Therapeutic approach of natural products that treat osteoporosis by targeting epigenetic modulation

Zhang, Guokai; Liu, Zhenying; Li, Zheyi; Zhang, Bing; Yao, Pengyu; Ye, Qiao

doi:10.3389/fgene.2023.1182363

Cited by 4 publications

(2 citation statements)

References 95 publications

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“…For example, icariin and resveratrol have been widely used in the prevention and treatment of OP ( 110 ). Potential applications for regulating the osteogenic differentiation of BMSCs, preventing bone loss, and promoting bone regeneration have been discovered.…”

Section: Synergistic Effect Of Polyphenols and Gm To Treat Opmentioning

confidence: 99%

The synergistic effects of polyphenols and intestinal microbiota on osteoporosis

Wang,

2023

Front. Immunol.

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Osteoporosis is a common metabolic disease in middle-aged and elderly people. It is characterized by a reduction in bone mass, compromised bone microstructure, heightened bone fragility, and an increased susceptibility to fractures. The dynamic imbalance between osteoblast and osteoclast populations is a decisive factor in the occurrence of osteoporosis. With the increase in the elderly population in society, the incidence of osteoporosis, disability, and mortality have gradually increased. Polyphenols are a fascinating class of compounds that are found in both food and medicine and exhibit a variety of biological activities with significant health benefits. As a component of food, polyphenols not only provide color, flavor, and aroma but also act as potent antioxidants, protecting our cells from oxidative stress and reducing the risk of chronic disease. Moreover, these natural compounds exhibit anti-inflammatory properties, which aid in immune response regulation and potentially alleviate symptoms of diverse ailments. The gut microbiota can degrade polyphenols into more absorbable metabolites, thereby increasing their bioavailability. Polyphenols can also shape the gut microbiota and increase its abundance. Therefore, studying the synergistic effect between gut microbiota and polyphenols may help in the treatment and prevention of osteoporosis. By delving into how gut microbiota can enhance the bioavailability of polyphenols and how polyphenols can shape the gut microbiota and increase its abundance, this review offers valuable information and references for the treatment and prevention of osteoporosis.

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Section: Synergistic Effect Of Polyphenols and Gm To Treat Opmentioning

confidence: 99%

The synergistic effects of polyphenols and intestinal microbiota on osteoporosis

Wang,

2023

Front. Immunol.

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“…In recent years, natural products have emerged as promising candidates for preventing osteoporosis; however, the exact mechanism through which they operate remains unknown, resulting in limiting clinical applications [18]. In response to this challenge, investigating the potential of natural products to counteract bone fragility based on molecular targets could offer potential therapeutic benefits for patients.…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins

Loukas,

Papadourakis,

Panagiotopoulos

et al. 2024

IJMS

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Osteoporosis, characterized by reduced bone density and increased fracture risk, affects over 200 million people worldwide, predominantly older adults and postmenopausal women. The disruption of the balance between bone-forming osteoblasts and bone-resorbing osteoclasts underlies osteoporosis pathophysiology. Standard treatment includes lifestyle modifications, calcium and vitamin D supplementation and specific drugs that either inhibit osteoclasts or stimulate osteoblasts. However, these treatments have limitations, including side effects and compliance issues. Natural products have emerged as potential osteoporosis therapeutics, but their mechanisms of action remain poorly understood. In this study, we investigate the efficacy of natural compounds in modulating molecular targets relevant to osteoporosis, focusing on the Mitogen-Activated Protein Kinase (MAPK) pathway and the gut microbiome’s influence on bone homeostasis. Using an in silico and in vitro methodology, we have identified quercetin as a promising candidate in modulating MAPK activity, offering a potential therapeutic perspective for osteoporosis treatment.

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Alternative Medical Therapy

Jethwa

2023

JOIO

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Therapeutic approach of natural products that treat osteoporosis by targeting epigenetic modulation

Cited by 4 publications

References 95 publications

The synergistic effects of polyphenols and intestinal microbiota on osteoporosis

The synergistic effects of polyphenols and intestinal microbiota on osteoporosis

Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins

Alternative Medical Therapy

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