Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric fields

Kotnik, Tadej; Miklav?i?, Damijan

doi:10.1002/1521-186x(200007)21:5<385::aid-bem7>3.0.co;2-f

Cited by 152 publications

(52 citation statements)

References 22 publications

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“…The results showed peculiar current density peaks at the raft-membrane interface due to the high permittivity and conductivity of the lipid raft domain. Strong electric loss can be discovered in the local environment of the membrane raft based Membrane (5nm) ε r =2, μ=1, σ=3*10 -7 S/m [42] Membrane raft (5nm) ε r =40, μ=1, σ=3*10 -6 S/m [43,44] Background ε r =1, μ=1, σ=0 S/m on computer simulations ( Figure 13). One order of magnitude loss differences are generated at the cell membranes by the lateral inhomogeneity.…”

Section: Live Cell Imagingmentioning

confidence: 95%

Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model

et al. 2015

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IntroductionLiving tissue is complexly heterogenic. The processes are mostly chemical reactions, where energy absorption-emission is a central point. The energy liberated by metabolic activity appears in the bodytemperature, which is also very heterogenic by its sources, but is averaged by natural heat-conduction and the connected temperature equalisation. Hyperthermia is a thermal process, defined by a temperature-elevation in the target [1]. The mass-or volume-specific energy absorption (defined by the specific absorption rate [SAR]) increases the temperature.In the definition of hyperthermia, temperature is the obligatory parameter, used for dosing by considering the time for which it was effective [2]. Consequently, the treatment has to be identified by temperature, or at least by the specific energy absorption rate (SAR) in the target. The temperature and the energy-deposition must therefore be controlled.Electromagnetic energy delivery could be by four not completely independent categories, depending on the coupling of the fields to the object; it could be radiation, inductive, capacitive or galvanic coupling [3,4]. All of the interactions have variability in their absorption processes [5], in addition to the structural variations. Consequently, the SAR has microscopic medley values in the living target.Temperature is the average energy of the particles involved in the absorption process. This general temperature is composed of the various different microscopic heating areas, which could be equalised by the heat-conduction and convection in their surroundings by various timecharacters. The macroscopic temperature is a gross-average of all of the microscopic temperatures and their spread-processes.There are some very high-temperatures (over the protein denaturation [6] that can be locally concentrated and are relatively short time applications. It is limited to a very small volume by various interstitial methods, including the most popular radiofrequency (RF) ablation techniques. However, most of the hyperthermia practices in oncology are locally or regionally devoted to solving hyperthermia effects in shallow and deep-seated tumours [4]. The problems in these methods are simply connected to the focusing of heat-energy. The energy can be focused by choosing the targeted volume, but due to the non-invasive solutions, the input power is limited by adverse effects, so longer duration is necessary to heat up the target. The longer heating time completely changes the situation; we have to take into account the natural movements of the patient, which heats up the healthy environment, and naturally occurs because of the effective heat-diffusion and heat-conduction in the body. The energy can be focused for longer times to a chosen target volume, but the heat (and the temperature) is not focusable for longer, as it naturally spreads.The consequences of heat spreading can dramatically change the complete hyperthermia process. The homeostatic regulation of the body tries to re-establish the homeostatic equilibrium. C...

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Section: Live Cell Imagingmentioning

confidence: 95%

Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model

et al. 2015

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“…Then the membrane depolarization DV is proportional to the DC electric field with amplitude E 0 . Recently, the transmembrane voltage component DV induced by DC electric field (Kotnik et al 1998 andMiklavcic 2000) takes the following form:…”

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confidence: 87%

Synchronization of neuron population subject to steady DC electric field induced by magnetic stimulation

Wang

Deng

et al. 2012

Cogn Neurodyn

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Electric fields, which are ubiquitous in the context of neurons, are induced either by external electromagnetic fields or by endogenous electric activities. Clinical evidences point out that magnetic stimulation can induce an electric field that modulates rhythmic activity of special brain tissue, which are associated with most brain functions, including normal and pathological physiological mechanisms. Recently, the studies about the relationship between clinical treatment for psychiatric disorders and magnetic stimulation have been investigated extensively. However, further development of these techniques is limited due to the lack of understanding of the underlying mechanisms supporting the interaction between the electric field induced by magnetic stimulus and brain tissue. In this paper, the effects of steady DC electric field induced by magnetic stimulation on the coherence of an interneuronal network are investigated. Different behaviors have been observed in the network with different topologies (i.e., random and small-world network, modular network). It is found that the coherence displays a peak or a plateau when the induced electric field varies between the parameter range we defined. The coherence of the neuronal systems depends extensively on the network structure and parameters. All these parameters play a key role in determining the range for the induced electric field to synchronize network activities. The presented results could have important implications for the scientific theoretical studies regarding the effects of magnetic stimulation on human brain.

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“…Concerning cell dielectric properties, the description by a constant permeability and a constant conductivity is relevant in the range from 1,000 Hz to 10 7 Hz (Kotnik and Miklavčič, 2000). The two main domains (cytoplasm and membrane) of a cell present a high contrast (Table 1) and play the most significant roles in the global dielectric behavior of the cell.…”

Section: Electromagnetic Characteristicsmentioning

confidence: 99%

Electromagnetic characterization of biological cells

Buret¹,

Haddour²,

Laforet-Ast³

et al. 2011

RBEB

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This paper presents the most commonly used method to characterize individual biological cells on a dielectric point of view. It is a force based technique which lays on dielectrophoresis and/or electrorotation. First the principle of these phenomena are described and analyzed with an extension to magnetic forces at the micrometric scale level. Secondly we present an experimental setup which permits to acquire the dielectrophoretic spectrum which is a dielectric signature of a cell. The main dielectric parameters can be deduced by fitting the theoretical response of the cell issued from a dielectric model and the experimental data. At the end we present an improved fitting method which takes advantage of a sensitivity analysis based on a probabilistic approach.Keywords Biological cell, Magnetophoresis, Dielectro phoresis, Electrorotation, Electromagnetic characterization, Parameter extraction. Caracterização eletromagnética de células biológicas Resumo Este trabalho apresenta um dos métodos mais utilizados para caracterização de células biológicas individuais sob o ponto de vista dielétrico. É uma técnica baseada na força produzida por células submetidas a campos magnéticos ou elétricos. Inicialmente, os princípios associados a estes fenômenos são descritos e analisados,

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Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric fields

Cited by 152 publications

References 22 publications

Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model

Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model

Synchronization of neuron population subject to steady DC electric field induced by magnetic stimulation

Electromagnetic characterization of biological cells

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