Theoretical study of the hydrogen bonding interaction between Levodopa and a new functionalized pillared coordination polymer designed as a carrier system

Arenzano, Jesús A.; Campo, Jorge M. del; Virues, Jorge O.; Ramirez-Montes, Pedro I.; Santillán, Rosa; Rivera, José María

doi:10.1016/j.molstruc.2014.11.042

Cited by 5 publications

(5 citation statements)

References 36 publications

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“…Theoretical studies have already been made to investigate the strength of the hydrogen bonding between the COOH group of Levodopa and the NH2 group belonging to a functionalized pillared coordination polymer. The results obtained suggest the possibility to employ such materials as carrier systems because the NH2 group can form strong hydrogen-bonding interactions with any electron acceptor groups (16).…”

mentioning

confidence: 89%

Trypanocidal Effect of Nano MOFs-EP on Circulating Forms of Trypanosoma cruzi

Morales-Baez

Rivera

López‐Monteon

et al. 2020

IJPA

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Background: Chagas disease caused by the parasite Trypanosoma cruzi is considered a neglected disease in several countries. One of the main problems about this disease is the lack of an effective treatment and the absence of adverse effects. T. cruzi, like most pathogenic fungi and yeasts, require specific sterols to maintain viability and proliferative capacity during their life cycle. However, the oxidation of this molecule to ergosterol peroxide has shown several biological effects, including its trypanocidal activity. Methods: We have synthesized MOFs nanoparticles as carrier system coupled to ergosterol peroxide (MOFs-EP) and we have studied its effect on the circulating forms of the T. cruzi parasite. Results: MOFs-EP possess an efficient trypanocidal activity at much lower inhibitory concentrations (ng/mL) that the concentrations shown by ergosterol peroxide (g/mL) when administered unconjugated form. Conclusion: Our results open a new possibility in the biomedical application of MOFs and ergosterol peroxide in the search for new options for the treatment of Chagas disease.

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mentioning

confidence: 89%

Trypanocidal Effect of Nano MOFs-EP on Circulating Forms of Trypanosoma cruzi

Morales-Baez

Rivera

López‐Monteon

et al. 2020

IJPA

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“…Equimolar amount (1 : 1) of Copper Nitrate 1.208 g (0.005 M) and 5‐aminoisophthalic acid 0.9055 g (0.005 M) was taken. The choice of the ligand is based on the amine group‘s ability to form a complex with copper and its biocompatible nature [11,12] . Copper nitrate was dissolved in about 25 mL of water, and 5‐aminoisophthalic acid was dissolved in 25 mL of DMF.…”

Section: Methodsmentioning

confidence: 99%

“…The choice of the ligand is based on the amine group's ability to form a complex with copper and its biocompatible nature. [11,12] Copper nitrate was dissolved in about 25 mL of water, and 5-aminoisophthalic acid was dissolved in 25 mL of DMF. The suspension was stirred into a homogeneous mixture, transferred to a hydrothermal autoclave reactor, capped tightly, and placed in an oven at 110 °C for 12 hours.…”

Section: Synthesis Of Aipa-cu (Ii) Mofmentioning

confidence: 99%

Facile Synthesis of Copper‐5‐Aminoisophthalic Acid Metal Organic Framework as a Potential Drug Carrier for Ibuprofen

2022

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Due to their large surface area and porous nature, metal organic frameworks hold a promising application in drug delivery. Among several combinations of metals with organic linkers, copper as a metal possesses synergistic behavior in drug delivery due to its antibacterial, antioxidant properties, and other biological functional necessities. This study uses the copper-5-aminoisophthalic acid metal organic framework (AIPA-Cu (II) MOF) for drug delivery. From the experimental studies, AIPA-Cu (II) MOF exhibited a potentially good loading capacity of Ibuprofen drug and excellent controlled release in in-vitro drug release studies. The loading efficiency of Ibuprofen in AIPA-Cu (II) MOF has been confirmed using BET adsorption, X-Ray Diffraction, XPS spectroscopy, UV-Visible Spectroscopy, and IR spectroscopy by comparing it against unloaded AIPA-Cu (II) MOF. The uncoordinated free amino group in the 5aminoisophthalic acid ligand is expected to form an interaction between Ibuprofen and AIPA-Cu (II) MOF through van der Waals force to induce better loading. Thus, the current study opens up a new avenue for the potential usage of AIPA-Cu (II) MOF as an effective and compatible drug carrier for hydrophobic drugs like Ibuprofen.

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“…Metal-organic frameworks (MOFs) have been widely reported in the literature during the last two decades, and the number of articles published is exponentially increasing due to the opportunity to obtain a great diversity of novel crystalline porous materials with different topologies and most important with a countless number of applications in different fields of chemistry such as catalysis, photocatalysis, gas storage, separation, sorption, hydrogen evolution, and more [1][2][3][4][5][6][7][8][9]. pyrazolate and triazolate-based systems have been found to self-assemble with metal ions/clusters into neutral MOFs.…”

Section: Introductionmentioning

confidence: 99%

“…The distances between cobalt atoms are in the range from 7.34 Å to 7.14 Å. The material that possesses free functional NH 2 groups able to form hydrogen bonding interactions can be used as a carrier system [5].…”

Section: Introductionmentioning

confidence: 99%

Transition Metals-Based Metal-Organic Frameworks, Synthesis, and Environmental Applications

Chiñas-Rojas¹,

Vivar-Vera²,

Cruz-Martínez³

et al. 2022

Sorption - From Fundamentals to Applications

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This work illustrates examples of metal-organic frameworks (MOFs) derived from transition metals and their environmental applications in areas of catalysis, sorption, and hydrogen evolution. Explanation of some of the techniques employed for their synthesis has been discussed. On the other hand, the advantages of the use of hybrid materials such as the metal-organic frameworks are exposed in this book as well a detailed description of the different linkers and metals used for the synthesis of this kind of porous materials going through the methodologies and techniques utilized by different authors to obtain good-quality crystalline applicable materials. Adjustments of linker geometry, length, ratio, and the functional group can tune the size, shape, and internal surface property of an MOF for a targeted application. The uses of MOFs are exploring new different areas of chemistry such as catalysis, adsorption, carrier systems, hydrogen evolution, photocatalysis, and more. Different examples of MOFs from Scandium to Zinc are well described in this book, and finally, a brief description of some common environmental applications such as metals and azo dyes sorption, hydrogen evolution, and catalyst in the transesterification process of vegetable oils to produce biodiesel is explored and commented.

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Theoretical study of the hydrogen bonding interaction between Levodopa and a new functionalized pillared coordination polymer designed as a carrier system

Cited by 5 publications

References 36 publications

Trypanocidal Effect of Nano MOFs-EP on Circulating Forms of Trypanosoma cruzi

Trypanocidal Effect of Nano MOFs-EP on Circulating Forms of Trypanosoma cruzi

Facile Synthesis of Copper‐5‐Aminoisophthalic Acid Metal Organic Framework as a Potential Drug Carrier for Ibuprofen

Transition Metals-Based Metal-Organic Frameworks, Synthesis, and Environmental Applications

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