Therapeutic and Prebiotic Effects of Five Different Native Starches on Dextran Sulfate Sodium‐Induced Mice Model of Colonic Colitis

Xu, Zhenzhen; Liu, Wei; Zhang, Yuhan; Zhang, Di; Qiu, Bin; Wang, Xianshu; Liu, Jie; Liu, Lina

doi:10.1002/mnfr.202000922

Cited by 14 publications

(8 citation statements)

References 45 publications

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“…DSS-induced colitis is a useful experimental model for studying the pathogenesis of inflammatory bowel disease and for testing new therapeutic agents [30,31]. DSS causes intestinal damage and triggers the formation of all stages of classical inflammation [32]. The immune system is also involved in this process, which is of paramount importance in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis due to the development of autoimmunity [33].…”

Section: Discussionmentioning

confidence: 99%

Bacteroidesvesicles promote functional alterations in gut microbiota composition

Shagaleeva,

Kashatnikova,

Kardonsky

et al. 2024

Preprint

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Inflammatory bowel diseases are characterized by chronic intestinal inflammation and alterations of gut microbiota composition. Bacteroides fragilis, which secretes outer membrane vesicles (OMVs) with polysaccharide A (PSA), can moderate inflammatory response and possibly alter microbiota composition. In this research, we created a murine model of chronic DSS-induced intestinal colitis and treated it with Bacteroides fragilis OMVs. We monitored the efficiency of OMVs therapy by determining the disease activity index (DAI) and histological examination (HE) of the intestine before and after vesicles exposure. We also analyzed the microbiota composition using 16S rRNA gene sequencing. Finally, we evaluated the volatile compounds composition in animals' stools by HS-GC/MS to assess the functional activity of the microbiota. As a result, we observed a more effective intestine repair after OMVs treatment according to DAI and HE. The metabolomic study also indicated the microbiota functional activity change, showing a predominance of phenol and pentanoic acid in the control group compared to the group treated with DSS (DSS) and the group treated with OMVs (DSS OMV). We also observed a positive correlation of these metabolites with Saccharibacteria and Hungatei Clostridium in the control group, whereas in the DSS group there was a negative correlation of phenol and pentanoic acid with Lactococcus and Romboutsia. According to metabolome and sequencing data, the microbiota composition of the DSS OMV group was intermediate between the control and DSS groups. It can be concluded that OMVs not only have an anti-inflammatory effect, but also contribute to the recovery of the microbiota composition.

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Section: Discussionmentioning

confidence: 99%

Bacteroidesvesicles promote functional alterations in gut microbiota composition

Shagaleeva,

Kashatnikova,

Kardonsky

et al. 2024

Preprint

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“…A detailed histological scoring criterion with a total range of 0–10 is summarized in Table 2 (Gu et al, 2020). Moreover, Alcian blue staining for mucin distribution in the colon and Periodic acid–Schiff (PAS) staining for goblet cells were performed as described previously (Xu et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory effect of Bifidobacterium animalis subsp. lactis A6 on DSS-induced colitis in mice

Wang

Fan

Zhao

et al. 2022

Journal of Applied Microbiology

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Aims: This study aimed to investigate the protective effect of Bifidobacterium animalis subsp. lactis A6 on dextran sodium sulphate (DSS)-induced colitis in C57BL/6J mice. Methods and Results: Mice were randomly divided into three groups (n = 8 per group). Each group was administered with PBS (Control and DSS group) or B. lactis A6 with a dosage of ~4.0 × 10 9 CFU day −1 (DSS + A6 group) for 21 consecutive days. The DSS and DSS + A6 group mice were ad libitum drinking 2.5% DSS water during day 15-21, while the Control group mice were given normal water. The administration of B. lactis A6 significantly inhibited DSS-induced bodyweight loss and colon shortening (p < 0.001), but showed no significant influence on the spleen enlargement (p > 0.05). The intestinal barrier integrity was improved by reducing colonic damage, recovering mucus layer loss and enhancing tight junction expression including ZO-1, occludin and claudin-1. In addition, B. lactis A6 attenuated the oxidative stress by decreasing MDA and increasing SOD and GSH levels in colon tissues. Moreover, B. lactis A6 suppressed DSS-induced inflammatory responses via downregulating TNF-α, IL-1β and IL-6 levels and upregulating IL-10 level in colon tissues. Conclusion: B. lactis A6 effectively alleviated DSS-induced colitis by maintaining intestinal barrier integrity, reducing oxidative stress and inhibiting inflammatory responses. Significance and Impact of the Study: This study suggests that B. lactis A6 could act as a candidate probiotic for UC treatment.

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“… 243 . Dioscoreae Rhizoma starch could inhibit the pathogenic bacteria of E. coli and Helicobacter hepaticus 244 .…”

Section: Tcms For the Treatment Of Covid-19 Infectionsmentioning

confidence: 99%

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

Ye¹,

Fan²,

Zhao³

et al. 2023

Acta Pharmaceutica Sinica B

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Therapeutic and Prebiotic Effects of Five Different Native Starches on Dextran Sulfate Sodium‐Induced Mice Model of Colonic Colitis

Cited by 14 publications

References 45 publications

Bacteroidesvesicles promote functional alterations in gut microbiota composition

Bacteroidesvesicles promote functional alterations in gut microbiota composition

Anti-inflammatory effect of Bifidobacterium animalis subsp. lactis A6 on DSS-induced colitis in mice

Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

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