Theoretical Bounds and System Design for Multipinhole SPECT

Nillius, Peter; Danielsson, Mats

doi:10.1109/tmi.2010.2047113

Cited by 30 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To determine the optimal configuration of our high space-bandwidth scintillation detectors, this study used a theoretical optimization method [23]. The resulting 'optimal' systems were simulated and good sampling was demonstrated.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Design and performance of a compact and stationary microSPECT system

et al. 2013

View full text Add to dashboard Cite

Purpose: Over the past ten years, there has been an extensive growth in the development of microSPECT imagers. Most of the systems are based on the combination of conventional, relatively large gamma cameras with poor intrinsic spatial resolution and multi-pinhole collimators working in large magnification mode. Spatial resolutions range from 0.58 to 0.76 mm while peak sensitivities vary from 0.06% to 0.4%. While pushing the limits of performance is of major importance, we believe that there is a need for smaller and less complex systems that bring along a reduced cost.While low footprint and low-cost systems can make microSPECT available to more researchers, the ease of operation and calibration and low maintainance cost are additional factors that can facilitate the use of microSPECT in molecular imaging. In this paper, we simulate the performance of a microSPECT imager that combines high space-bandwidth detectors and pinholes with truncated projection, resulting in a small and stationary system. Methods:A system optimization algorithm is used to determine the optimal SPECT systems, given our high resolutions detectors and a fixed field-of-view. These optimal system geometries are then used to simulate of a Defrise disk phantom, a hot rod phantom. Finally, a MOBY mouse phantom, with realistic concentrations of Tc99m-tetrofosmin is simulated.Results: Results show that we can successfully reconstruct a Defrise disk phantom of 24 mm in diameter without any rotating system components or translation of the object. Reconstructed spatial resolution is approximately 800 µm while the peak sensitivity 0.23%. Finally, the simulation of the MOBY mouse phantom shows that we can accurately reconstruct mouse images. Conclusions:These results show that pinholes with truncated projections can be used in small magnification or minification mode to obtain a compact and stationary microSPECT system. We showed that we can reach state-of-the-art system performance and that we can successfully reconstruct images with realistic noise levels in a pre-clinical context. Such a system can be useful for dynamic SPECT imaging. * Roel.VanHolen@UGent.be 2

show abstract

Section: Discussionmentioning

confidence: 99%

“…For system optimization, we refer to Nillius and Danielson [23]. Others have published 95 multi-pinhole SPECT optimization procedures for human brain imaging [16].…”

Section: B System Optimizationmentioning

confidence: 99%

Design and performance of a compact and stationary microSPECT system

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Table I shows the tested configuration parameters, including the n, D, F, multiplexing degree (MUX), pinhole diameter (d), and open angle of the pinhole (α). The initial spatial resolution (R 0 ) and sensitivity (S 0 ) can be calculated by the geometric analytic model [9]:…”

Section: A Determination Of the Magnification And The Number Of Pinhmentioning

confidence: 99%

“…Subsequently, the AUC of the designed multi-pinhole micro-SPECT can be evaluated with the simulated human observer. Besides, the spatial resolution is estimated by the Fourier crosstalk calculations as described in [9]. Moreover, a hot-rod phantom as shown in Fig.…”

Section: Evaluation Of the System Performancementioning

confidence: 99%

Configuration optimization for multi-pinhole micro-SPECT systems by signal detection tasks and system performance evaluations

Lee

Lin

Chen

2013

2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC)

View full text Add to dashboard Cite

An optimized multi-pinhole aperture can improve the spatial resolution and the sensitivity of pinhole SPECT system simultaneously. In this study, an optimization strategy of the multi-pinhole configuration is proposed, including the preliminary evaluations by geometric analytic models and the system performance evaluations by a simulated human observer, the Fourier crosstalk approach and tomographic image reconstructions. According to the resulting AUC, sensitivity, spatial resolution and reconstructions, a 4-pinhole aperture with 20% multiplexing and 1.52X magnification is the optimized configuration for a micro pinhole-SPECT with a camera with an active area of 49 × 49 mm 2 and a 14-mm diameter spherical fieldof-view.

show abstract

“…In order to determine the optimal MPH collimator design, Nillius et al [2] proposed an analytical model and showed that the image quality in terms of resolution and detection efficiency are related to several parameters: the diameter of FOV (d), radii-of-rotation (I), collimator length (L I), detector intrinsic resolution (R,) and the size of the active detector area (A). Those MPH collimator configuration parameters can be determined for a given system resolution (R,) and FOV (d) in order to optimize the detection efficiency (S).…”

Section: Designmentioning

confidence: 99%

Design of an optimized multi-pinhole collimator for dual-purpose clinical and preclinical imaging

Si¹,

Mok²

2012

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC)

View full text Add to dashboard Cite

Pinhole SPECT provides superior trade-off between resolution and detection efficiency as compared to parallel-hole collimator for imaging small field-of-view. Previously we proposed an adjustable multi-pinhole (MPH) collimator for clinical myocardial perfusion imaging (MPI) and small animal imaging (SAl) of rats, based on a clinical SPECT/CT scanner. This study aims to optimize and evaluate this MPH collimator design. For MPI and SAl, the target resolutions were set to 1 cm and 1 mm, the FOVs were 20 cm and 5 cm, and the radii-of rotation were 25 cm and 5 cm, respectively. The maximum detector-to-detector distance for the scanner was 76 cm. Based on the work from Rentmeester et al., Nillius et al. and the system constraints, we optimized the detection efficiency and calculated the design parameters as follows: (i) MPI: 18 knife-edge pinholes with 2.61 mm aperture size, 13 cm collimator length; (ii) SAl: 4 knife-edge pinholes with aperture size of 0.41 mm, 20.8 cm collimator length. All pinholes were focused to the center of FOV.The proposed collimator was composed of two parts: a base cone with a height of 13 cm for MPI and an auxiliary cone with a height of 7.8 cm that can be combined with the base cone for SAl.The pinholes were placed in a way to utilize the whole detector, minimize projection truncation and keep the multiplexing <25%. Tc-99m point source simulations, using GATE (Geant4 Application for Emission Tomography) were performed for different imaging distances to compare the detection efficiency and resolution between low-energy-high-resolution (LEHR) parallel-hole and MPH collimator. For MPI, the measured FWHMs were 11.70 mm and 9.02 mm for LEHR and MPH respectively, while the detection efficiency of MPH had 17.5 % improvement as compared to LEHR. For SAl, the FWHMs for LEHR and MPH were 4.92 mm and 1.01 mm respectively. The new collimator has improved the imaging performance as compared to our previous design. It provides a significant improvement in resolution and detection efficiency trade-off as compared to current MPI using LEHR with extra capability for SAl.

show abstract

Theoretical Bounds and System Design for Multipinhole SPECT

Cited by 30 publications

References 24 publications

Design and performance of a compact and stationary microSPECT system

Design and performance of a compact and stationary microSPECT system

Configuration optimization for multi-pinhole micro-SPECT systems by signal detection tasks and system performance evaluations

Design of an optimized multi-pinhole collimator for dual-purpose clinical and preclinical imaging

Contact Info

Product

Resources

About