Theoretical studies on the pyrolysis of (Thion)carbonates

Wu, Peng; Li, Jiaxing

doi:10.1142/s0219633614500515

Cited by 7 publications

(2 citation statements)

References 54 publications

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“…12,14,[23][24][25][26] However, studies on the toxicology of nanoscale DTX were not clear enough, especially on reproductive toxicity. Through this study, we have provided evidences supporting the hypothesis that NP delivery systems could reduce the reproductive toxicity of DTX in rodents.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle Delivery Systems Reduce the Reproductive Toxicity of Docetaxel in Rodents

et al. 2014

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Various docetaxel (DTX)-loaded nanoparticle delivery systems have been designed to enhance the solubility and pharmacological e®ects of DTX. However, the toxicity changes of these nano-modi¯ed DTX (nano-DTX) are not yet clear enough. Herein, to compare the reproductive toxicity between conventional DTX and nano-DTX, we performed sperm toxicity test in mice, and fertility and early embryo-fetal developmental toxicity test in rats. It was found that DTX severely repressed spermatogenesis and sperm motility, and dramatically increased sperm abnormality in mice and rats. Moreover, DTX signi¯cantly decreased copulation, conception and fertility indexes in rats, and no positive pregnant female rat was obtained after treatment with DTX. However, nano-DTX signi¯cantly reduced DTX-induced toxicity to sperm. Most importantly, nano-DTX obviously converted DTX-induced fertility and early embryo-fetal developmental toxicity. Furthermore, organ weights and histopathology examination revealed DTX, but not nano-DTX, signi¯cantly decreased testis and epididymis weights, and induced obvious histopathological atrophy of testes and epididymides in rats. Further studies indicated that changed activity of lactate dehydrogenase C4 (LDH-C4) in rodents testes was mainly responsible for the above observations. These results strongly support the idea that DTX-loaded nanoformulations have the potential to overcome the reproductive toxicity of DTX.

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Section: Discussionmentioning

confidence: 99%

Nanoparticle Delivery Systems Reduce the Reproductive Toxicity of Docetaxel in Rodents

et al. 2014

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“…The generated mass-loss curves for blends are checked against the experimental data for any differences that may be used as evidence of synergistic effects attributed to coal/algae interactions. The application of computers and their software in modelling and simulation has already been demonstrated by a number of researchers in their different fields of study (Csukás et al 2013;Nyoni et al 2017;Wu and Li 2014). Secondly, a kinetic study on the co-pyrolysis of coal and algae is carried out.…”

Section: Introductionmentioning

confidence: 99%

Co-pyrolysis of South African bituminous coal and Scenedesmus microalgae: Kinetics and synergistic effects study

Nyoni

Duma

Bolo

et al. 2020

Int J Coal Sci Technol

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In this work, the co-pyrolysis of coal and algae is explored with special emphasis on decomposition kinetics and the possibility of the existence of synergistic effects. Modelling and kinetics analysis based approaches were used for the investigation of the existence of synergistic effects. The co-pyrolysis kinetics was studied using the model-free, Coats–Redfern integral method. The kinetics were evaluated for 1st and 2nd order reaction models. Results reveal that Scenedesmus microalgae is characterised by a two stage decomposition process that occurs at temperature ranges of 200–400 °C and 500–700 °C with activation energy of 145.5 and 127.3 kJ/mol, respectively. Bituminous coal has a two stage, slow decomposition process that occurs at temperature ranges of 400–700 °C and above 750 °C with an activation energy of 81.8 and 649.3 kJ/mol, respectively. Furthermore, co-pyrolysis of coal and microalgae is characterised by three stages whose kinetics are dominated by the pyrolysis of the individual materials. For the studied range of coal/algae ratios, the three pyrolysis stages occur in the approximate temperature ranges of 200–400 °C, 430–650 °C and above 750 °C, with activation energies in the ranges of 131–138, 72–78 and 864.5–1235 kJ/mol, respectively. Modelling and kinetics study showed that there is strong evidence of interactions between coal and microalgae that manifest as synergistic effects especially in the second and third stages of decomposition.

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Theoretical study of the mechanism generating azomethine ylide from formaldehyde and glycine

2015

J Struct Chem

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Theoretical studies on the pyrolysis of (Thion)carbonates

Cited by 7 publications

References 54 publications

Nanoparticle Delivery Systems Reduce the Reproductive Toxicity of Docetaxel in Rodents

Nanoparticle Delivery Systems Reduce the Reproductive Toxicity of Docetaxel in Rodents

Co-pyrolysis of South African bituminous coal and Scenedesmus microalgae: Kinetics and synergistic effects study

Theoretical study of the mechanism generating azomethine ylide from formaldehyde and glycine

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