Therapeutic effects of growth hormone combined with low‐dose stanozolol on growth velocity and final height of girls with Turner syndrome

Xiong, Hui; Chen, Hongshan; Du, Mingmei; Li, Yanhong; Ma, Haitian; Su, Zhe; Chen, Qiuli

doi:10.1111/cen.12785

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…To increase adult height, nonaromatizable androgens such as oxandrolone and stanozolol can be used [ 35 - 37 ]. If a patient is severely short for her age, very short a dult height is expected, or growth rate is modest despite GH use, additive treatment with the anabolic steroid oxandrolone (0.03−0.05 mg/kg/day, from the age of 10 years or older) can be considered.…”

Section: Therapeutic Considerations: Focus On Hormone Replacement Thementioning

confidence: 99%

Diagnostic and therapeutic considerations in Turner syndrome

Yang¹

2017

Ann Pediatr Endocrinol Metab

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Newly developed genetic techniques can reveal mosaicism in individuals diagnosed with monosomy X. Noninvasive prenatal diagnosis using maternal blood can detect most fetuses with X chromosome abnormalities. Low-dose and ultralow-dose estrogen replacement therapy can achieve a more physiological endocrine milieu. However, many complicated and controversial issues with such treatment remain. Therefore, lifetime observation, long-term studies of health problems, and optimal therapeutic plans are needed for women with Turner syndrome. In this review, we discuss several diagnostic trials using recently developed genetic techniques and studies of physiological hormone replacement treatment over the last 5 years.

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Section: Therapeutic Considerations: Focus On Hormone Replacement Thementioning

confidence: 99%

Diagnostic and therapeutic considerations in Turner syndrome

Yang¹

2017

Ann Pediatr Endocrinol Metab

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“…Stanozolol (ST), a non-aromatizable androgen that has a high anabolic to androgenic ratio has been used to stimulate growth and final adult height of patients with other disease such as Turner syndrome (TS) ( 17 ). ST also used to treat some serious disorders like aplastic anemia and hereditary angioedema.…”

Section: Introductionmentioning

confidence: 99%

GnRHa/Stanozolol Combined Therapy Maintains Normal Bone Growth in Central Precocious Puberty

Zhu

Long

et al. 2021

Front. Endocrinol.

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BackgroundGonadotropin-releasing hormone agonist (GnRHa) is the gold standard in the treatment of Central Precocious Puberty (CPP) with progressive puberty and accelerative growth. However, GnRHa treatment is reported to result in growth deceleration and prevents growth plate development which leads to a reduction in height velocity. Stanozolol (ST) has been used to stimulate growth in patients with delayed growth and puberty, nevertheless, the effects and mechanisms of ST on CPP with GnRHa treatment are currently unclear.Methods and ResultsIn the current study, we recorded the following vital observations that provided insights into ST induced chondrogenic differentiation and the maintenance of normal growth plate development: (1) ST efficiently prevented growth deceleration and maintained normal growth plate development in rats undergoing GnRHa treatment; (2) ST suppressed the inhibitory effect of GnRHa to promote chondrogenic differentiation; (3) ST induced chondrogenic differentiation through the activation of the JNK/c-Jun/Sox9 signaling pathway; (4) ST promoted chondrogenic differentiation and growth plate development through the JNK/Sox9 signaling pathway in vivo.ConclusionsST mitigated the inhibitory effects of GnRHa and promoted growth plate development in rats. ST induced the differentiation of chondrocytes and maintained normal growth plate development through the activation of JNK/c-Jun/Sox9 signaling. These novel findings indicated that ST could be a potential agent for maintaining normal bone growth in cases of CPP undergoing GnRHa treatment.

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“…However, the recent literature shows that for this population, achieving a mature uterine morphology is not a guarantee, even with HRT [5]. Moreover, some studies have investigated Chinese girls with TS [6], but to our knowledge, no existing study has examined Chinese girls with TS who were undergoing HRT. To investigate the pubertal development mode of girls with TS, ensure the integrity of the TS puberty database and describe the characteristics of optimal HRT, we conducted a longitudinal study that retrospectively examined 71 Chinese girls with TS who were undergoing HRT.…”

Section: Introductionmentioning

confidence: 99%

The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

Guo

Zhang

et al. 2019

BMC Endocr Disord

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Background Further knowledge about the pubertal development mode of girls with Turner syndrome (TS) who have undergone hormone replacement therapy (HRT) is beneficial to the proposal of an optimal HRT regimen. This study examined the pubertal development mode of girls with TS who underwent HRT and evaluated the characteristics of optimal sex induction therapy in girls with TS. Method We conducted a retrospective, longitudinal study over the past two decades at The First Affiliated Hospital, Sun Yat-sen University. Patients Seventy-one patients with TS and two groups of normal Chinese girls. Results The total investigation time was 3.00 (2.00, 4.66) years. The interval of each stage was significantly longer ( P < 0.001) in the girls with TS than that in the normal Chinese girls, except for B2–3 ( P = 0.011). The uterine volumes of the girls with TS in stages B2 and 3 were greater than those of the control group ( P = 0.046), whereas the uterine volume of the control group was inversely greater than that of the TS group among those who reached stages B4 and 5 ( P = 0.034). During HRT, the uterine volume grew significantly from all previous stages except for breast stage 5 (B 3 vs.2 : Z = − 2.031; P = 0.042; B 4 vs. 3 : Z = − 2.273; P = 0.023; B 5 vs. 4 : Z = − 1.368; P = 0.171). The paired data of 27 girls with TS showed that the uterine volume (17.93 ± 9.31 ml vs. 13.75 ± 6.67 ml) and width (2.54 ± 0.66 cm vs. 2.22 ± 0.36 cm) increased significantly during artificial cycles compared with before artificial cycles (t = − 2.79 and − 2.51, P = 0.01 and 0.018). Conclusion HRT led to normal breast development in girls with TS; half of the girls with TS in our study reached Tanner stage B5, although the uterus ultimately developed suboptimally. The girls’ breasts and uteruses grew quickly at the beginning of HRT (stages B2–4). An optimal HRT regimen for girls with TS may specifically focus on Tanner stages B2–4 and artificial cycles.

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Therapeutic effects of growth hormone combined with low‐dose stanozolol on growth velocity and final height of girls with Turner syndrome

Abstract: In girls with TS, 9-12 years of age, rhGH combined with low-dose stanozolol may effectively increase growth. At least a 2-year course of this treatment may effectively improve FAH with proper delay of oestrogen-induced development.

Cited by 5 publications

References 26 publications

Diagnostic and therapeutic considerations in Turner syndrome

Diagnostic and therapeutic considerations in Turner syndrome

GnRHa/Stanozolol Combined Therapy Maintains Normal Bone Growth in Central Precocious Puberty

The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

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