Therapeutic efficacy of adjunctive photodynamic therapy in the treatment of denture stomatitis

Al-Ghamdi, Abdul Rahman Saeed; Khanam, Khudija; Qamar, Zeeshan; Abdul, Nishath Sayed; Reddy, Naveen; Vempalli, Shweta; Noushad, Mohammed; Alqahtani, Waleed M.S.

doi:10.1016/j.pdpdt.2023.103326

Cited by 5 publications

(18 citation statements)

References 51 publications

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“…The number of subjects in each included study ranged between 22 and 65. Five studies [14,15,22,26,35] were conducted in Brazil, four [23,25,27,31] in Saudi Arabia, one [24] in India, and one in Iran [34]. Only eight studies [14,15,23,[25][26][27]31] reported gender of the participants where the majority were females.…”

Section: General Characteristicsmentioning

confidence: 99%

“…Five studies [14,15,22,26,35] were conducted in Brazil, four [23,25,27,31] in Saudi Arabia, one [24] in India, and one in Iran [34]. Only eight studies [14,15,23,[25][26][27]31] reported gender of the participants where the majority were females. The follow-up period ranged from 30 to 90 days.…”

Section: General Characteristicsmentioning

confidence: 99%

“…All included studies used topical antifungal therapy as a comparator group. Of these, seven studies [14,22,23,25,26,34,35] used topical Nystatin oral suspension 100,000UL/mL (four times/day for 15 days), three studies [15,27,31] used topical miconazol 2% gel, and one study [24] used Clotrimazole paint (four times/day for 15 days).…”

Section: General Characteristicsmentioning

confidence: 99%

“…Number of PDT sessions ranged from 2-6 sessions (Table 3). Six studies [15,23,24,27,34,35] used diode laser whereas ve studies [14,22,25,26,31] used light emitting diode (LED). The wavelengths and the power density of laser ranged from 455 nm to 940 nm and 40 to 240 mW cm 2 , respectively (Table 2).…”

Section: Photosensitizers and Laser Related Parametersmentioning

confidence: 99%

“…It is worth mentioning, however, that the aforementioned reviews included only very limited number of studies (3-5 studies) and failed to include all potentially eligible studies, and thus the results might be inconclusive. Additionally, since then more recent relevant clinical trials assessing the e cacy of PDT in DS have been published [22,27,31], again with interesting results.…”

Section: Introductionmentioning

confidence: 98%

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Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: An updated systematic review and meta-analysis

Al-Maweri,

Alhajj,

Anweigi

et al. 2023

Preprint

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Background: Photodynamic therapy (PDT) has recently been proposed as a promising therapeutic option for Denture Stomatitis (DS). This updated systematic review and meta-analysis investigated the current evidence regarding the efficacy of PDT for DS. Materials and methods: PubMed, Scopus, Web of Science, Google Scholar, and ProQuest were searched up to June 7, 2023. All relevant clinical trials were included. RevMan software was used for meta-analysis. Results: Elven randomized clinical trials (460 DS patients) were included. Eight studies assessed the efficacy of PDT vs. topical antifungal, while three studies assessed the adjunctive use of PDT (PDT+antifungal therapy) vs. topical antifungal therapy alone. The results revealed insignificant less efficacy of PDT in comparison to topical antifungal therapy on candida colonization at 15 days (MD: 0.95, 95% CI: -0.28, 2.19, p = 0.13), but comparable results at the end of follow-up (MD: -0.17, 95% CI: -1.33, 0.98, p = 0.77). The pooled two studies revealed relative better efficacy of adjunctive use of PDT with antifungal therapy on candida colonization compared to antifungal therapy alone at 15 days (MD: -6.67, 95% CI: -15.15, 1.82, p = 0.12), and at the end of follow-up (MD: -7.14, 95% CI: -19.78, 5.50, p = 0.27). Additionally, the results revealed comparable efficacy of PDT and topical antifungal therapy in improvement of the clinical signs. Conclusions: PDT might be a viable option for DS as an adjunct or an alternative to the topical antifungal medications. Further studies with large sample sizes and standardized PDT parameters are warranted.

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Section: General Characteristicsmentioning

confidence: 99%

Section: General Characteristicsmentioning

confidence: 99%

Section: General Characteristicsmentioning

confidence: 99%

Section: Photosensitizers and Laser Related Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: An updated systematic review and meta-analysis

Al-Maweri,

Alhajj,

Anweigi

et al. 2023

Preprint

Self Cite

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Efficacy of adjunct photodynamic therapy on Candida growth and oral health quality of life in denture stomatitis patients with type 2 diabetes mellitus wearing implant-retained overdentures: A randomized clinical study

Al-Aali,

Alqahtani,

AlZaid

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis

Al-Maweri,

Alhajj,

Anweigi

et al. 2024

BMC Oral Health

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Background Photodynamic therapy (PDT) has been recently proposed as a promising alternative therapy for Denture Stomatitis (DS). The present systematic review and meta-analysis investigated the current available evidence regarding the efficacy of PDT in the management of DS. Materials and methods PubMed, Scopus, Web of Science, Google Scholar, and ProQuest were searched up to June 7, 2023. All relevant clinical trials were included. RevMan software was used for the statistical analyses. Results Elven randomized clinical trials (460 DS patients) were included. Eight studies assessed the efficacy of PDT vs. topical antifungal therapy, while three studies assessed the adjunctive use of PDT (PDT + antifungal therapy) vs. topical antifungal therapy alone. The results revealed comparable efficacy of PDT and conventional antifungal therapy on candida colonization at 15 days (MD: 0.95, 95% CI: -0.28, 2.19, p = 0.13) and at the end of follow-up (MD: -0.17, 95% CI: -1.33, 0.98, p = 0.77). The pooled two studies revealed relatively better efficacy of adjunctive use of PDT with antifungal therapy on candida colonization compared to antifungal therapy alone at 15 days (MD: -6.67, 95% CI: -15.15, 1.82, p = 0.12), and at the end of follow-up (MD: -7.14, 95% CI: -19.78, 5.50, p = 0.27). Additionally, the results revealed comparable efficacy of PDT and topical antifungal therapy on the clinical outcomes. Conclusions PDT might be considered a viable option for DS either as an adjunct or as an alternative to the topical antifungal medications. Further studies with adequate sample sizes and standardized PDT parameters are warranted.

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Therapeutic efficacy of adjunctive photodynamic therapy in the treatment of denture stomatitis

Cited by 5 publications

References 51 publications

Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: An updated systematic review and meta-analysis

Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: An updated systematic review and meta-analysis

Efficacy of adjunct photodynamic therapy on Candida growth and oral health quality of life in denture stomatitis patients with type 2 diabetes mellitus wearing implant-retained overdentures: A randomized clinical study

Efficacy of photodynamic therapy on candida colonization and clinical symptoms in denture stomatitis: a systematic review and meta-analysis

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