Gold nanoparticles (AuNPs) receive a great deal of attention for biomedical applications due to their unique properties to monitor intracellular delivery of therapeutic agents. Evidently, drug delivery is a compelling field of research due to the need of releasing medicine at specific locations in a controlled manner with a minimum amount of side effects. The present review focuses on the combination of AuNPs with different types of chemotherapeutic agents as potential drug delivery vehicles that can be used in cancer therapy