Therapeutic applications and antibacterial and antifungal activities of Syzygium cumini (L.) Skeels extracts: a systematized literature review focusing on dental applications

Abstract

Medicinal plants are an important source of curative substances for the treatment of diseases. Investigations are focusing particularly on medicinal plants used to treat affections of the oral cavity. Among these species, there is evidence of potential applications of Syzygium cumini to Dentistry. The objective of this systematized literature review was to synthesize the evidence on the antimicrobial activity of this plant, as well cite some as the traditional uses of its extracts for dental purposes. The data indicate that the extracts prepared from different parts of the plant have antibacterial and antifungal effects on different pathogenic microorganisms of the oral microbiota and/or those that can potentially cause oral diseases, demonstrating a promising therapeutic potential for indication and use in Dentistry to prevent and/or treat oral affections.

In vitro and in vivo studies of Syzygium cumini-loaded electrospun PLGA/PMMA/collagen nanofibers for accelerating topical wound healing

“…The use of medicinal plants can be considered a useful alternative for antimicrobial agents. 61 S. cumini extracts demonstrated remarkable pharmacological and antimicrobial activities. 62 The promising therapeutic activity of S. cumini extracts can be explained by the presence of various groups of bioactive metabolites.…”

“…Earlier studies identified secondary metabolites (phytochemical substances), such as flavonoids, phenolic compounds, saponins, tannins, anthocyanins and terpenes, as antimicrobial compounds. 61 For example, an earlier study displayed the therapeutic benefit of S. cumini extract in treating conditions affecting the oral cavity, including dental caries, periodontitis, dental infections, and yeast infection. 63 S. cumini extracts have also demonstrated a variety of biological activities owing to their anti-inflammatory, antioxidant, and anti-carcinogenic effects.…”

“…After that, the protein structure of microbial cells might entirely degrade and leak which could result in cell death. 61 …”