Therapeutic effect of mesenchymal stem cell on Hashimoto’s thyroiditis in a rat model by modulating Th17/Treg cell balance

Cao, Yongjun; X, Jin; Sun, Yan; Wen, Wang

doi:10.1080/08916934.2019.1697689

Cited by 18 publications

(11 citation statements)

References 27 publications

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“…Diseases. Recent studies demonstrate the remarkable therapeutic effectiveness of MSCs towards several other autoimmune diseases such as type 1 diabetes [77], multiple sclerosis [78], Hashimoto's autoimmune thyroiditis [79], autoimmune hepatitis, primary biliary cirrhosis [80], and vitiligo [81], among others. For example, MSCs have been shown to prevent inflammation and neurodegeneration in animal models of multiple sclerosis (MS).…”

Section: Application In Other Autoimmunementioning

confidence: 99%

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Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases

Wei

Yuan

Wang

et al. 2021

Stem Cells International

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Research on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage formation, adult fracture and tissue repair, and immunomodulatory activities in therapeutic applications. In addition to BM-MSCs, several sources of MSCs have been reported to possess tissue repair and immunoregulatory abilities, making them potential treatment options for many diseases. Therefore, the therapeutic potential of MSCs in various diseases including autoimmune conditions has been explored. In addition to an imbalance of T cell subsets in most patients with autoimmune diseases, they also exhibit complex disease manifestations, overlapping symptoms among diseases, and difficult treatment. MSCs can regulate T cell subsets to restore their immune homeostasis toward disease resolution in autoimmune conditions. This review summarizes the role of MSCs in relieving autoimmune diseases via the regulation of T cell phenotypes.

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Section: Application In Other Autoimmunementioning

confidence: 99%

“…Hashimoto's thyroiditis (HT) is a disease wherein lymphocytes mediate the autoimmune damage and destruction of the thyroid gland. MSCs have been demonstrated to improve HT via reducing the level of thyroid autoantibody partly by regulating Th17/Treg interactions [79].…”

Section: Application In Other Autoimmunementioning

confidence: 99%

Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases

Wei

Yuan

Wang

et al. 2021

Stem Cells International

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“…Использование мультипотентных стромальных клеток для модуляции баланса Treg/Th17 оказалось эффективным в эксперименте, проведенном на крысах: наблюдалось снижение уровня аутоантител, специфичных для щитовидной железы, а также меньшее поражение и сниженная лимфоидная инфильтрация щитовидной железы [81].…”

Section: модуляция соотношения Treg/th17unclassified

The role of regulatory T cells in autoimmune thyroiditis

et al. 2021

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Autoimmune thyroiditis is an organ-specific autoimmune disease caused by the activation of self-reactive CD4+ T cells. Regulatory T (Treg) cells are a population of T cells that play a central role in immunological tolerance by suppressing selfreactive cells. CD4+ Tregs are divided into thymic (tTreg) and peripheral (pTreg). tTregs perform their functions through cytokine-independent mechanisms, pTregs – through IL-10, TGF-β and IL-35. Tregs perform a protective function against AIT. Studies of Treg level in AIT show different results, in most cases Treg level is increased, and their function is impaired. Treg function in AIT is affected by many factors, such as the level of thyroglobulin, vitamin D etc. Apart from the Treg level itself, the Th17/Treg ratio is also crucial in AIT. Activation of Tregs and modification of the Th17/Treg ratio can be used in AIT treatment.

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“…Cellular therapy plays an important role in medicine, especially in haematology [6,7], dermatology [8], orthopaedics [9,10], neurodegenerative diseases [11,12], immunology [13] and ophthalmology, which are highly expected [14,15,16].…”

Section: Introductionmentioning

confidence: 99%

Implementation of experimental cellular (cellular-genetic) therapies on the example of eye diseases

Kapczuk¹,

Rogulska²,

Stangret³

et al. 2020

J Educ Health Sport

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Therapeutic effect of mesenchymal stem cell on Hashimoto’s thyroiditis in a rat model by modulating Th17/Treg cell balance

Cited by 18 publications

References 27 publications

Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases

Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases

The role of regulatory T cells in autoimmune thyroiditis

Implementation of experimental cellular (cellular-genetic) therapies on the example of eye diseases

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