Many mathematical problems of natural symptoms whose mathematical models can be formulated in the form of differential equations. Because the problem is complex, students need to develop their thinking skills, one of which is critical thinking. This study aims to describe students' mathematical critical thinking ability in solving the problem of the application of first-order differential equations. The method used in this study is descriptive qualitative. The subject of this study was a 6th-semester student of Indraprasta PGRI Indraprastha, with as many as three people. The selection of subjects is donetopicsosive sampling, based on the results of pretests. The instruments used are critical thinking skills tests (pretest and posttest questions), interview guidelines, and researchers. Data analysis techniques are carried out through data reduction, presentation of data, and verification. The results showed that there were student's critical thinking ability in solving problems of applying first-order differential equations, especially in subjects with high (L6) and moderate pretest (M9) results that met all indicators. However, issues with low pretest results (L2), from the three questions given, could only work on one question and did not fulfill the critical thinking indicators in the other two questions.