The article contains an analysis of the Russian knowledge-based economy at the meso-economic (regional) level in the period from 2005 to 2015. Authors assess the main parameters of the development of the constituent entities of the Russian Federation, including the regional innovation system and the education system, ICT infrastructure and environmental conditions of life. It has been proven that the background of the knowledge-based economy in Russia (ICT and the ecological environment) is characterized by a converging trend, and the core of the knowledge-based economy (the educational system and the innovation system) is characterized by a divergent trend. Differentiation of education systems in the Russian regions increases during 10 years of analysis, therefore, the ability of peripheral regions to switch to knowledge-intensive is steadily decreasing. The gap between leaders and outsiders (the overwhelming majority of regions) of the development of a regional innovation system is maximum. Authors conclude that the preservation of a liberal-oriented meso-economic policy in Russia will contribute to the formation of an asymmetric model of the knowledge-based economy.