Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Chandramohan, Yamini; Parameswari, C. S.

doi:10.1016/s1734-1140(13)71492-0

Cited by 17 publications

(11 citation statements)

References 57 publications

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“…Lin et al [36], add that naringenin upregulates hemeoxygenase enzyme expression in renal tissues maintaining its level and then it reduces renal oxidative stress damage and its oxidative parameters such as malondialdehyde "MDA" and nitric oxide. Chandramohan and Parameswari [26], are also in consistent with our results for an improvement in renal histopathological and ultra-structural changes, cyclosporine blood level, renal functions and redox status parameters due to concurrent use of naringenin and cyclosporine.…”

Section: Discussionsupporting

confidence: 92%

“…There was a significant gain in the rats' body and kidney weight of third group which received naringenin with cyclosporine because of antioxidant effect of naringenin that counteracts effects of cyclosporine induced oxidative stress such as the weight loss in consistent with a previous study [26], but this is in contrast with a study [27] who reported that naringenin reduces the body weight gain based on its insulin-like properties that correct many metabolic disturbances linked to the insulin resistance without any effect on the appetite. There was also a significant gain in the rats' body weight of fourth group, which received an olive oil with cyclosporine in comparison with the second group, which received cyclosporine only, and the third group, which received naringenin with cyclosporine in consistent with [28] who reported that long-term ingestion of virgin olive oil produces weight gain and insulin resistance.…”

Section: Discussionsupporting

confidence: 90%

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Renoprotective Effects of Naringenin and Olive Oil against Cyclosporine- Induced Nephrotoxicity in Rats

Elshama

Osman

El-Kenawy

2016

IJT

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Background: Prolonged use of cyclosporine A for prevention of allograft rejection is associated with nephrotoxicity development. Naringenin and olive oil are beneficial dietary antioxidants with potential renoprotective properties. This study aimed to evaluate the therapeutic effect of naringenin and olive oil in alleviating cyclosporine induced nephrotoxicity in rats by the assessment of renal function and lesions, and redox status parameters. Methods: Eighty adult male rats were divided into four groups during a 45 days treatment period; control group received saline; the second group treated with 25 mg/kg/d of cyclosporine while the third and fourth groups received 100 mg/kg/d of naringenin and 1.25 ml/kg/d of virgin olive oil respectively, together with the same cyclosporine dose. Results: Cyclosporine-treated rats presented renal dysfunction and damage, as viewed by the elevated serum markers of renal function and kidney histopathological lesions, when compared to the control animals with an increase in the blood cyclosporine level and impaired redox status parameters. Conclusion: Co-administration of naringenin or virgin olive oil with cyclosporine alleviated nephrotoxicity by serum urea and creatinine levels reduction, renal lesions amelioration, as well as the improved antioxidant parameters. Naringenin and virgin olive oil have potential to act as natural renoprotective agents against cyclosporine-induced nephrotoxicity.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Renoprotective Effects of Naringenin and Olive Oil against Cyclosporine- Induced Nephrotoxicity in Rats

Elshama

Osman

El-Kenawy

2016

IJT

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“…However, side effects associated with CsA treatment are numerous and kidney dysfunction is the main complication of CsA treatment. 30 This study demonstrated that allicin administration attenuated renal damage in rats treated with CsA. The protective effects of allicin may be multifactorial involving regulatory effects on inflammation and oxidative stress.…”

Section: Discussionmentioning

confidence: 68%

Allicin ameliorates kidney function and urinary bladder sensitivity in cyclosporine A-treated rats

