Therapeutic Aerosol: Thermodynamic Method for Managing the Aerosol Particle Size

Olenev, Evgeny; Hamid, Marwan A. A.; Al-Haidri, Walid; Lebedinskaya, Elena

doi:10.1007/s41810-020-00069-z

Cited by 1 publication

(2 citation statements)

References 26 publications

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“…Design, define, development, composition, dosage form, pharmacology, indication, administration, dosage, contraindication, strength, assay, content uniformity, quality, undesirable effect, over dosage, specification, container closure system, labelling, miscellaneous changes, packaging information, and more are all aspects of topical spray lifecycle management. 24 Quality control test for topical non-pressurized topical spray are given below in Figure 2.…”

Section: Toxicity Researchmentioning

confidence: 99%

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Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management

Pawar

Jalwal

2021

JPHI

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The medicine was given to the target site with a pressurized topical spray (aerosol pharmaceutical) and a non-pressurized topical spray solution by gently pressing the spray container against the skin and initiating the spray. Formulation components consists of product concentrate (one or more pharmaceutical drugs with relevant excipient) and packaging components (valves, pump, actuator, container). After formulation process development various quality control test like spray pattern, spray content uniformity and geometry, particulate matter, droplet size distribution, microbial limit, net content, pH, osmolarity, weight loss, leachability, viscosity, valves, actuators, diptubes, weight checking, leak test, valve discharge rate, dosage with valves, therapeutic activity, and toxicity studies to check the quality and efficacy. The benefit of Topical Spray Life Cycle Management (post-approval adjustments, 30-day supplements, annual report, Food and Drug Administration inspection and enforcement, cover letter, risk management standard and related information from the International Organization for Standardization) is that it covers the entire lifecycle of a topical spray, from conception through formulation design development to marketing. The product lifecycle management data offers regulatory bodies with a significant financial benefit. Topical non-pressurized sprays have been developed for a variety of applications due to their ease of use, environmental friendliness, low cost, and innovative technology. This review give details about meter dose topical spray of Estradiol, 1% tolnaftate, 2% Miconazole nitrate spray, 0.5% w/w Voriconazole spray, Clotrimazole transdermal apray, Lopinavir meter dose transdermal spray are studied by researcher. This review also enlisted patents and marketed formulation on topical spray from year 2007 to 2020.

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Section: Toxicity Researchmentioning

confidence: 99%

“…SUPAC-IR immediate release advice was produced by the FDA, and it describes the level of changes, feelings, and tests. 24…”

Section: Ubaidulla Et Al 2020 Wo 2006102004mentioning

confidence: 99%

Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management

Pawar

Jalwal

2021

JPHI

View full text Add to dashboard Cite

show abstract

Therapeutic Aerosol: Thermodynamic Method for Managing the Aerosol Particle Size

Cited by 1 publication

References 26 publications

Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management

Non-Pressurized Topical Spray Pharmaceutical-Methodology of Formulation Development and Quality Control Management

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