Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts

He, Hongbing; Ren, Xiaobin; Wang, Xiyue; Shi, Xianzhe; Wang, Xiaolin; Zhong-juan, Ding; Gao, Peng; Xu, Guofeng

doi:10.1016/j.jpba.2011.10.019

Cited by 30 publications

(34 citation statements)

References 29 publications

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“…(2) Yunnan Baiyao, a Chinese herbal medicine, showed an antiarthritic effect against AA by regulating arachidonic acid metabolism in osteoblasts [131]. (3) RvCSd, an oriental herbal mixture, inhibited the production IL-1 β , IL-2, IL-6, TNF- α , and MMP-1 and upregulated the anti-inflammatory cytokines IL-4, IL-10, and tissue inhibitor of metalloproteinase (TIMP)-1 in mice with CIA [132].…”

Section: Herbal Products Used To Treat or Prevent Arthritismentioning

confidence: 99%

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Nanjundaiah

Astry

Moudgil

2013

Evidence-Based Complementary and Alternative Medicine

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints leading to bone and cartilage damage. Untreated inflammatory arthritis can result in severe deformities and disability. The use of anti-inflammatory agents and biologics has been the mainstay of treatment of RA. However, the prolonged use of such agents may lead to severe adverse reactions. In addition, many of these drugs are quite expensive. These limitations have necessitated the search for newer therapeutic agents for RA. Natural plant products offer a promising resource for potential antiarthritic agents. We describe here the cellular and soluble mediators of inflammation-induced bone damage (osteoimmunology) in arthritis. We also elaborate upon various herbal products that possess antiarthritic activity, particularly mentioning the specific target molecules. As the use of natural product supplements by RA patients is increasing, this paper presents timely and useful information about the mechanism of action of promising herbal products that can inhibit the progression of inflammation and bone damage in the course of arthritis.

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Section: Herbal Products Used To Treat or Prevent Arthritismentioning

confidence: 99%

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Nanjundaiah

Astry

Moudgil

2013

Evidence-Based Complementary and Alternative Medicine

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“…The Yunnan Baiyao (YB) is a well known Chinese herbal medicine, firstly introduced in the healthcare market in 1914 [10]. The main compounds of YB are: Radix Notoginseng (Panax pseudoginseng var.…”

Section: Introductionmentioning

confidence: 99%

“…Tseng), Borneolum Synthcticum (Cinnamomum camphora (L.) J. Presl), and Radix Aconiti Kusnezoffii (Aconitum Kusnezoffii Reichb. ); however, the exact composition is confidential, because it is one of the two Class-1 protected traditional Chinese Medicines [10,11]. Nevertheless, some studies tried to characterize the main active principles working in YB, revealing the presence of saponins, terpenoids and steroid glycosides [12,13].…”

Section: Introductionmentioning

confidence: 99%

The Synergic Effect of Terpenoid and Steroidal Saponins Can Improve Bone Healing, by Promoting the Osteogenic Commitment of Adipose Mesenchymal Stem Cells: An In Vitro Study

et al. 2019

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Bone regeneration involves several biological processes that consistently impact the quality of tissue healing. An important step consists of the local recruitment and differentiation of mesenchymal stem cells that migrate in the site to regenerate from bone marrow. Mesenchymal stem cells (MSCs) may be pushed towards osteogenic commitment by specific substances, often naturally present in plants. Yunnan Baiyao (YB) is a Chinese herbal medicine, mainly working through the synergic effect of terpenoid and steroidal saponins. YB is well known for its numerous biomedical effects, including the ability to favor improved bone tissue healing. In our in vitro study, we used adipose mesenchymal stem cells (ADSCs) as a study-model: We selected samples to harvest and isolate ADSCs and investigate their viability; moreover, we performed bone-related gene expression to evaluate the differentiation of MSCs. To confirm this behavior, we analyzed alkaline phosphate activity and calcium deposition, with ADSCs cultured in basal and osteogenic media, with YB at different concentrations in the medium, and at different time-points: 7, 14 and 21 days. Our results indicate that the synergic effect of terpenoid and steroidal saponins slightly favor the late ADSCs differentiation towards the osteoblasts phenotype. In osteogenic committed cells, the treatment with the lower dose of YB promoted the up-regulation of the alkaline phosphatase gene (ALPL) at day seven and 14 (p < 0.01); at day 21, the alkaline phosphatase (ALP) activity showed a slight increase, although in basal condition it maintains low rates. We assume that such molecular synergy can promote the osteogenic commitment of adipose mesenchymal stem cells, thus improving the timing and the quality of bone healing.

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“…Metabonomics makes an impact at several points in the drug mechanism research: multitarget validation, multiple mechanism integration, and comprehensive evaluation [13–15]. The application of metabonomics has dramatically increased in the fields of explanation of medicines mechanism and evaluation of drug efficacy and toxicity [16–18]. Published results indicated that metabonomics presented the potential capability to improve our understanding of TCM like QKL injection [19–22].…”

Section: Introductionmentioning

confidence: 99%

UPLC Q-TOF/MS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia

Gao

Guo

Peng

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Fever is one of the most common clinical symptoms of many diseases. Qingkailing (QKL) injection is widely used in China as a clinical emergency medicine due to its good antipyretic effects. It is a herbal formula which is composed by eight kinds of traditional Chinese medicines (TCM). As a kind of typical multiple constituents and multiple actions of TCM, it is very difficult to elaborate the antipyretic mechanism by conventional pharmacological method. Metabonomics technique provides beneficial tool for this challenge. In this study, an ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS) metabonomics method was developed to explore the changing process of biochemical substances in rats of yeast-induced pyrexia. Partial least squares discriminate analysis (PLS-DA) was used to distinguish the normal control group, the pyrexia model group, and the pyrexia model group treated by QKL injection. The potential biomarkers related to pyrexia were confirmed and identified. MetPA was used to find the possible metabolic pathways. The results indicated that the antipyretic effect of QKL injection on yeast-induced pyrexia rats was performed by repairing the perturbed metabolism of amino acids.

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Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts

Cited by 30 publications

References 29 publications

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

The Synergic Effect of Terpenoid and Steroidal Saponins Can Improve Bone Healing, by Promoting the Osteogenic Commitment of Adipose Mesenchymal Stem Cells: An In Vitro Study

UPLC Q-TOF/MS-Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast-Induced Pyrexia

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