Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters

Wanzeler, Ana Márcia Viana; Júnior, Sérgio Melo Alves; Gomes, Jessica Teixeira; Gouveia, Eduardo Henrique Herbster; Henriques, Higor Yuri Bezerra; Chaves, Rosa Helena; Soares, Bruno Moreira; Salgado, Hugo Leonardo Crisóstomo; Santos, Alberdan Silva; Tuji, Fabrício Mesquita

doi:10.1007/s00784-017-2300-2

Cited by 21 publications

(19 citation statements)

References 26 publications

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“…The intensity of the hemorrhage was determined as follows: clot and intraluminal blood (score 3); mucosal and wall hematomas (score 2); telangiectasia or vessel dilation (score 1); normal (score 0). These criteria were adapted to the stomach and intestine, based on an oral mucositis study 16 .…”

Section: Macroscopic Examination Of the Stomach And Small Intestine (mentioning

confidence: 99%

Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.

Medeiros

Azevedo

Lima

et al. 2018

Rev. Col. Bras. Cir.

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RESUMO Objetivo: examinar os efeitos da sinvastatina na mucosite gástrica e intestinal após o tratamento com 5-fluorouracil (5-FU), determinados pela expressão de citocinas e histologia em ratos. Métodos: ratos pesando 270±15g foram divididos em dois grupos. O grupo 5-FU+salina foi tratado com 5-FU (50mg/kg) mais solução salina a 0,9% por gavagem uma vez ao dia por cinco dias. O grupo 5-FU+sinvastatina foi tratado com 5-FU (50mg/kg), mais sinvastatina (10mg/kg), da mesma forma. Foi feita a eutanásia dos animais no sexto dia. O estômago e o intestino foram fotografados e removidos para exame. Dosagens séricas de TNF-a, IL-1ß, IL-6 e histopatologia (coloração HE) do estômago e intestino foram realizadas. Resultados: o peso corporal diminuiu em ratos no grupo 5-FU+salina. A sinvastatina não inibiu a perda de peso induzida pelo 5-FU. Danos significativos da mucosa no estômago e no jejuno foram observados em ratos que receberam apenas 5-FU. As dosagens séricas de citocinas foram significativamente menores no grupo 5-FU+sinvastatina do que no grupo 5-FU (p<0,05). A sinvastatina causou efeitos protetores significativos contra as lesões da mucosa gástrica e jejunal induzidas por 5-FU. Conclusão: a sinvastatina atenua a mucosite gástrica e intestinal relacionada à terapêutica com 5-FU. Nossos dados encorajam futuros estudos pré-clínicos e clínicos sobre a utilidade das estatinas na prevenção da mucosite gastrointestinal.

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Section: Macroscopic Examination Of the Stomach And Small Intestine (mentioning

confidence: 99%

Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.

Medeiros

Azevedo

Lima

et al. 2018

Rev. Col. Bras. Cir.

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“…The insertion of andiroba oil in the PCL matrix also helps in the high cell viability presented. The oil has anti-inflammatory, antimicrobial, and antiallergic potential effects [ 25 ], is widely used in traditional medicine to treat joint pain and treat muscle and skin injuries [ 65 , 66 ]. The oil still may have antioxidant activities that are important during the inflammatory phase of the healing process [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

“…The andiroba ( Carapa guianensis ) seed oil is widely used in traditional medicine for its pharmacological properties. It is extracted from the seed and has anti-inflammatory, analgesic, antiallergic, antimicrobial, and healing properties, which are derived from its biologically active constituents such as limonoids and triterpenes [ 23 , 24 , 25 ]. Thus, the present study aimed to develop PCL films incorporated with andiroba oil (hybrids) like a scaffold to the wound healing process, using the solvent casting technique.…”

Section: Introductionmentioning

confidence: 99%

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

et al. 2021

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Developing a biomimetic material to wound care is an emerging need for the healing process. Poly (ε-caprolactone) (PCL) is a polymer with the necessary dressing’s requirements often used in medicine. Their surface, physic-chemical and biological properties can be modified by adding bioactive compounds, such as andiroba seed oil (Carapa guianensis). This Amazonian natural plant has medicinal and pharmacological properties. For this purpose, PCL polymeric films incorporated with andiroba oil were investigated. The synthesis of hybrids materials was carried out in the solvent casting method. Thermal properties were evaluated using thermogravimetric analysis (TGA/DTGA) and differential scanning calorimetry (DSC). The solvent type on the surface and hydrophilicity of samples was studied using a scanning electron microscope (SEM). Additionally, contact angle measurements, functional groups analysis, fluid absorption capacity, and cell viability were performed. The results demonstrated the influences of andiroba oil under the morphology and thermal properties of the polymeric matrix; the hydrophilicity of the hybrid film obtained by acetic acid was reduced by 13%; the porosity decreased as the concentration of oil increased, but its higher thermal stability. The L929 cell line’s proliferation was observed in all materials, and it presented nontoxic nature. It was demonstrated the ability of PCL hybrid film as a matrix for cell growth. Then, the materials were proved potential candidates for biomedical applications.

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“…Natural health products (NHP) have also been studied mainly because of their antioxidant, antiinflammatory and healing effects as well as anticancer activity [64,[75][76][77][78]. In this regard, Buccal Bullfrog (Rana catesbeiana Shaw) oil emulsion was successfully used as a mucoadhesive system to treat oral candidiasis [79].…”

Section: Medicinal Herb Derivativesmentioning

confidence: 99%

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

et al. 2021

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Clinical guidelines for oral mucositis (OM) still consist in palliative care. Herein, we summarize cellular and molecular mechanisms of OM ulceration in response to chemical therapies in animal models. We discuss evidenced anti-inflammatory and anti-oxidant drugs which have not been ever used for OM, such as synthetic peptides as well as cell therapy with mesenchymal stem cells; amniotic membranes, mucoadhesive polymers loaded with anti-inflammatory agents and natural or synthetic electrospun. These approaches have been promising to allow the production of drugloaded membranes, scaffolds for cells encapsulation or guided tissue regeneration.

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Therapeutic effect of andiroba oil (Carapa guianensis Aubl.) against oral mucositis: an experimental study in golden Syrian hamsters

Abstract: The use of andiroba in topical form may be associated with reduced intensity of OM. Seek therapeutic alternatives to minimize the pain and suffering that these side effects cause cancer patients is an important scientific step.

Cited by 21 publications

References 26 publications

Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.

Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos.

PCL/Andiroba Oil (Carapa guianensis Aubl.) Hybrid Film for Wound Healing Applications

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

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