Therapeutic Effects of Curcuma longa against Rotenone-Induced Gross Motor Skill Deficits in Rats

Madiha, Syeda; Batool, Zehra; Tabassum, Saiqa; Liaquat, Laraib; Sadir, Sadia; Perveen, Tahira; Haider, Saida

doi:10.17582/journal.pjz/2018.50.4.1245.1256

Cited by 10 publications

(4 citation statements)

References 42 publications

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“…The test was done by gently placing the animal on an inclined surface for three minutes and the duration of time the animal remained in one position was recorded in seconds. Cataleptic score was calculated by (latency to move/total time) × 100) [38].…”

Section: Inclined Plane Testmentioning

confidence: 99%

Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity

et al. 2021

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The rotenone-induced animal model of Parkinson’s disease (PD) has been used to investigate the pathogenesis of PD. Oxidative stress is one of the main contributors of neurodegeneration in PD. Flavonoids have the potential to modulate neuronal function and combat various neurodegenerative diseases. The pre- and post-supplementation of quercetin (50 mg/kg, p.o) was done in rats injected with rotenone (1.5 mg/kg, s.c). After the treatment, behavioral activities were monitored for motor activity, depression-like behavior, and cognitive changes. Rats were decapitated after behavioral analysis and the brain samples were dissected out for neurochemical and biochemical estimation. Results showed that supplementation of quercetin significantly (p<0.01) restored rotenone-induced motor and non-motor deficits (depression and cognitive impairments), enhanced antioxidant enzyme activities (p<0.01), and attenuated neurotransmitter alterations (p<0.01). It is suggested that quercetin supplementation improves neurotransmitter levels by mitigating oxidative stress via increasing antioxidant enzyme activity and hence improves motor activity, cognitive functions, and reduces depressive behavior. The results of the present study showed that quercetin pre-supplementation produced more significant results as compared to post-supplementation. These findings show that quercetin can be a potential therapeutic agent to reduce the risk and progression of PD.

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Section: Inclined Plane Testmentioning

confidence: 99%

Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity

et al. 2021

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“…In addition, the glutathione levels of treated rats with curcumin significantly increased with respect to those of rotenone group. 86 The protective effects of C. longa and curcumin on PD were compacted in Table 5 .…”

Section: Methodsmentioning

confidence: 99%

Effects of Medicinal Plants and Flavonoids on Parkinson's Disease, a Review on Basic and Clinical Evidences

2020

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Parkinson’s disease (PD) is a neurodegenerative disorder which is characterized by typical symptoms including gradual progressive muscle rigidity, tremor and loss of motor skills. Although there is no definitive cure for PD, the extract of some medicinal plants and their ingredients have been suggested to relieve its symptoms and to prevent disability in patients. This review is focused on therapeutic effects of some medicinal plants and their ingredients on PD. The findings presented in this review were collected from experimental and clinical studies in databases including PubMed, Web of Science and Google Scholar until the end of May 2019. The keywords "neurotoxicity " or "Parkinson’s disease" or "neuroprotective" and "Medicinal plants" and "Flavonoids" were searched. Based on the results of animal and clinical studies, the extract of medicinal plants and their components which are discussed in this review have neuro-protective effects against PD. These protective properties mainly are mediated through inhibition of dopamine metabolizing enzymes, reduction oxidant markers, increase of antioxidant agents and suppression of neuro-inflammation.

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“…The stride length was estimated in centimeters. It was observed by analyzing the footprint patterns (Madiha et al, 2017).…”

Section: Foot Printing Testmentioning

confidence: 99%

Chamuangone-enriched rice bran oil ameliorates neurodegeneration in haloperidol-induced Parkinsonian rat model via modulation of neuro-inflammatory mediators and suppression of oxidative stress markers

S. Alotaibi,

Saleem,

Ahmad

et al. 2024

Ital. J. Food Sci.

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A natural bioactive compound chamuangone extracted from Thai salad Garcinia cowa leaves exhibited robust medicinal properties, targeting central oxidative stress pathways, and having neuroprotective potential. Chamuangone-enriched rice bran oil (CERBO), with 1.97 mg/mL chamuangone, was obtained through green extraction. The study was designed to evaluate the anti-Parkinson’s activity of CERBO in the haloperidol-induced Parkinsonian rat model. Animals were categorized into six groups as control, disease control and treatment groups. Parkinson’s disease (PD)-like symptoms were induced by administration of haloperidol 1 mg/kg, intraperitoneally; CERBO treatment groups received 2.5, 5, and 7.5 mg/kg orally before the administration of haloperidol for 21 days. Neurobehavioral, biochemical, neurochemical, and histopathological studies along with gene expression analysis were performed at the completion of the study. CERBO markedly recover the motor and non-motor PD-like symptoms in treatment groups dose-dependently. The levels of antioxidant enzymes, such as catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase, increased, while malondialdehyde levels decreased dose-dependently in CERBO-treated groups. CERBO dose-dependent elevations were observed in neurotransmitters (dopamine, serotonin, and noradrenaline). PD-associated specific biomarker (α-synuclein) decreased dose-dependently with downregulation in messenger RNA expression of neuro-inflammatory mediators (interleukin α, interleukin 1β, and tumor necrosis factor-α). Histopathological studies revealed recovery in neuronal loss, formation of Lewy’s bodies, and neurofibrillary tangles in the treatment groups. It was concluded from the data that CERBO possessed good anti-Parkinson’s activity and could be a novel, safe, and effective remedy for the treatment of PD.

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Therapeutic Effects of Curcuma longa against Rotenone-Induced Gross Motor Skill Deficits in Rats

Abstract: Authors' Contribution SM and SH designed the research. LL, SS and SM conducted aboratory work. ZB and ST performed statistical analyses. LL, SS, SM and TP wrote the article. SH supervised the research.

Cited by 10 publications

References 42 publications

Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity

Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity

Effects of Medicinal Plants and Flavonoids on Parkinson's Disease, a Review on Basic and Clinical Evidences

Chamuangone-enriched rice bran oil ameliorates neurodegeneration in haloperidol-induced Parkinsonian rat model via modulation of neuro-inflammatory mediators and suppression of oxidative stress markers

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