An eQUEST model was developed to conduct a study of a natural gas engine driven heat pump (GEHP) for an office building in Woodstock, Ontario. The results were also compared with a roof-top unit to investigate annual potential energy saving using GEHP. The models were also calibrated with regression analysis which was obtained from measured data and validated with respect to ASHRAE Guideline 14-2002. The developed ad validated models were used to predict the performance of these system in different regions of Ontario; Toronto, Ottawa, Windsor and Thunder Bay. The results for five cities were compared in terms of annual energy, GHG and energy cost savings. It was concluded that Thunder Bay has the highest annual energy and GHG saving, while Toronto has the highest annual energy cost saving.