et al. 2016

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Cyclosporine-A (CsA) is an immunosuppressive drug which has been used to prevent rejection after organ transplantation and to treat certain autoimmune diseases. However, its therapeutic use is limited by nephrotoxicity. In this study, the modulator effect of allicin on the oxidative nephrotoxicity of CsA in rats was investigated. Furthermore, the effect of allicin on CsA-induced hypersensitivity of urinary bladder rings to acetylcholine (ACh) was estimated. Rats were divided into three groups, control, CsA (15 mg/kg, subcutaneously), and CsA/allicin (50 mg/kg, orally). At the end of the study, all rats were killed and then blood, urine samples, and kidneys were taken. CsA administration caused a severe nephrotoxicity which was evidenced by elevated kidney/body weight ratio, serum creatinine (Cr), blood urea nitrogen, lactate dehydrogenase, and urinary protein with a concomitant reduction in serum albumin and Cr clearance as compared with control. A significant increase in renal contents of malondialdehyde, myeloperoxidase, and tumor necrosis factor-alpha with a significant decrease in renal reduced glutathione, superoxide dismutase activities, and nitric oxide (NOx) content was detected upon CsA administration. Exposure to CsA increased the sensitivity of isolated urinary bladder rings to ACh. Histological analysis revealed that CsA caused tubular necrosis and moderate diffuse tubular atrophy. Allicin protected kidney tissue against the oxidative damage and the nephrotoxic effect of CsA and significantly reduced the responses of isolated bladder rings to ACh. Our study indicates that allicin administration has the potential to protect against CsA-induced renal injury by reducing oxidative stress and inflammation and restoring NOx level.

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“…The therapeutic effect of EPO‐BMSCs is higher than that of EPO and BMSCs. The rat model of CsA‐induced nephrotoxicity is a well‐defined and highly reproducible model . In vivo, however, EPO‐BMSCs showed higher ability to improve renal function than BMSCs; the CsA‐induced rats treated with EPO‐BMSCs exhibited fewer interstitial lymphocyte infiltrates, less tubular swelling, less necrosis and atrophy, and lower levels of interstitial fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…1 Acute or chronic CsA-induced nephrotoxicity leads to renal function impairment and histopathological and ultrastructural damages. [2][3][4][5] In recent years, several studies have reported that mesenchymal stem cell (MSC) transplantation can prevent or attenuate drug-induced renal injury, [6][7][8] but their effect in CsA-induced nephrotoxicity is not clear.…”

Section: Introductionmentioning

confidence: 99%

Bone mesenchymal stem cells pretreated with erythropoietin enhance the effect to ameliorate cyclosporine A‐induced nephrotoxicity in rats

Zhou

Liu

Zhang

et al. 2018

J of Cellular Biochemistry

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An increasing number of experiments and clinical trials have demonstrated the safety, feasibility, and efficacy of mesenchymal stem cells (MSCs)-based therapies for the treatment of various diseases. The main drawbacks of MSC therapy are the lack of specific homing after systemic infusion and early death of injected cells because of the injury micro-environment. We pretreated bone mesenchymal stem cells (BMSCs) with erythropoietin (EPO) to investigate their positive effect on cyclosporine A (CsA)-induced nephrotoxicity. BMSCs were incubated with different concentrations of EPO (10, 100, 500, and 1000 IU/mL) for 24 and 48 h, and their proliferation rate, cytoskeletal morphology, migration ability, and the expression of CXCR4 were evaluated to determine the optimal pretreatment conditions. To investigate the therapeutic effects of BMSCs pretreated with EPO in CsA-induced nephrotoxicity, we established CsA-induced in vitro and in vivo toxicity models. In our in vitro study, preconditioning of BMSCs with 500 IU/mL EPO for 48 h induced a marked increase in their proliferation rate, cytoskeletal rearrangement, migration in the scrape-healing assay, and migration toward injured HK2 cells. In vivo, EPO-BMSCs showed higher ability to improve renal function than BMSCs, and in CsA-induced rats treated with EPO-BMSCs, interstitial lymphocyte infiltration, tubular swelling, necrosis, and interstitial fibrosis decreased. We demonstrated that pretreatment with 500 IU/mL EPO before infusion markedly increased the homing ability of BMSCs, and obviously ameliorate CsA-induced nephrotoxicity in rats.

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Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: Involvement of hemeoxygenase-1

Cited by 17 publications

References 57 publications

Renoprotective Effects of Naringenin and Olive Oil against Cyclosporine- Induced Nephrotoxicity in Rats

Renoprotective Effects of Naringenin and Olive Oil against Cyclosporine- Induced Nephrotoxicity in Rats

Allicin ameliorates kidney function and urinary bladder sensitivity in cyclosporine A-treated rats

Bone mesenchymal stem cells pretreated with erythropoietin enhance the effect to ameliorate cyclosporine A‐induced nephrotoxicity in rats

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