Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study

Abstract

Background. Great plantain (Plantago major L. or P.major) is a medicinal plant that is available all around the world. The whole plant has several bioactive compounds including terpenoids, flavonoids, phenolic compounds, alkaloids, fatty acids, iridoid glycosides, polysaccharides, and vitamins. Scientific studies have recognized several medical benefits like wound healing, anti-inflammatory, antimicrobial, antiulcerative, and antioxidative agents. The wound-healing capacity of this plant has been investigated under in vivo and ex vivo conditions. In the current study, we aim to compare the therapeutic effect of the P.major extract with 1% sulfadiazine on the healing of second-degree burn wounds. Method. Second-degree burn victims were included in our study. The investigation and control group, respectively, received P. major ointment 10% and silver sulfadiazine ointment 1%. The bacterial culture from the wound site was taken on days 3, 7, 10, 13, and last day of hospitalization. Patients’ subjective complaints were obtained through the visual analog scale (VAS). All patients were treated and evaluated in the hospital. Result. Among the 15 patients, 11 were male, and the mean age was 33.3 years. The average complete healing duration was 11.73 vs. 13 days in the P. major and control group, respectively ( P = 0.166 ). On the third day, infection control was similar between the two groups, and on the seventh day, all bacterial cultures were negative. Although there was a significant reduction in pain scores during the recovery time, no significant differences in pain reduction were noted between the two groups ( P = 0.849 ). Conclusion. We showed that P.major ointment is a safe and suitable herbal compound in the treatment of second-degree burn wounds that not only has wound-healing properties but also is an analgesic and antimicrobial compound.

Functional Electrospun Nanofibers Loaded with Plantago Major L. Extract for Potential Use in Cutaneous Wound Healing

“…The wound-healing capacity of the leaf extract has been proved by "in vivo" tests with animals and humans, using different pharmacology forms, such as ointment [30] and topical gel [31].…”

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21st century: A systematic review

“…The average complete healing time in the P. major and control groups was 11.73 d and 13 d, respectively. The study discovered that P. major ointment is a safe and efficient herbal product for the treatment of second-degree burn wounds since it not only cures the lesion but also serves as an analgesic and antibacterial agent[ 138 ]. Ghanadian et al [ 125 ] conducted a clinical study where patients with DFU or pressure ulcers were randomly assigned to medication ( P. major ) or control groups.…”

The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants

“…Plantago major contains a number of active substances, including caffeic acid derivatives, polysaccharides, terpenoids, lipids, and flavonoids, as is shown in Table 3 [ 82 ]. A safe and effective herbal remedy for the treatment of second-degree burn wounds is P. major ointment, which not only contains qualities for healing wounds but also functions as an analgesic and an antibacterial agent [ 83 ]. Furthermore, it was found that, when compared to alternative therapies, P. major extract effectively accelerated the healing of dorsal cervical injuries in mice [ 84 ].…”