cascaval et al, 2004;Hadjiev et al, 2006). Mixing time was defined as the time taken for a system to mix to a prescribed final state of a mixture and is represented by degree of homogeneity.…”

Section: Methodsmentioning

confidence: 99%

Optimization of Energy Consumption and Mass Transfer Parameters in a Surface Aeration Vessel

Mohammadpour

Ma²,

Ebrahimzadeh³

et al. 2016

Water Environment Research

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This paper reports tests on a lab-scale surface aeration vessel was equipped with a Rushton turbine to examine its performance in terms of standard aeration efficiency (SAE), mixing time, and void fraction characteristics. These characteristics were investigated by tests using variations of rotor speed, impeller immersion depth, and water level. Results showed that variation of impeller immersion depth had a greater effect on the SAE compared to variation of water level. Moreover, the SAE increased with rotor speeds up to about 150 to 200 rpm and then decreased. In addition, void fraction improved by impeller immersion depth and rotor speed enhancement; however, mixing time and power number were reduced as rotor speed increased. According to the response surface methodology statistical optimizations, optimum values for rotor speed, impeller immersion depth, and water level were 168.90 rpm, 25 mm, and 30 cm, respectively, to achieve the maximum value of SAE.

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Section: Methodsmentioning

confidence: 99%

Optimization of Energy Consumption and Mass Transfer Parameters in a Surface Aeration Vessel

Mohammadpour

Ma²,

Ebrahimzadeh³

et al. 2016

Water Environment Research

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“…The studies on hydrodynamics have been focused in recent decades on a better understanding of the complex effects generated by two Rushton-impeller-stirred tanks. Practical applications of the double-Rushton mixer have been researched for several years [4][5][6][7][8][9][10] The comparison of the multipleand the single-impeller-based agitation systems with a special focus on their bioprocessing applications was presented in Ref. [11].…”

Section: Feature Descriptionmentioning

confidence: 99%

Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems

et al. 2020

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Biotechnological processes involving the presence of microorganisms are realized by using various types of stirred tanks or laboratory-scale dual-impeller commercial bioreactor. Hydrodynamics and mass transfer rate are crucial parameters describing the functionality and efficiency of bioreactors. Both parameters strictly depend on mixing applied during bioprocesses conducted in bioreactors. Establishing optimum hydrodynamics conditions for the realized process with microorganisms maximizes the yield of desired products. Therefore, our main objective was to analyze and define the main operational hydrodynamic parameters (including flow field, power consumption, mixing time, and mixing energy) and mass transfer process (in this case, gas–liquid transfer) of two different commercial bioreactors (BioFlo® 115 and BioFlo® 415). The obtained results are allowed using mathematical relationships to describe the analyzed processes that can be used to predict the mixing process and mass transfer ratio in BioFlo® bioreactors. The proposed correlations may be applied for the design of a scaled-up or scaled-down bioreactors.

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“…The mixing time was measured using the pH-response technique [15], [16]. The mixing time is defined as the time that the system requires to mix to a prescribed final state of mixture represented by the degree of homogeneity.…”

Section: B Mixing Time Measurementmentioning

confidence: 99%

Evaluation and Optimization of Efficiency and Mixing Time in a Surface Aeration Tank

Mohammadpour¹,

Akhvan-Behabadi²,

Nosrati³

et al. 2015

IJCEA

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Abstract-In this paper, a lab-scale aerated vessel equipped with a surface aeration impeller was developed to examine standard aeration efficiency (SAE) and mixing time. The SAE and mixing specifications were investigated via variations in the operating parameters, such as rotor speed, impeller immersion depth and water height. Surface aeration was performed using a Rushton disk turbine. Results showed that variation of impeller immersion depth has a greater effect on SAE compare to changes in water level. Moreover, SAE increases with rotor speed up to about 150 to 200 rpm and then decrease. In addition, mixing time is reduced with increase in rotor speed. According to the Response surface methodology (RSM) statistical optimization, optimum values of 169 rpm, 25 mm and 30 cm were found for rotor speed, impeller immersion depth and water height respectively in the range of this study to achieve the maximum value of SAE.

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Theoretical and experimental study of the effects of scale-up on mixing time for a stirred-tank bioreactor

Cited by 30 publications

References 6 publications

Optimization of Energy Consumption and Mass Transfer Parameters in a Surface Aeration Vessel

Optimization of Energy Consumption and Mass Transfer Parameters in a Surface Aeration Vessel

Hydrodynamics and Mass Transfer Analysis in BioFlow® Bioreactor Systems

Evaluation and Optimization of Efficiency and Mixing Time in a Surface Aeration Tank

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