Therapeutic effect of mango seed extract in diabetes mellitus.

Abstract

ABSTRACT… Objectives: Diabetes mellitus is very common disease; the oral hypoglycemic drugs are utilized for diabetes. In Asia therapeutic plants are extensively used for cure of widespread variation of illnesses. Objectives: To study the Therapeutic effect of mango seed extract on diabetes Mellitus. Study Design: A prospective study and longitude. Setting: This study was conducted at Jinnah Post graduate Center, Karachi. Period: From June 2016 to June 2017. Material and Methods: Mango seeds were taken out with ethanol and used for study. The antidiabetic action of mango seeds extracts were well-thought-out at 100 and 200 mg/kg b.wt. The antidiabetic effect of mango seeds extracts were matched with tolbutamide 500 mg/ kg b.wt. Result: The ethanolic extract of mango seeds (200 mg/kg) revealed major (p< 0.01) hypoglycemic outcome in fasted diabetic rats, when matched with normal control group. The mango seed extracts were significantly increased insulin level and decreased HbA1c levels at the dose level (100, 200 mg/kg) in alloxone encouraged diabetic rats. Conclusion: The ethanolic extract of mango seeds ensuring important antidabatic outcome compared to aloxone tempted diabetes in albino rats and its stimulating insulin production in pancreas of albino rats.

Mango ginger (Curcuma amada Roxb.) may alleviate the effect of high‐fat diet/streptozotocin‐induced diabetes by activation of the GSK‐3β/Fyn/Nrf2 pathway

“…Sarkar et al ( 2019 ) assumed that the antihyperglycemic effect of MG extract might stem from the stimulation of pancreatic β cells for insulin secretion in streptozotocin (STZ)‐induced diabetic rats. Similarly, Azhar et al ( 2019 ) indicated that the antidiabetic effect of ethanolic mango seed extract was related to insulin production stimulation in the pancreas. However, the molecular action mechanism of MG in type 2 diabetes needs to be clarified.…”

“…Similarly, Azhar et al (2019) indicated that the antidiabetic effect of ethanolic mango seed extract was related to insulin production stimulation in the pancreas. However, the molecular action mechanism of MG in type 2 diabetes needs to be clarified.…”

Phenolic Compounds in Agro-Industrial Waste of Mango Fruit: Impact on Health and Its Prebiotic Effect – a Review

“…Mango seed kernels have also been reported to exert antidiabetic effects (in addition to their anti-tyrosinase, anti-inflammatory, anti-obesity, and hepatoprotective activities) [Abdel-Aty et al, 2018]. For example, a study by Azhar et al [2019] disclosed a hypoglycemic effect in diabetic rats administrated 200 mg/kg of the ethanolic extract of the mango seed. There was an increase in insulin production in the pancreas and a decrease in the level of glycosylated hemoglobin (HbA1c).…”