Therapeutic Effects of Phytochemicals of Brassicaceae for Management of Obesity

Kuerban, Abudukadeer; Yaghmoor, Soonham; Almulaiky, Yaaser Q.; Mohamed, Youssri; Razvi, Syed Shoeb; Al‐Hasan, Muath; Moselhy, Said S; Al-Ghafari, A; Alsufiani, Hadeel; Kumosani, Taha; Al-Malki, Abdulrahman L.

doi:10.9734/jpri/2017/37617

Cited by 14 publications

(8 citation statements)

References 35 publications

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“…It is likely that kale phytochemical metabolic products impact the inflammation mechanisms. Like other cruciferous vegetables, the phytochemical composition of kale includes sulfur-containing indolic glucosinolates, aliphatic glucosinolates, polyphenols and carotenoid groups [ 3 , 4 , 5 , 6 ] that impact inflammatory mechanisms. All these may individually impact microbiota composition in ways that are yet unknown.…”

Section: Discussionmentioning

confidence: 99%

“…It has become an important crop in the southern US as a result of its suitability to year-round growing conditions [ 1 ]. Similar to other cruciferous vegetables, phytochemicals in kale include sulfur-containing indolic glucosinolates and aliphatic glucosinolates, polyphenols like the flavonoid glycosides of quercetin, kaempferol and isorhamnetin and carotenoid groups [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Kale Attenuates Inflammation and Modulates Gut Microbial Composition and Function in C57BL/6J Mice with Diet-Induced Obesity

et al. 2021

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Kale (Brassica oleracea var. acephala) is a vegetable common in most cultures but is less studied as a functional food compared to other cruciferous vegetables, such as broccoli. We investigated the effect of supplementing a high-fat diet (HFD) with kale (HFKV) in C57BL/6J mice. We particularly explored its role in metabolic parameters, gut bacterial composition and diversity using 16S rRNA sequencing, systematically compared changes under each phylum and predicted the functional potential of the altered bacterial community using PICRUSt2. Like other cruciferous vegetables, kale attenuated HFD-induced inflammation. In addition, kale modulated HFD-induced changes in cecal microbiota composition. The HFD lowered bacterial diversity, increased the Firmicutes: Bacteroidetes (F/B) ratio and altered composition. Specifically, it lowered Actinobacteria and Bacteroidetes (Bacteroidia, Rikenellaceae and Prevotellaceae) but increased Firmicutes (mainly class Bacilli). Kale supplementation lowered the F/B ratio, increased both alpha and beta diversity and reduced class Bacilli and Erysipelotrichi but had no effect on Clostridia. Within Actinobacteria, HFKV particularly increased Coriobacteriales/Coriobacteriaceae about four-fold compared to the HFD (p < 0.05). Among Bacteroidia, HFKV increased the species Bacteroides thetaiotaomicron by over two-fold (p = 0.05) compared to the HFD. This species produces plant polysaccharide digesting enzymes. Compared to the HFD, kale supplementation enhanced several bacterial metabolic functions, including glycan degradation, thiamine metabolism and xenobiotic metabolism. Our findings provide evidence that kale is a functional food that modulates the microbiota and changes in inflammation phenotype.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kale Attenuates Inflammation and Modulates Gut Microbial Composition and Function in C57BL/6J Mice with Diet-Induced Obesity

et al. 2021

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“…acephala has been reported to use for treating diabetes mellitus, rheumatism, bone weakness, ophthalmologic problems, hepatic diseases, anemia, obesity etc. (Lemos et al 2011;Gonçalves et al 2012, Kuerban et al 2017.…”

Section: Contemporary and Traditional Usementioning

confidence: 99%

Kale (Brassica oleracea var. acephala) as a superfood: Review of the scientific evidence behind the statement

Šamec

Urlić

Salopek‐Sondi

2018

Critical Reviews in Food Science and Nutrition

187

106

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Kale (Brassica oleracea var. acephala) is a cruciferous vegetable, characterized by leaves along the stem, which, in recent years, have gained a great popularity as a ´superfood´. Consequently, in a popular culture it is listed in many ´lists of the healthiest vegetables´. Without the doubt, a scientific evidences support the fact that cruciferous vegetables included in human diet can positively affect health and well-being, but remains unclear why kale is declared superior in comparison with other cruciferous. It is questionable if this statement about kale is triggered by scientific evidence or by some other factors. Our review aims to bring an overview of kale's botanical characteristics, agronomic requirements, contemporary and traditional use, macronutrient and phytochemical content and biological activity, in order to point out the reasons for tremendous kale popularity.

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“…The protective effect of natural compounds may be attributed to the presence of numerous phytochemicals such as resveratrol, quercetin, rutin, catechin, myricetin, kaempferol, and Epigallocatechin gallate (EGCG). EGCG has been reported to modulate multiple key elements in signal transduction pathways affecting cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis in CRC (Araujo et al, 2011;Kuerban et al, 2017;Soengas Fernández et al, 2011;Moselhy et al, 2018). Initial studies have revealed that these compounds are able to affect cell proliferation, cell cycle regulation, and usually participate in multiple signaling pathways which are often disrupted in tumor initiation, proliferation and propagation (Kotecha et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer

et al. 2023

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Colorectal cancer (CRC) is one of the most common cancers leading to comorbidities and mortalities globally. The rational of current study was to evaluate the combined epigallocatechin gallate and quercetin as a potent antitumor agent as commentary agent for therapeutic protocol. The present study investigated the effect of epigallocatechin Gallate (EGCG) (150mg) and quercetin (200mg) at different proportions on proliferation and induction of apoptosis in human colon cancer cells (HCT-116). Cell growth, colonogenic, Annexin V in addition cell cycle were detected in response to phytomolecules. Data obtained showed that, the colony formation was inhibited significantly in CRC starting from the lowest concentration tested of 10 µg/mL resulting in no colonies as visualized by a phase-contrast microscope. Data showed a significant elevation in the annexin V at 100 µg/mL EGCG(25.85%) and 150 µg/mL quercetin (48.35%). Moreover, cell cycle analysis showed that this combination caused cell cycle arrest at the G1 phase at concentration of 100 µg/mL (72.7%) and 150 µg/mL (75.25%). The combined effect of epigallocatechin Gallate and quercetin exert antiproliferative activity against CRC, it is promising in alternative conventional chemotherapeutic agent.

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Therapeutic Effects of Phytochemicals of Brassicaceae for Management of Obesity

Cited by 14 publications

References 35 publications

Kale Attenuates Inflammation and Modulates Gut Microbial Composition and Function in C57BL/6J Mice with Diet-Induced Obesity

Kale Attenuates Inflammation and Modulates Gut Microbial Composition and Function in C57BL/6J Mice with Diet-Induced Obesity

Kale (Brassica oleracea var. acephala) as a superfood: Review of the scientific evidence behind the statement

Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer

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