Therapeutic effects of omoconazole nitrate on experimental tinea pedis, an intractable dermatophytosis, in guinea-pigs

Abstract

The therapeutic efficacy of omoconazole nitrate was investigated in an experimental tinea pedis model produced by topical inoculation with Trichophyton mentagrophytes in guinea-pigs, which is pathologically similar to naturally infected tinea pedis in humans. Treatment with omoconazole nitrate cream was started on week 2 postinfection and continued for 3 or 4 weeks. Once-a-day application of 1% omoconazole nitrate to the site of infection exhibited an excellent therapeutic efficacy, and was superior to 1% bifonazole cream in culture result. This result suggests that omoconazole nitrate has a potential usefulness for the treatment of tinea pedis in humans.

Animal Model of Dermatophytosis

“…Antifungal efficacy in the tinea pedis animal model was evaluated with different antifungals, such as butenafine [73, 78, 79], latoconazole [25, 80], naftifine [78], tolnaftate [25, 76, 78, 80], clotrimazole [25, 76, 78, 80], bifonazole [25, 74, 78–80], terbinafine [67, 71–73], griseofulvin [67], lanoconazole [70–72, 81], omoconazole [74], miconazole [75], NND-502 (luliconazole) [72, 77], a combination drug of 0.2% pyrrolnitrin and 0.4% clotrimazole [75], variotin [76], phenyl-11-iodo-10-undecynoate [76], siccanin [76], KP-103 [81], and neticonazole [81]. Ohmi et al compared antifungal efficacy with two animal models, tinea corporis and tinea pedis, using the same antifungal agents [80].…”

Development of an Animal Model of Onychomycosis in Guinea Pigs

“…Trichophyton mentagrophytes TIMM 2789, a zoophilic dermatophyte 11) , maintained at Teikyo University Institute of Medical Mycology (Tokyo, Japan), was used in this study. Freeze-dried T. mentagrophytes was subcultured on Sabouraud dextrose agar (Becton, Dickinson and Company) at 28°C for 2 weeks to produce microconidia.…”