Theoretical prediction of the chemiluminescence behaviour of the ergot alkaloids

Martí, E. Polo; Catalá-Icardo, Mónica; Zamora, Luis Lahuerta; Fos, G.M. Antón; Calatayud, J. Martı́nez

doi:10.1016/j.aca.2004.07.026

Cited by 19 publications

(5 citation statements)

References 23 publications

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“…There are many reports of chemiluminescence from the reaction of various organic compounds with oxidants such as cerium(IV),94–96 hexacyanoferrate(III),97, 98 and hypohalites 3, 99. Unlike permanganate and manganese(IV) in acidic solution, the emitting species in these reactions often appears to be derived from the organic analyte, or generated by energy transfer from a reaction intermediate to a more efficient luminophore (e.g.…”

Section: Chemiluminescence and Electrochemiluminescence Reactionsmentioning

confidence: 99%

“…Using FIA methodology, Polo Martí et al , examined chemiluminescence reactions between the ergot alkaloid ergotamine and various oxidants in acidic and alkaline solution and found that potassium hexacyanoferrate(III) in alkaline solution gave the greatest signal intensities 98. Further improvements were made by adding dioxane to the sample and increasing the reaction temperature to 70 °C.…”

Section: Halucinogensmentioning

confidence: 99%

“…The limit of detection was reported to be 1 × 10 −12 M. The optimized procedure was also applied to methylergonovine and dihydroergocristine. Calculations based on molecular connectivity suggested that various other ergot alkaloids, including lysergic acid diethylamide (Figure 21g), would also be chemiluminescent 98…”

Section: Halucinogensmentioning

confidence: 99%

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Chemiluminescence and electrochemiluminescence detection of controlled drugs

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Barnett

et al. 2010

Drug Testing and Analysis

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We review the determination of various controlled drugs (opioids, tranquilizers, stimulants, and hallucinogens) using flow-analysis methodologies (flow injection analysis, high performance liquid chromatography, capillary electrophoresis, and microfluidic devices) with chemiluminescence and electrochemiluminescence reagents such as luminol, diaryloxalates, tris(2,2'-bipyridine)ruthenium(II), permanganate, manganese(IV), and sulfite, for industrial, clinical, pharmaceutical, and forensic science applications.

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Section: Chemiluminescence and Electrochemiluminescence Reactionsmentioning

confidence: 99%

Section: Halucinogensmentioning

confidence: 99%

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Chemiluminescence and electrochemiluminescence detection of controlled drugs

Adcock

Barrow

Barnett

et al. 2010

Drug Testing and Analysis

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“…Various detection methods to determine EGT either alone or in combination with other pharmaceuticals in diverse sample matrices were found by a thorough literature survey. Spectrofluorimetry [ 5 ], flow injection analysis [ 6 , 7 ], and “high-performance liquid chromatography (HPLC)” methodologies [ 8 ] have been utilized to detect EGT in various samples. HPLC approaches are also identified to determine EGT in combination with metoclopramide, caffeine, and paracetamol in combined dosage forms [ 2 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Rapid and Sensitive Stability-Indicating Eco-Friendly HPTLC Assay for Fluorescence Detection of Ergotamine

et al. 2023

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Eco-friendly liquid chromatographic methods for measuring ergotamine (EGT) are scant in the published database. Accordingly, the goal of the current study was to develop a high-performance thin-layer chromatography (HPTLC) method for fluorescence detection of EGT in commercially available tablets. This approach was based on the application of ethyl alcohol–water (80:20 v/v) as the eco-friendly eluent mixture. The fluorescence detection of EGT was carried out at 322 nm. The greenness score of the present approach was evaluated by “Analytical GREENness (AGREE)” technology. The present approach for measuring EGT in the 25–1000 ng band−1 range was linear. The present assay for fluorescence detection of EGT was validated successfully by ICH guidelines for various parameters. The method was found to be rapid, sensitive, eco-friendly, and stability-indicating. The computed AGREE index for the current strategy was 0.84, displaying outstanding greenness features. The present methodology successfully separated the EGT degradation products under forced-degradation circumstances, exhibiting its stability-indicating qualities and selectivity. An amount of 99.33% of EGT was found in commercial formulations, indicating the validity of the current method for pharmaceutical analysis of EGT in commercial products. The results showed that EGT in commercial products might be regularly measured by the existing method.

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“…In the last years, several methodologies have been developed for ergotamine determination in diverse samples including Flow-Injection (FI) Chemioluminiscence [8], FI-Fluorimetry [9], Gas-chromatography [10], Spectrofluorimetry [11], Liquidchromatography [12] and Radioinmunoassay [13]. The high native fluorescence of ergotamine in aqueous solution has led to the development of several fluorimetric methodologies for its quantification or applied as detection system.…”

Section: Introductionmentioning

confidence: 99%