Therapeutic efficiency of IL-2 gene transduced tumor vaccine for head and neck carcinoma

Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum

“…phokine activated killer (LAK) cells and macrophages, all of which can participate in immunological antitumor mechanisms [17]. IL-2 mRNA level was found to be augmented in LBP 3p -treated S180 murine spleen in the present study, which implied that IL-2 may be involved in the early phase of immune response and induces CTL production.…”

HSV as a vector in vaccine development and gene therapy

“…176,177 HSV amplicon vectors have also been evaluated as cancer vaccines by expressing combinations of cytokines and immunomodulatory proteins for treatment of a variety of experimental tumors. 24,175,[178][179][180][181] A promising, new approach to cancer is the selective degradation of mRNA by RNA interference (RNAi) 182 or interference with microRNAs that support tumor growth. 183 HSV amplicon vectors expressing siRNAs have been used recently to mediate posttranscriptional silencing of EGFR, which is frequently activated in human…”

Construction of the plasmid coding for the expression of the EGFP-M-IL-2(88Arg, 125Ala) fusion protein and the anti-tumor effects exerted by the fusion protein in HeLa-60 cells

“…IL-2 is able to influence several types of cancer effectively, including renal cell carcinoma, melanoma and liver cancer (7)(8)(9). In addition, recombination of the IL-2 gene has been clinically used as a type of drug to treat a variety of tumors (10,11).…”

“…In addition, recombination of the IL-2 gene has been clinically used as a type of drug to treat a variety of tumors (10,11). Despite the functions of IL-2, the toxicity and short half-life of IL-2 also limit the clinical application of this protein (7). Therefore, numerous studies worldwide have investigated mutant recombinant hIL-2 to increase the biological activity of the protein and to minimize the corresponding systemic toxicity (12)(13)(14).…”