Theranostic Bioabsorbable Bone Fixation Plate with Drug‐Layered Double Hydroxide Nanohybrids

Abstract

A bioabsorbable polymeric bone plate enabled with both diagnostic and therapeutic functionalities (radiopacity and sustained drug release, respectively) is proposed. To this end, a drug-inorganic nanohybrid (RS-LDH) is examined as a theranostic agent by intercalating an anti-resorptive bone remodeling drug, risedronate (RS) into a layered double hydroxide (LDH) via an ion-exchange reaction. The RS-LDH is prepared as a sheet with a biodegradable polymer, poly(lactic-co-glycolic acid), and is then attached onto the clinically approved bioabsorbable bone plate to produce the theranostic plate. Because of the presence of the metals in the LDH, the theranostic plate results in discernible in vivo X-ray images for up to four weeks after implantation. Concurrently, bone regeneration is also significantly improved compared with the other control groups, likely because of this material's sustained drug-release property. The theranostic plate is also largely biocompatible, similar to the plate already approved for clinical use. It is concluded that the combination of a biodegradable bone plate with RS-LDH nanohybrids can constitute a promising system with theranostic ability in both X-ray diagnosis and expedited bone repair.

Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration

“…Three batches were tested for each sample type. We initially created a critically sized calvarial bone defect in rats, as previously reported by Spicer et al and Kim et al 39,40 . Rat anesthesia was induced using isoflurane, after which alfaxalone (ALFAXAN CIV 80 mg/kg) and xylazine (Rompun, 10 mg/kg) were injected intraperitoneally for deep anesthesia.…”

Hydrotalcite–Niclosamide Nanohybrid as Oral Formulation towards SARS-CoV-2 Viral Infections

“…The important reason for selecting HT as a nanocarrier was due to its well-known biocompatibility, according to our previous studies on developing drug delivery systems [44][45][46]. In addition, its muco-adhesion property is expected to be beneficial as well.…”

Ibuprofen Release from Hydrotalcite-like Materials Filled into Chitosan/Alginate Composites as Promising Reabsorbable Membranes

“…Assays by alkaline phosphatase activity and Alizarin Red staining indicated that the scaffold with 5% drug-loaded-LDH (Mn-Mg-LDH/PLGA/AT5%) induced a remarkably higher level of the markers compared to the PLGA scaffold 27 . In the Kim et al 28 study, a bioabsorbable polymeric bone plate was proposed to be enabled with both diagnostic and therapeutic functionalities. This study investigated a druginorganic nanohybrid (RS-LDH) where an anti-resorptive bone remodeling drug was intercalated into a layered double hydroxide (LDH) via an ion-exchange reaction.…”

“…The RS-LDH was added in poly(lactic-co-glycolic acid), a biodegradable polymer, and the results show a clinically approved bioabsorbable bone plate to produce the theranostic plate 28 . However, a study using Zn/Al LDH with different molar ratios intercalated with ibuprofen in chitosan and alginate films to bone treatment is rare.…”