Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism

Li, Hao; Sang, Lan; Xia, Xueqi; Zhao, Rui; Wang, Mingyue; Hou, Xiaohong; Xiong, Jiawei; Cao, Tao; Liu, Xiaoquan; Zhang, Jianbin

doi:10.1155/2019/7592124

Cited by 13 publications

(12 citation statements)

References 36 publications

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“…Another study on suspended moxibustion for focal cerebral ischemia/reperfusion injury indicated a greater anti-apoptotic effect of 35minute moxibustion than 15-minute moxibustion [13]. When treating depression-like behavior disorder in rats, prolonged duration of moxibustion under the optimal extent could increase the level of 5-HT [12]. In the treatment of chronic neck pain with the direct moxibustion of small moxa cone, a trend of effect improvement was related to an increase of the amount of moxa cones, when the other dose factors were constant [11].…”

Section: Discussionmentioning

confidence: 99%

“…A variety of factors in uence the therapeutic e cacy of moxibustion, especially moxibustion dose, which includes moxibustion duration, moxibustion frequency, moxibustion amount-size and number of moxa cone [11][12][13][14]. None studies have focused on the dose-effect of moxibustion for CFS up to now, therefore, we designed this trail to investigate the relationship of long-snake-like moxibustion duration and effect in the treatment of CFS by combining subjective scales and objective measurement for assessment.…”

Section: Introductionmentioning

confidence: 99%

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Dose-Effect of Long-Snake-Like Moxibustion for Chronic Fatigue Syndrome: Study Protocol for a Randomized Controlled Trial

Ma¹,

Gong²,

Zheng³

et al. 2021

Preprint

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Background Chronic fatigue syndrome (CFS) is a disease with high incidence rate and great impact on life, but it lacks for specific pharmacological treatment and diagnostic indicators. In the theory of traditional Chinese medicine (TCM), fatigue is the result of Yang deficiency. Long-snake-like moxibustion, as one of a special moxa therapy, has been applied in Yang deficiency patients for thousands of years in China and it is used widely to relieve fatigue symptoms for its strong function of Yang warming. However, the does-effect relationship is unclear in the moxibustion research. Hence, we design this trial to assess the duration-effect of long-snake-like moxibustion through combining measurements of the subjective patient-reported scales with objective medical infrared imaging technology─Thermal Texture Maps (TTM). Methods This is a single-center, randomized controlled trial. Thirty healthy women and sixty female CFS patients will be recruited to receive the first TTM scanning, then CFS patients will be allocated to 60-minute long-snake-like moxibustion (Group A) and 30-minute long-snake-like moxibustion (Group B) equally. These two groups will receive corresponding treatment once a day, three sessions per week every other day for consecutive 4 weeks. The second TTM scanning will be employed for CFS patients after the end of treatment. The primary outcome will be the score improvement of the Fatigue scale-14 (FS-14). Secondary outcomes include the change of the Self-rating depression scale (SDS),the Self-rating anxiety scale (SAS), and the Symptoms Scale of spleen-kidney Yang deficiency. Discussion The trial will provide evidence for the choice of treatment duration for long-snake-like moxibustion in treating CFS. The results will contribute to explore the dose-effect relationship of moxibustion, and optimize the efficacy of moxibustion therapy. Trial registration: Chinese Clinical Trail Registry (No. ChiCTR2000041000), on 16th December, 2020, http://www.chictr.org.cn/showproj.aspx?proj=62488

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dose-Effect of Long-Snake-Like Moxibustion for Chronic Fatigue Syndrome: Study Protocol for a Randomized Controlled Trial

Ma¹,

Gong²,

Zheng³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…As the interventions were not completely the same in the included studies, we divided the study into five subgroups according to the specific intervention methods and performed meta-analysis of the overall efficacy and the efficacy of the subgroups. Also, previous studies have shown that moxibustion works by promoting the absorption of Trp in the brain and transferring the metabolism of Trp to serotonin, which can increase the production of serotonin and exert an antidepressant effect (25). In addition, compared to Western drugs for PSD, the advantages of traditional Chinese medicine (TCM) were safety and low side effects.…”

