Therapeutic application of light emitting diode: Photo-oncomic approach

Oh, Phil-Sun

doi:10.1016/j.jphotobiol.2019.01.003

Cited by 31 publications

(31 citation statements)

References 58 publications

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“…The primary beneficial effects of light-emitting diode (LEd) application on human health were found by the National Aeronautics and Space Administration, with the development of LEds that produce a narrow spectrum of light in a non-coherent manner, delivering the appropriate and required wavelength and intensity (36). Over the past 15 years, LEd technology has continuously improved (36,37). current LEd therapy has the great advantage of high flexibility and adaptability that allows for the treatment of a wide variety of skin conditions exhibiting different biological effects.…”

Section: Introductionmentioning

confidence: 99%

“…The source emits a light whose energy and wavelength emission activate the photosensitizer (38). In addition to the amount of energy, photo-biomodulation also depends on the irradiation time (36). LEd therapy has been approved by the US Food and drug Administration for its use by aestheticians, due to its capacity to increase ATP and transcription factor production, regulate oxidative stress and modulate collagen synthesis (37).…”

Section: Introductionmentioning

confidence: 99%

“…However, the effects induced by the blue light are not yet fully understood. It has been observed that, in the skin and retina, blue light induces suspected mediators of skin aging and age-related macular degeneration (36). The disruption of key cellular processes, such as mitosis and mitochondrial activity as a consequence of blue-light application (43) and the maintenance of dNA integrity (44) have been widely reported.…”

Section: Introductionmentioning

confidence: 99%

“…Previous in vitro and in vivo investigations on skin cancer have revealed that blue LEd induces the apoptosis of cancer cells (52) and a reduction of tumor growth in mice (51). In addition, it has been demonstrated that blue LEd irradiation triggers apoptotic cell death through the mitochondria-mediated intrinsic pathway and shortens the early stage of tumor growth in melanoma cells (36).…”

Section: Introductionmentioning

confidence: 99%

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Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

et al. 2021

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New approaches are being studied for the treatment of skin cancer. It has been reported that light combined with cisplatinum may be effective against skin cancer. In the present study, the effects of specific light radiations and cisplatinum on A431 cutaneous squamous cell carcinoma (cScc) and HacaT non-tumorigenic cell lines were investigated. Both cell lines were exposed to blue and red light sources for 3 days prior to cisplatinum treatment. Viability, apoptosis, cell cycle progression and apoptotic-related protein expression levels were investigated. The present results highlighted that combined treatment with blue light and cisplatinum was more effective in reducing cell viability compared with single treatments. Specifically, an increase in the apoptotic rate was observed when the cells were treated with blue light and cisplatinum, as compared to treatment with blue light or cisplatinum alone. combined treatment with blue light and cisplatinum also caused cell cycle arrest at the S phase. Treatment with cisplatinum following light exposure induced the expression of apoptotic proteins in the A431 and HacaT cell lines, which tended to follow different apoptotic mechanisms. On the whole, these data indicate that blue light combined with cisplatinum may be a promising treatment for cScc.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

et al. 2021

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“…Previous studies have shown that various level of light exposing would cause different biological signi cance [1][2][3]. Recent reports uncovered that LED treatment could meaningfully ameliorate lung in ammation, inhibit human gingival broblast cell proliferation and facilitate Post-surgical recovery and wound healing [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Blue LED causes cell death in human hepatoma by inducing DNA damage

et al. 2020

Preprint

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Phototherapies, including sunlight, infrared, ultraviolet, visible and laser, parts of which present high curative effect, small invasion, and negligible adverse reactions in cancer treatment. Here we aimed to explore the potential therapeutical effects of blue LED in hepatoma cell and decipher the underlying cellular/molecular mechanisms. We demonstrated that the irradiation of blue LED light in hepatoma cell could lead to cell proliferation reduction along with the cell apoptosis increase. Simultaneously, blue LED irradiation also markedly suppressed the migration and invasion ability of hepatoma cells. Sphere formation analysis further revealed the decreased stemness of hepatoma cell under the treatment of blue LED irradiation. In addition, blue LED irradiation significantly promoted the expression of γ-H2AX, a sensitive molecular marker of DNA damage. Collectively, we demonstrated that blue LED irradiation exhibited anti-tumor effects on liver cancer by inducing DNA damage, representing a potential approach for human hepatoma treatment.

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Light‐Responsive Nanoassemblies: Advancing Biomedical Innovation

Sia,

Tey,

Low

2024

Adv Funct Materials

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The integrative use of light and nanoassemblies has made a profound impact in the biomedical field for diagnosis, drug delivery, and phototherapy. Recent advances in the development of light‐responsive nanoassemblies showcase their capabilities in facilitating targeted diagnosis and therapy with minimal invasiveness, shaping the future of personalized medicine. In this work, the fundamental differences between types of light in biomedical applications, and the application of light‐responsive nanoassemblies in diagnosis and therapy are described, their biosafety profile is overviewed and discussed, and the translational challenges and potential clinical outlook of this emerging field are outlined.

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Therapeutic application of light emitting diode: Photo-oncomic approach

Cited by 31 publications

References 58 publications

Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

Blue LED causes cell death in human hepatoma by inducing DNA damage

Light‐Responsive Nanoassemblies: Advancing Biomedical Innovation

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