Therapeutic effects of human amniotic epithelial stem cells in Niemann–Pick type C1 mice

Hong, Saetbyul; Seo, Min–Soo; Park, Sang‐Bum; Seo, Yoojin; Kim, Jong Sung; Kang, Kyungsik

doi:10.3109/14653249.2012.663485

Cited by 20 publications

(14 citation statements)

References 23 publications

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“…Transplantation of 5 × 10 5 hAECs cells every other week via the tail vein prolonged the survival of mice with experimentally induced Niemaoh-Pick disease [85]. Loss of body weight, organ damage, cholesterol deposition, and the relative weight of the liver were all reduced, indicating that hAECs may have a role in the treatment of fatal genetic diseases, including the metabolic liver disease.…”

Section: Genetic Liver Diseasesmentioning

confidence: 93%

Therapeutic Strategies of Stem Cell Transplantation for Liver Cirrhosis

Fan¹

2017

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Liver transplantation is widely regarded as the most effective therapy for end-stage liver diseases. However, stem cell-based therapy is being developed as a promising strategy which offers a number of benefits as it is minimally invasive and associated with low immunogenicity and low cost. This paper will review the major clinical issues surrounding the use of stem cell therapy for managing cirrhosis, such as discussing the selection of appropriate subtypes of bone marrow stem cells and the need for pre-differentiation into hepatocyte-like cells prior to transplantation, and providing an overview of the methods to improve cell viability and to prevent the exacerbation of cirrhosis. The role of human umbilical cord blood stem cells and amniotic epithelial cells for the treatment of liver disease will be also introduced.

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Section: Genetic Liver Diseasesmentioning

confidence: 93%

Therapeutic Strategies of Stem Cell Transplantation for Liver Cirrhosis

Fan¹

2017

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“…The human AESCs and human UCB-MSCs were primary cultured as previously described [37, 38]. AESCs show a positive expression pattern with CD4, −24, -29, -49b, -73, -90 and -105, as well as a negative expression pattern with CD14, -31, -34 and -45.…”

Section: Methodsmentioning

confidence: 99%

Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203

et al. 2016

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Stem cell-based photoreceptor differentiation strategies have been the recent focus of therapies for retinal degenerative diseases. Previous studies utilized embryonic stem (ES) cells and neural retina differentiation cocktails, including DKK1 and Noggin. Here, we show a novel microRNA-mediated strategy of retina differentiation from somatic stem cells, which are potential allogeneic cell sources. Human amniotic epithelial stem cells (AESCs) and umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) treated with a retina differentiation cocktail induced gene expressions of retina development-relevant genes. Furthermore, microRNA-203 (miR-203) is abundantly expressed in human AESCs and human UCB-MSCs. This miR-203 is predicted to target multiple retina development-relevant genes, particularly DKK1, CRX, RORβ, NEUROD1, NRL and THRB. The inhibition of miR-203 induced a retina differentiation of AESCs and UCB-MSCs. Moreover, successive treatments of anti-miR-203 led to the expression of both mature photoreceptor (PR) markers, rhodopsin and opsin. In addition, we determined that CRX, NRL and DKK1 are direct targets of miR-203 using a luciferase assay. Thus, the work presented here suggests that somatic stem cells can potentially differentiate into neural retina cell types when treated with anti-miR-203. They may prove to be a source of both PR subtypes for future allogeneic stem cell-based therapies of non-regenerative retina diseases.

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“…Similarly, AECs can reduce brain edema and motor deficit in intracerebral hemorrhagic rats (Dong et al, 2010). The transplantation of human AECs mitigates many age-associated phenotypes in the Niemann-Pick type C1 mice including extension of life span, reduction in rapid weight loss, and alleviation of tissue damage (Hong et al, 2012). …”

Section: Aecs Transplantation To Improve Organ Functionsmentioning

confidence: 99%

Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases?

Germanio

Bernier

Cabo

et al. 2016

Front. Cell Dev. Biol.

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The number of elderly people is growing at an unprecedented rate and this increase of the aging population is expected to have a direct impact on the incidence of age-related diseases and healthcare-associated costs. Thus, it is imperative that new tools are developed to fight and slow age-related diseases. Regenerative medicine is a promising strategy for the maintenance of health and function late in life; however, stem cell-based therapies face several challenges including rejection and tumor transformation. As an alternative, the placenta offers an extraordinary source of fetal stem cells, including the amniotic epithelial cells (AECs), which retain some of the characteristics of embryonic stem cells, but show low immunogenicity, together with immunomodulatory and anti-inflammatory activities. Because of these characteristics, AECs have been widely utilized in regenerative medicine. This perspective highlights different mechanisms triggered by transplanted AECs that could be potentially useful for anti-aging therapies, which include: Graft and differentiation for tissue regeneration in age-related settings, anti-inflammatory behavior to combat “inflammaging,” anti-tumor activity, direct lifespan and healthspan extension properties, and possibly rejuvenation in a manner reminiscent of heterochronic parabiosis. Here, we critically discuss benefits and limitation of AECs-based therapies in age-related diseases.

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Therapeutic effects of human amniotic epithelial stem cells in Niemann–Pick type C1 mice

Cited by 20 publications

References 23 publications

Therapeutic Strategies of Stem Cell Transplantation for Liver Cirrhosis

Therapeutic Strategies of Stem Cell Transplantation for Liver Cirrhosis

Direct cell fate conversion of human somatic stem cells into cone and rod photoreceptor-like cells by inhibition of microRNA-203

Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases?

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