Therapeutic effects of calcium &amp; vitamin D supplementation in women with PCOS

Firouzabadi, Raziah Dehghani; Aflatoonian, Abbas; Modarresi, Seyedehzalfa; Sekhavat, Leila; MohammadTaheri, Somayeh

doi:10.1016/j.ctcp.2012.01.005

Cited by 108 publications

(84 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study conducted by Firouzabadi et al [66] supported these findings. This prospective cohort study of 180 infertile Iranian women again demonstrated no significant association between serum or FF vitamin D levels and CP rates.…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 80%

“…This prospective cohort study of 180 infertile Iranian women again demonstrated no significant association between serum or FF vitamin D levels and CP rates. Overall, [66] also examined embryo quality between deficient, insufficient, and sufficient groups, and found no significant difference (p =0.372). They attributed their null findings to an inadequate sample size.…”

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 98%

“…Only eight of the 34 articles retrieved from PubMed met criteria (Fig. 2) [66][67][68][69][70][71][72][73]. Reference lists of chosen studies and narrative reviews were cross-referenced to find additional studies.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

show abstract

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 80%

Section: Systematic Review On Effects Of Vitamin D On Art Outcomesmentioning

confidence: 98%

See 1 more Smart Citation

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Among these, four had a randomized controlled trial (RCT) design (30,35,36,40), five an open-labeled single-arm design (32,33,37,38,39), and one a case-control study design (31). One RCT carried out by Ardabili et al had a randomized placebo-controlled double-blind study design in which the effect of vitamin D3 supplementation on metabolic parameters and cardiovascular risk factors was evaluated in 50 PCOS women.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

“…Ten intervention trials had been carried out and published until our search in January 2013 (30,31,32,33,34,35,36,37,38,39,40). Among these, four had a randomized controlled trial (RCT) design (30,35,36,40), five an open-labeled single-arm design (32,33,37,38,39), and one a case-control study design (31).…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel

Snackey

Louwers

et al. 2013

European Journal of Endocrinology

115

View full text Add to dashboard Cite

Context: Metabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS. Objective: The aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS. Design and methods: A systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature. Results: We found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women. Conclusions: Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.

show abstract