Therapeutic Applications of Nanoemulsion Based Drug Delivery Systems: A Review of Patents in Last Two Decades

Rajpoot, Pooja; Pathak, Kamla; Bali, Vikas

doi:10.2174/187221111795471427

Cited by 46 publications

(16 citation statements)

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“…Dis-advantages [43][44] • The major disadvantage is cost of fabrication of nano emulsion is expensive. Ostwald ripening is the major issue in nano emulsions.…”

Section: Theoriesmentioning

confidence: 99%

Emulsion Micro Emulsion and Nano Emulsion: A Review

Kale¹,

Deore²

2016

SRP

353

166

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Lipid dosage forms are attractive delivery systems for hydrophobic drug molecules. Emulsion is one of the popular system since many decades. Pharmaceutical applications of emulsions widened especially after micro and nano-emulsion emergence. This paper is an attempt to summarise comparative aspects like definition, theories, types, methods of preparations, advantages, disadvantages and methods of analysis of emulsion, micro-emulsion and nano-emulsion.

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“…Dis-advantages [43][44] • The major disadvantage is cost of fabrication of nano emulsion is expensive. Ostwald ripening is the major issue in nano emulsions.…”

Section: Theoriesmentioning

confidence: 99%

Emulsion Micro Emulsion and Nano Emulsion: A Review

Kale¹,

Deore²

2016

SRP

353

166

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“…Nanoemulsions can either be prepared by high-energy dispersion technique or by spontaneous emulsification method such as a self-nanoemulsifying drug delivery system (SNEDDS). Poorly soluble drugs formulated into nanoemulsion have exhibited better in vitro dissolution and in vivo bioavailability (Rajpoot et al, 2011). Therefore, nanoemulsions have emerged as promising drug delivery systems for poorly soluble anti-cancer agents (Qhattal et al, 2011; Ragelle et al, 2012; Yang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion formulations for anti-cancer agent piplartine—Characterization, toxicological, pharmacokinetics and efficacy studies

Fofaria

Qhattal

Liu

et al. 2016

International Journal of Pharmaceutics

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Piplartine (PL) is an alkaloid found in black-pepper and known for its anticancer activity, however, due to poor solubility and lack of proper formulation, its use for oral administration is a challenge. The objective of this study was to formulate PL into nanoemulsion drug delivery system for oral delivery and thereafter evaluate toxicity, pharmacokinetics and therapeutic efficacy. Optimized nanoemulsions were formulated by self-emulsification as well as by homogenization-sonication method. Two nanoemulsions enhanced the solubility of PL with low polydispersity index and high stability. Both PL loaded nanoemulsions exhibited enhanced dissolution, cellular permeability and cytotoxic effects as compared to pure PL. Formulation of PL into nanoemulsions did not obstruct its cellular uptake in cancer cells. Blank or PL loaded nanoemulsions did not exhibited toxicity in mice upon daily oral administration for 60 days. Pharmacokinetics of PL followed a two-compartment model after intravenous administration. PL loaded nanoemulsions showed 1.5-fold increase in oral bioavailability as compared to free PL. Finally, PL loaded nanoemulsions showed marked anti-tumor activity at a dose of 10 mg/kg in melanoma tumor bearing mice. In conclusion, for the first time we have developed a stable nanoemulsion delivery system for oral administration of PL, which enhanced its solubility, oral bioavailability and anti-tumor efficacy.

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“…Nanoemulsion (NE) comprises of two words Nano and Emulsion, meaning emulsion whose particle size is in nanometre range i. e. 10 − 9 m. Miniemulsion was the synonymous term which was used for nanoemulsion [1][2][3] other terms used are ultrafine emulsions [4,5] unstable microemulsions [6] submicrometer emulsions [7,8]. Basic component which are required for fabrication of nanoemulsion are oil, surfactant, co-surfactant, co-solvent and water which result in isotropic, thermodynamically stable, transparent or translucent system [9][10][11] with mean droplet size range of 20-500 nm [12,13]. Due to its small size, it has the ability to cross the biological membrane and hence increasing the therapeutic efficacy of a drug molecule.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

et al. 2017

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Advanced drug delivery system has now gained preference over the conventional drug delivery system. One such research is nanoemulsion which is famous among the researchers because of ease of formation, stability, clarity, increased absorption rate leading to increasing in bioavailability and potential to form a formulation with both lipophilic as well as the hydrophilic drug. Long lasting stability (up to years) and ability to encapsulate both lipophilic and hydrophilic drug has given this colloidal system a valuable position in drug delivery. This article contains information on components required for its fabrication, preparation methods and evaluation parameters along with its application in drug delivery and future aspects of this advanced drug delivery system.

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Therapeutic Applications of Nanoemulsion Based Drug Delivery Systems: A Review of Patents in Last Two Decades

Cited by 46 publications

References 0 publications

Emulsion Micro Emulsion and Nano Emulsion: A Review

Emulsion Micro Emulsion and Nano Emulsion: A Review

Nanoemulsion formulations for anti-cancer agent piplartine—Characterization, toxicological, pharmacokinetics and efficacy studies

Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery

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