Theoretical lateral and axial sensitivity limits and choices of molecular reporters for Cherenkov-excited luminescence in tissue during x-ray beam scanning

LaRochelle, Ethan; Pogue, Brian W.

doi:10.1117/1.jbo.25.11.116004

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…The Rayleigh scattering process samples the polar angle phase function based upon the following relationship [16]:…”

Section: Sheet Monte Carlo and Imaging Configurementioning

confidence: 99%

A Monte Carlo study for excitation field in Cherenkov-excited luminescence scanned tomography

Zhang,

HU,

et al. 2024

Molecular-Guided Surgery: Molecules, Devices, and Applications X

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Cherenkov-Excited Luminescence Scanned Tomography (CELST) involves a system of coupled continuous wavedomain diffusion equations for modeling. The excitation field quantized by the Complex Cosine (CC) method effectively simulates the forward light process in these equations. However, when considering x-ray-induced Cherenkov light within biological tissue, the CC-based excitation field lacks precision, instead requires the use of stochastic Monte Carlo (MC) methods. To accurately describe the radiation-induced light transport in biological tissue and CELST image reconstruction, in this paper, we develop a MC-based method for CELST, named sheet Monte Carlo (sMC). Experiments show that the sMC field can achieve 11.47 on contrast-to-noise ratio (CNR) and 0.74 on Pearson correlation (PC), while 7.25 and 0.57 for the CC initialization field under 4% noise level. Furthermore, our results highlight that the proposed excitation field exhibits superior reconstruction performance, especially when dealing with low ratios of fluorescent targets.

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“…The Rayleigh scattering process samples the polar angle phase function based upon the following relationship [16]:…”

Section: Sheet Monte Carlo and Imaging Configurementioning

confidence: 99%

A Monte Carlo study for excitation field in Cherenkov-excited luminescence scanned tomography

Zhang,

HU,

et al. 2024

Molecular-Guided Surgery: Molecules, Devices, and Applications X

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show abstract

“…Lateral resolution is limited by the ability to slice or focus the x-ray beam, as illustrated by Monte Carlo simulations of at 6-and 18-MV beams (d), where the beam is directed downward and the X -Y axes show the mm dimensions into the tissue and the color bar is a Cherenkov intensity scale. 42 The final lateral spatial resolution can be deconvolved with the beam width, show sensitivity to sub-millimeter objects, as illustrated in (e) where thin luminescent capillaries of varying diameter, d, were used to show sensitivity to resolve the full width at half maximum (FWHM) down to 0.2-mm diameter. 33 The FWHM is a convolution of the beam width with d.…”

Section: Multiplexing Of Signalsmentioning

confidence: 99%