Therapeutic Effect of Topical Gamma-Linolenic Acid on Refractory Uremic Pruritus

Chen, Yung-Chih; Chiu, Wan–Ting; Wu, Mai Szu

doi:10.1053/j.ajkd.2006.03.082

Cited by 109 publications

(81 citation statements)

References 36 publications

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“…19,20 Other contributing factors comprise xerosis, anemia, high serum aluminum level, increased calcium × phosphate product, hypervitaminosis A, erythropoietin insufficiency, low albumin, low transferrin, elevated ferritin, secondary hyperparathyroidism, dialysis membrane material, inefficient dialysis, systemic inflammation, uremic neuropathy, allergic sensitization, elevated serum histamine level, intradermal mast cell proliferation. 21,22 Most therapies directed at the possible underlying causes of uremic pruritus have demonstrated only limited success. For several times in the past, a new therapeutic option has been introduced to become beneficial, but immediately thereafter inconsistent results appeared.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Panahi¹,

Dashti‐Khavidaki²,

Farnood³

et al. 2016

Adv Pharm Bull

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Panahi¹,

Dashti‐Khavidaki²,

Farnood³

et al. 2016

Adv Pharm Bull

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“…It has been hypothesized that GLA and other essential fatty acids can improve itching by decreasing inflammation. 61 In a randomized controlled, crossover trial of 17 HD or PD patients with refractory pruritus, GLA 2.2% cream significantly improved pruritus compared to placebo over 2 weeks. 61 Similarly in a study of 16 HD patients randomized to oral evening primrose oil, which is GLA-rich, versus linolenic acid, evening primrose oil showed a trend toward improved pruritus compared to linolenic acid after 6 weeks of therapy (0.05<p<0.1).…”

Section: Immunomodulatory Treatmentmentioning

confidence: 99%

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

Shirazian¹,

Aina²,

Park³

et al. 2017

IJNRD

111

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Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked condition in patients with CKD and end-stage renal disease. It affects ~40% of patients with end-stage renal disease and has been associated with poor quality of life, poor sleep, depression, and mortality. Prevalence estimates vary based on the instruments used to diagnose CKD-aP, and standardized diagnostic instruments are sorely needed. Treatment studies have often yielded conflicting results. This is likely related to studies that are limited by small sample size, flawed designs, and nonstandardized diagnostic instruments. Several large well-designed treatment trials have recently been completed and may soon influence CKD-aP management.

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“…For itching intensity, we adapted two scales from those used most widely for quantifying intensity of pain: the 100-mm visual analog scale (VAS) (5-12) and the 11-point numerical rating scale (NRS) (13)(14)(15). The VAS scale already has been used for assessing itching intensity in clinical trials (5)(6)(7)(8)(9)(10)(11)(12). We were interested in comparing patients' ease of use of the NRS with the VAS and in measuring correlations between the two scales.…”

Section: Patient-reported Outcomes Instrument Developmentmentioning

confidence: 99%

A Longitudinal Study of Uremic Pruritus in Hemodialysis Patients

Mathur

Lindberg²,

Germain³

et al. 2010

Clinical Journal of the American Society of Nephrology

264

304

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Background and objectives: Although uremic pruritus (UP) is a highly prevalent complication of chronic kidney disease, it remains poorly characterized. There have been no longitudinal studies of natural history, and no health-related quality of life (HR-QOL) instruments have been developed for UP. The objectives of this study were to describe the natural history of UP, to compare rating scales of itching intensity, and to assess usefulness and validity of HR-QOL instruments for UP.Design, setting, participants, & measurements: The intensity, severity, and effects of pathologic itching on HR-QOL were assessed prospectively in 103 patients with UP on chronic hemodialysis. Outcome measures were obtained at scheduled intervals over 3.5 months.Results: Itching daily or nearly daily was reported by 84% of patients and had been ongoing for >1 year in 59%. In 83%, pruritus involved large, nondermatomal areas with striking bilateral symmetry. Two thirds of the patients were using medications such as antihistamines, steroids, and various emollients without satisfactory relief of itching. Statistically significant associations were found among itching intensity, severity, and HR-QOL measures in domains such as mood, social relations, and sleep. Among patients with moderate-to-severe UP, changes in itching intensity of 20% or greater were associated with significant reductions in HR-QOL measures.Conclusions: This first longitudinal study of UP describes key features of UP and its effect on HR-QOL. The assessment instruments we have developed are easily used, are responsive to changes in UP intensity, and should facilitate clinical evaluation and research to meet the needs of afflicted patients.

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Therapeutic Effect of Topical Gamma-Linolenic Acid on Refractory Uremic Pruritus

Cited by 109 publications

References 36 publications

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges

A Longitudinal Study of Uremic Pruritus in Hemodialysis Patients

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