2022
DOI: 10.1111/and.14508
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Therapeutic efficacy ofN‐acetylcysteine and zinc sulphate against di‐(2‐ethylhexyl) phthalate‐induced testicular oxido‐nitrergic stress in male Wistar rat

Abstract: The therapeutic efficacy of N-acetylcysteine (NAC) and zinc sulphate on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular oxido-nitrergic stress in rats was investigated in 36 male Wistar rats (170 ± 10 g) randomly assigned into one of six groups (n = 6).Group 1 (control) received 2.5 ml/kg of distilled water for 42 days, while group 2 (vehicle) received 2.5 ml/kg of corn oil for 42 days. Groups 3,4,5, and 6 were administered DEHP (750 mg/kg/day) for 21 days, after which groups 4, 5, and 6 received zinc su… Show more

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Cited by 7 publications
(5 citation statements)
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“…This proves that Zn has significant antioxidant potential [ 80 ]. Also, a study by Emojevwe et al [ 81 ] showed that the administration of Zn ions to rats increased the activity of antioxidant enzymes while reducing ROS and oxidative stress [ 81 ]. Therefore, a new approach in the pharmacotherapy of depressive disorders may be the use of antidepressants enriched in Zn compounds.…”
Section: Discussionmentioning
confidence: 99%
“…This proves that Zn has significant antioxidant potential [ 80 ]. Also, a study by Emojevwe et al [ 81 ] showed that the administration of Zn ions to rats increased the activity of antioxidant enzymes while reducing ROS and oxidative stress [ 81 ]. Therefore, a new approach in the pharmacotherapy of depressive disorders may be the use of antidepressants enriched in Zn compounds.…”
Section: Discussionmentioning
confidence: 99%
“…Histological and morphometric studies: Testicular tissues were kept in 10% buffered formalin for microscopic examination, dried in ethanol alcohols of increasing strength, washed in xylene, cast, embedded, microtomed at 5 m thickness, and stained with hematoxylineosin prior to microscopic examination based on previous protocol [34].…”
Section: Histopathological Examination Of Testesmentioning
confidence: 99%
“…Animal studies showed that zinc (25 mg/kg/d) could restore chlorpyrifos induced reproductive injury in male rats 24 . 0.5 mg/kg/d zinc sulphate combined 100 mg/kg/d N‐acetylcysteine could inhibit DEHP (750 mg/kg/d, 3 weeks) induced testicular oxidative damage in rats 25 . Wang et al 26 reported that 200 mg/kg/d vitamin E could inhibit 500 mg/kg/d DEHP gestational exposure induced testicular toxicity in the offspring rats.…”
Section: Introductionmentioning
confidence: 99%
“…24 0.5 mg/kg/d zinc sulphate combined 100 mg/kg/d N-acetylcysteine could inhibit DEHP (750 mg/kg/d, 3 weeks) induced testicular oxidative damage in rats. 25 Wang et al 26 reported that 200 mg/kg/d vitamin E could inhibit 500 mg/kg/d DEHP gestational exposure induced testicular toxicity in the offspring rats. 50 mg/kg/d zinc sulphate combined 15 mg/kg/d vitamin E could alleviate male reproductive injuries caused by 50 mg/kg/d aluminum sulphate in rats.…”
mentioning
confidence: 99%