Therapeutic Application of β-Lactam Antibiotics

Uri, Joseph V.; Actor, Paul

doi:10.1007/978-3-642-68901-7_6

Antibiotics

1983

DOI: 10.1007/978-3-642-68901-7_6

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Therapeutic Application of β-Lactam Antibiotics

Joseph V. Uri¹,

Paul Actor²

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1985

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Cited by 4 publications

(1 citation statement)

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“…Of 261 isolates, 103 (40%) were reported as susceptible to ampicillin by the MMS and resistant by the agar dilution method. Ampicillin is susceptible to penicillin ,-lactamase (25), which has been shown to be present in 90% of 1,982 isolates of Staphylococcus aureus collected over a 4-year period (2). The agar dilution result therefore appears to be more representative of actual ampicillin susceptibility.…”

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confidence: 99%

Evaluation of antibiotic susceptibility testing by agar dilution and the Micro Media system (Fox Panel)

et al. 1985

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The susceptibilities of 350 gram-positive cocci and 638 gram-negative bacilli to various antimicrobial agents were compared by using the Micro-Media system (MMS) (Fox Panel) (Micro-Media Systems, Inc., Potomac, Md.) and a standard agar dilution procedure. Major discrepancies occurred with enterococci, among which 48 of 53 isolates (91%) were found to be resistant to penicillin G by agar dilution and reported as susceptible by the MMS. Other large discrepancies occurred with Staphylococcus aureus and Acinetobacter calcoaceticus subsp. anitratus, among which more than 40% of the isolates were judged to be resistant to ampicillin by agar dilution and susceptible by the MMS. In terms of overall agreement in interpretation of MICs by the two systems, an agreement of greater than 84% was seen for both gram-positive and gram-negative organisms when ampicillin and cephalothin (68 and 78% agreement for gram-positive cocci, respectively) were excluded. These disagreements in MIC interpretations may result in part from the small number of organisms tested per well (4,000 CFU) in the MMS, as compared with 10,000 CFU per test in the agar dilution method.

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Evaluation of antibiotic susceptibility testing by agar dilution and the Micro Media system (Fox Panel)

et al. 1985

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Determination of nafcillin and methicillin by different spectrofluorimetric techniques

Pulgarı́n¹,

Molina²

1994

Talanta

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β-lactam antibiotics: The extended spectrum penicillins

Sahm

Thornsberry

Jones

1985

Antimicrobic Newsletter

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Therapeutic Application of β-Lactam Antibiotics

Cited by 4 publications

References 145 publications

Evaluation of antibiotic susceptibility testing by agar dilution and the Micro Media system (Fox Panel)

Evaluation of antibiotic susceptibility testing by agar dilution and the Micro Media system (Fox Panel)

Determination of nafcillin and methicillin by different spectrofluorimetric techniques

β-lactam antibiotics: The extended spectrum penicillins

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