Section: Relation With Previous Workmentioning

confidence: 99%

“…Several studies have supported the anti-depression effect of moxibustion. Even more importantly, prolonged treatment of moxibustion could promote the brain uptake of L-tryptophan (Trp), shifting the Trp metabolism to 5-hydroxytryptamine (5-HT) (25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Moxibustion for treating patients with post-stroke depression: a systematic review and meta-analysis

Guo¹,

Zhao²,

Li³

et al. 2022

Ann Palliat Med

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Background: To assess the effectiveness and safety of moxibustion for post-stroke depression (PSD). Methods: A search was conducted in the following English and Chinese databases: Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), VIP and Wanfang. The outcomes included Hamilton Depression Rating Scale (HAMD), effective rate, and Modified Edinburgh-Scandinavian Stroke Scale (MESSS) scale. The formulation of search strategy, data extraction, and quality evaluation of involved studies was performed according to Cochrane handbook guidelines. The software RevMan 5.4 and Stata 16 were used for data analysis. The evidence quality of each outcome was evaluated by GRADEpro guideline development tool (GDT).Results: A total of 14 trials with 863 participants were included. A certain risk of bias of unclear or high was detected in the included studies. Compared with the control group, adding moxibustion could change

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“…A systematic review showed that moxibustion could participate in inhibiting oxidative stress and cell apoptosis, adjusting inflammation and Aβ genesis activation of vascular endothelial growth factor, and regulating the metabolic products in the tricarboxylic acid cycle and fatty acid metabolism (Aum et al, 2021 ). In addition, moxibustion could alleviate the depression-like behavior and adjust tryptophan transport and 5-HT generation (Li et al, 2019 ). Ha et al ( 2020 ) found that the effect of moxibustion on the cognition of aging mice is associated with the genes and proteins involved in the APP metabolic pathway.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Mechanism of Moxibustion Treatment on Mild Cognitive Impairment Patients: An fMRI Study Using ALFF

Lai

Zhang

Liang

et al. 2022

Front. Mol. Neurosci.

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BackgroundMild Cognitive Impairment (MCI), as a high risk of Alzheimer’s disease (AD), represents a state of cognitive function between normal aging and dementia. Moxibustion may effectively delay the progression of AD, while there is a lack of studies on the treatments in MCI. This study aimed to evaluate the effect of moxibustion treatment revealed by the amplitude of low-frequency fluctuation (ALFF) in MCI.MethodWe enrolled 30 MCI patients and 30 matched healthy controls (HCs) in this study. We used ALFF to compare the difference between MCI and HCs at baseline and the regulation of spontaneous neural activity in MCI patients by moxibustion. The Mini-Mental State Examination and Montreal Cognitive Assessment scores were used to evaluate cognitive function.ResultsCompared with HCs, the ALFF values significantly decreased in the right temporal poles: middle temporal gyrus (TPOmid), right inferior temporal gyrus, left middle cingulate gyrus, and increased in the left hippocampus, left middle temporal gyrus, right lingual gyrus, and right middle occipital gyrus in MCI patients. After moxibustion treatment, the ALFF values notably increased in the left precuneus, left thalamus, right temporal poles: middle temporal gyrus, right middle frontal gyrus, right inferior temporal gyrus, right putamen, right hippocampus, and right fusiform gyrus, while decreased in the bilateral lingual gyrus in MCI patients. The Mini-Mental State Examination and Montreal Cognitive Assessment scores increased after moxibustion treatment, and the increase in Mini-Mental State Examination score was positively correlated with the increase of ALFF value in the right TPOmid, the right insula, and the left superior temporal gyrus.ConclusionMoxibustion treatment might improve the cognitive function of MCI patients by modulating the brain activities within the default mode network, visual network, and subcortical network with a trend of increased ALFF values and functional asymmetry of the hippocampus. These results indicate that moxibustion holds great potential in the treatment of MCI.

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Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism

Cited by 13 publications

References 36 publications

Dose-Effect of Long-Snake-Like Moxibustion for Chronic Fatigue Syndrome: Study Protocol for a Randomized Controlled Trial

Dose-Effect of Long-Snake-Like Moxibustion for Chronic Fatigue Syndrome: Study Protocol for a Randomized Controlled Trial

Moxibustion for treating patients with post-stroke depression: a systematic review and meta-analysis

Efficacy and Mechanism of Moxibustion Treatment on Mild Cognitive Impairment Patients: An fMRI Study Using ALFF

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