Therapeutic Aspects of Goldenseal

Asmi, Saftar; Lakshmi, T

doi:10.7897/2230-8407.04909

Cited by 8 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some phenolic compounds present in several wood species showed antimicrobial activity. Taxifolin exhibited antibacterial activity against six known clinical pathogens: Escherichia coli, Listeria sp., Pseudomonas aeruginosa, Bacillus sp., and S. aureus [20]. Oxyresveratrol, the most abundant stilbene in mulberry, was active against the methicillin-resistant S. aureus [21].…”

Section: Introductionmentioning

confidence: 99%

Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts

Smailagić

Ristivojević

Dimkić

et al. 2020

Foods

View full text Add to dashboard Cite

The main focus of this study is to assess radical scavenging and antimicrobial activities of the 11 wood extracts: oak (Quercus petraea (Matt.) Liebl., Q. robur L., and Q. cerris L.), mulberry (Morus alba L.), myrobalan plum (Prunus cerasifera Ehrh.), black locust (Robinia pseudoacacia L.), and wild cherry (Prunus avium L.). High-performance thin-layer chromatography (HPTLC) provided initial phenolic screening and revealed different chemical patterns among investigated wood extracts. To identify individual compounds with radical scavenging activity DPPH-HPTLC, assay was applied. Gallic acid, ferulic and/or caffeic acids were identified as the compounds with the highest contribution of total radical scavenging activity. Principal component analysis was applied on the data set obtained from HPTLC chromatogram to classify samples based on chemical fingerprints: Quercus spp. formed separate clusters from the other wood samples. The wood extracts were evaluated for their antimicrobial activity against eight representative human and opportunistic pathogens. The lowest minimum inhibitory concentration (MIC) was recorded against Staphylococcus aureus for black locust, cherry and mulberry wood extracts. This work provided simple, low-cost and high-throughput screening of phenolic compounds and assessments of the radical scavenging properties of selected individual metabolites from natural matrix that contributed to scavenge free radicals.

show abstract

Section: Introductionmentioning

confidence: 99%

Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts

Smailagić

Ristivojević

Dimkić

et al. 2020

Foods

View full text Add to dashboard Cite

show abstract

“…Additionally, the presence of taxifolin, genistin, and biochanin was previously reported as having an antibacterial activity [70][71][72], reducing bacteria resistance mechanisms and conducting delayed protein synthesis in S. aureus involved in the production of enzymes and nucleic acids required for bacterial growth [17,71,73]. As a result, membrane permeability increases, leading to a decline in bacteria survival.…”

Section: Antifungal and Antibacterial Activitymentioning

confidence: 99%

Genista tridentata Phytochemical Characterization and Biological Activities: A Systematic Review

Laranjeira,

Dias,

Pinto-Ribeiro

2023

Biology

View full text Add to dashboard Cite

Genista tridentata (L.) Willk., known as “prickled broom”, is a Leguminosae (Fabaceae) species native to the Iberian Peninsula, Morocco, Algeria, and Tunisia. It is used in folk medicine as an anti-inflammatory, for gastrointestinal and respiratory disorders, rheumatism, and headaches, to lower blood pressure, against hypercholesterolemia and hyperglycemia. This study aimed to systematically review the literature on the bioactivities and phytochemical profile of Genista tridentata to understand its pharmacological potential. For this, four electronic databases (PubMed, GoogleScholar, Repositórios Cientificos de Acesso Aberto de Portugal (RCCAP), and ScienceDirect) were searched from inception up to 31 December 2022. From a total of 264 potentially eligible studies considered for screening, 34 papers were considered eligible for this systematic review. The sampling included 71 extracts, collected mainly in Portugal. Genista tridentata extracts present a high level of flavonoids and phenolic compounds. The flowers and aerial parts of the plant were the most studied, and aqueous extracts were the most used. The results predict a high potential for the application of Genista tridentata as a new source of natural antioxidants and preservatives for the food industry with subsequent health benefits, such as the production of nutraceuticals. Moreover, the results indicate that the plant can be collected at all seasons of the year, which represents a benefit for the industry.

show abstract

“…Taxifolin has great therapeutic potential for many major inflammatory diseases55, 56 and showed significant ( p < 0.05) reduction in pain when applied topically to painful knee joint, shoulder, calf, hip, lower and upper back 57 . It inhibits Lipopolysaccharide (LPS)-induced tumor necrosis factor-α and interleukin-6 production 58 ; an indication that taxifolin has a significant anti-inflammatory effect.…”

Section: Tamarindus Indica Linnmentioning

confidence: 99%

Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review

Komakech

Kim

Matsabisa

et al. 2019

Integrative Medicine Research

View full text Add to dashboard Cite

Chronic inflammation is one of the causes of a number of non-infectious diseases in the world. Over the years, Tamarindus indica has played fundamental roles in traditional medicine as an anti-inflammatory and analgesic drug. It is a commercialized biocompatible medicinal plant species with a wide range of therapeutic window and with suggested LD50 greater than 5000 mg kg −1 body weight when administered to the Wistar rats. This review examined the anti-inflammatory and analgesic potential and mechanism of various extracts from T. indica pulp, leaves, seeds, stem bark, and roots. The preclinical studies provided strong pharmacological evidence for the anti-inflammatory and analgesic activities of the different parts of T. indica and this may be attributed to the various bioactive compounds in it including alkaloids, flavonoids, tannins, phenols, saponins, and steroids. The anti-inflammatory and analgesic effects of the extracts from the different parts of T. indica may be due to its ability to inhibit a number of biological processes including cyclooxygenase-2 (COX-2) expression, inducible nitric oxide synthase (iNOS), 5-lipoxygenase biosynthesis, and tumor necrosis factor-α. The analgesic activity of T. indica may also be through the activation of the opioidergic mechanism at both the peripheral and central levels. Although further pre-clinical studies still need to be conducted, these results demonstrated that T. indica has potent anti-inflammatory and analgesic activities and hence provides justification for its use in traditional medicine to treat body pain and other inflammatory related diseases including arthritis and offers a basis for future clinical studies and possible drug development.

show abstract

Therapeutic Aspects of Goldenseal

Cited by 8 publications

References 11 publications

Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts

Radical Scavenging and Antimicrobial Properties of Polyphenol Rich Waste Wood Extracts

Genista tridentata Phytochemical Characterization and Biological Activities: A Systematic Review

Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review

Contact Info

Product

Resources

About